Bio-Structural Model of the Human Eye

Arciniegas, Alejandro; Amaya, Luis Enrique

doi:10.1159/000308975

Cited by 16 publications

(12 citation statements)

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“…This analog is quite in accordance with the bio-structural model proposed by the authors [5]; and introducing the numeri cal values of the different spring-constants and hydraulic pressures in Schlemm's canal and in the venous system it could be used in conjunction with the bio-structural model to have an integral model of the myopic eye. But besides reinforcing the mechanical ap proach to the myopic phenomenon, this an alog can be employed to relate and study other phenomena as well, for instance a failure in the drainage system (pre-trabecular glaucoma) or over-pressure in the venous system of the eye (post-trabecular glauco ma).…”

Section: Remarks On the Modelsupporting

confidence: 73%

“…As part of an integral system approach [1,2,6], the authors proposed a structural me chanics model of behavior that correlates more clinical observations than the optical approach [3,5], In order to gain a better insight of the force interplay, the structural model of deformation can be complemented by an analog model in order to study this force interplay. An analog model is one through which a desidered effect is studied by means of a different one that has similar governing equations.…”

Section: Introductionmentioning

confidence: 99%

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Mechanical Analog for the Study of the Internal Forces of the Eye

Arciniegas¹,

Amaya²

1980

Ophthalmologica

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As part of the bio-engineering approach to study myopia and also as a complement to the bio-structural model of the eye presented by the authors, an analog for the study of internal forces is analyzed. The behavior of the model indicates not only that the forces involved in the development of progressive myopia, but those of pre- and post-trabecular glaucomas could be studied and related with such an analog model, supporting the author’s feelings that many medical problems could be successfully explained by engineering methods and techniques.

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Section: Remarks On the Modelsupporting

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Mechanical Analog for the Study of the Internal Forces of the Eye

Arciniegas¹,

Amaya²

1980

Ophthalmologica

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“…There is evidence that it regulates eye growth and shape during development. [3][4][5] It serves as a barrier to the cellular invasion/ migration and the diffusion of large macromolecules, this may help to maintain transparency within the vitreous cavity. 6,7 Vitreous gel, as compared to liquefied vitreous, lowers oxygen tensions in the retina and lens, and the increase in lens oxygenation following vitrectomy predisposes to cataract formation.…”

Section: Introductionmentioning

confidence: 99%

Adult vitreous structure and postnatal changes

Goff

Bishop

2008

Eye

285

206

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This review will focus on the molecular organisation of the adult vitreous and how it undergoes ageing changes throughout life that result in vitreous liquefaction and a predisposition towards posterior vitreous detachment and retinal break formation. At birth, the vitreous humour is in a gel state due to the presence of a network of fine collagen fibrils. With ageing, these collagen fibrils progressively aggregate due to a loss of type IX collagen from their surfaces. The aggregation of collagen fibrils may cause vitreous liquefaction which, when combined with an age-related weakening of postbasal vitreoretinal adhesion, predisposes to posterior vitreous detachment. Throughout postnatal life, the posterior border of the vitreous base migrates posteriorly from the ora serrata into the peripheral retina. This is due to new collagen synthesis by the peripheral retina. This new collagen intertwines with pre-existing cortical vitreous collagen to create new adhesions and thereby extends the vitreous base posteriorly. If irregularities in the posterior border of the vitreous base arise from this process, there is a predisposition towards retinal break formation during posterior vitreous detachment and subsequent rhegmatogenous retinal detachment.

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“…In addi tion. the role played by any load or strain, represented by intraocular pressure, in the production o f a permanent deformation [4][5][6][7][8][9] can also be established.…”

Section: Introductionmentioning

confidence: 99%

Mechanical Behavior of the Sclera

Arciniegas

Amaya

1986

Ophthalmologica

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Induced deformations, similar to the posterior pole deformations due to advanced myopia, were studied in a series of 30 rabbits. The induced deformations were produced by means of a specially designed cup. An analysis of the applicability of the shell theory is made, and it is concluded that the thin shell theory is applicable to the mechanical study of the eyes. The basic experiment consisted of introducing a controlled deformation at different pressure levels; a wide range of types of increments and times of substained deformations were studied. It is concluded that the scleral tissue is an elastic material and has a fairly high ‘Creep’ rate. The material properties indicate that the eye can reaccommodate induced pressure, and thus glaucoma and myopia could be present without external indications of ‘high pressure’ in the eye.

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Bio-Structural Model of the Human Eye

Cited by 16 publications

References 1 publication

Mechanical Analog for the Study of the Internal Forces of the Eye

Mechanical Analog for the Study of the Internal Forces of the Eye

Adult vitreous structure and postnatal changes

Mechanical Behavior of the Sclera

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