Bio-Relevant Derivatives of Calixarene Phosphonic Acids

Cherenok, S. O.; Vovk, А. I.; Muravyova, Iryna; Marcinowicz, Agnieszka; Poznański, J.; Muzychka, Oxana V.; Kukhar, V. P.; Zielenkiewicz, W.; Kаlchеnkо, Vitaly I.

doi:10.1080/10426500701795126

Cited by 5 publications

(1 citation statement)

References 4 publications

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“…This is clearly shown by the number of articles and reviews in the field; three by ourselves on the biopharmaceutical aspects of the calix[n]arenes in 2004, 8 a second on the biochemistry of the p-sulfonato-calix[n]arenes in 2006, 9 and more on calix[n]arenes as protein sensors in 2007. 10 Other major reviews have come from Ludwig, 11 Kalchenko et al in 2009, 12 and a review by Danylyuk and Suwinska on the solid state complexes of the calix[n]arenes with biologically relevant molecules in 2009. 5 In the last few years two schools of thought on the use of calix [n]arenes in biology and medicine are emerging; the first developed by Lin and Hamilton, 13 Brewster et al 14 and Neri et al 15 uses the calix[n]arenes as skeletons onto which various pharmacophores are coupled and the second developed by ourselves, 16 Kalchenko, 17 Schrader et al, 18 Matthews et al, 19 Casnati et al, 20 Shahgaldian et al 21 and others, who have used simple derivatives of the calix[n]arenes as biologically active molecules in their own right.…”

Section: Introductionmentioning

confidence: 99%

Biochemistry of anionic calix[n]arenes

2011

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This review treats the biological properties of the various anionic calix[n]arenes, both as soluble forms and in the colloidal state. The complexation of these molecules with amino-acids, peptides and proteins is discussed, as is their interaction with model membranes. The complexations with various Active Pharmaceutical Ingredients as complexes, for tamoxifen as solid state and colloidal structures, are treated in depth. Two sections deal with the direct biological action of the calix[n]arenes and their use as biosensors. A final section deals with the toxicity, in reality the lack of toxicity of the calix[n]arenes.

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Section: Introductionmentioning

confidence: 99%

Biochemistry of anionic calix[n]arenes

2011

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Asymmetric Synthesis of Quaternary α‐Amino Acids and Their Phosphonate Analogues

2014

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Asymmetric synthesis of α‐amino acids and their phosphonate analogues has received considerable attention due to their diverse biological activities. Quaternary α‐amino acids and their phosphonate analogues are often more resistant to chemical and enzymatic degradation and therefore have been targets of various synthetic endeavors. This Focus Review provides a summary of recent approaches to catalytic asymmetric synthesis of quaternary α‐amino acids and α‐aminophosphonates.

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Biomedizinische Anwendungen von Calixarenen: Stand der Wissenschaft und Perspektiven

Pan

Guo

2020

Angewandte Chemie

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Calixarene (CAs) stellen die dritte Generation supramolekularer Wirtsstrukturen dar und sind eine der am häufigsten untersuchten makrocyclischen Gerüststrukturen. Sie bieten aufgrund ihrer einfachen Modifikation (fast) unbegrenzte Möglichkeiten, um große Molekülbibliotheken als Materialbasis für vielfältige biomedizinische Anwendungen zu etablieren. Darüber hinaus beteiligen sich CAs und ihre Derivate an verschiedenen nichtkovalenten Interaktionen zur einfachen Erkennung von Gaststrukturen, einschließlich bioaktiver Moleküle, und sind auch wichtige Bausteine für die Herstellung supramolekularer Architekturen. Im Hinblick auf ihre molekularen Erkennungs‐ und Selbstorganisationseigenschaften werden CAs in großem Umfang in der Biosensorik, dem Bioimaging und im Wirkstoff‐/Gentransport eingesetzt. Weiterhin weisen einige CA‐Derivate biologische Aktivitäten auf und können daher als neue Therapeutika eingesetzt werden. Wir fassen hier die vielfältigen biomedizinischen Anwendungen von CAs zusammen, einschließlich der In‐vitro‐Diagnostik (Biosensorik), In‐vivo‐Diagnostik (Bioimaging) und Therapie.

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Bio-Relevant Derivatives of Calixarene Phosphonic Acids

Cited by 5 publications

References 4 publications

Biochemistry of anionic calix[n]arenes

Biochemistry of anionic calix[n]arenes

Asymmetric Synthesis of Quaternary α‐Amino Acids and Their Phosphonate Analogues

Biomedizinische Anwendungen von Calixarenen: Stand der Wissenschaft und Perspektiven

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