Bio-functionalization of microfluidic platforms made of thermoplastic materials: A review

Shakeri, Amid; Jarad, Noor Abu; Khan, Shadman; Didar, Tohid F.

doi:10.1016/j.aca.2021.339283

Cited by 47 publications

(38 citation statements)

References 138 publications

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“…Thus, in this review, COC is the main focus and COP will be stated clearly when used. The majority of existing reviews focused mainly on rigid thermoplastics such as PMMA, PS, and PC, [40][41][42][43][44][45][46] and flexible polymers [47] such as parylene, and poly(ethylene terephthalate) for biomedical application. Others reviewed the fabrication aspects of polymer microfluidics, [48,49] and the bonding of various thermoplastics and PDMS.…”

Section: Introductionmentioning

confidence: 99%

A Review of Cyclic Olefin Copolymer Applications in Microfluidics and Microdevices

Agha

Waheed

Alamoodi

et al. 2022

Macro Materials & Eng

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Cyclic olefin copolymers (COC) are amorphous, transparent thermoplastics composed of cyclic olefin monomers (norbornene) and linear olefins (ethene). They are increasingly utilized as fabrication materials for microsystems and microfluidic devices, owing to their promising features of low water absorption, high electrical insulation, long-term stability of surface treatments, and resistance to a broad variety of acids and solvents. Many manufacturing processes for COC-based devices have been developed in recent decades. These methodologies are categorized as replication methods or fast prototyping as common in fabrication of thermoplastic microfluidic devices. This review gives a full discussion of the features of COCs, the various production processes, and the numerous selected applications in microfluidic platforms. The review also explores COC's composition and fundamental features, as well as fabrication processes and applications in a variety of fields, investigates the material's potential advantages and uses, and attempts to create a comprehensive list of COC's possible benefits. Due to their unique features and simplicity of fabrication, COCs are projected to advance the future of microfluidics, microsystems, and optofluidics.

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Section: Introductionmentioning

confidence: 99%

A Review of Cyclic Olefin Copolymer Applications in Microfluidics and Microdevices

Agha

Waheed

Alamoodi

et al. 2022

Macro Materials & Eng

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“…Polystyrene (PS) is a highly stable and non-polar linear polymer that contains benzene as a pendant group ( Bhavsar et al, 2018 ; Shakeri et al, 2022a ). Its exceptional properties, including high mechanical and thermal stability, chemical resistance, biocompatibility, and optical transparency, make it an attractive material for microfluidic device fabrication ( de Oliveira et al, 2021 ; Zhou et al, 2021 ).…”

Section: Methodsmentioning

confidence: 99%

“…PMMA is also biocompatible and can be sterilized easily by various sterilization methods, such as autoclaving ( Guzzi et al, 2020 ; Khot et al, 2020 ) and chemical sterilization ( Nguyen et al, 2019 ; Ameri et al, 2022 ), making it useful for biotechnological and biomedical applications. However, PMMA has some limitations, including high hydrophobicity and low mechanical strength ( Amirabad et al, 2022 ; Shakeri et al, 2022a ; Kulkarni & Goel, 2022 ).…”

Section: Methodsmentioning

confidence: 99%

Breaking the clean room barrier: exploring low-cost alternatives for microfluidic devices

Rodríguez

Andrade-Pérez

Vargas

et al. 2023

Front. Bioeng. Biotechnol.

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Microfluidics is an interdisciplinary field that encompasses both science and engineering, which aims to design and fabricate devices capable of manipulating extremely low volumes of fluids on a microscale level. The central objective of microfluidics is to provide high precision and accuracy while using minimal reagents and equipment. The benefits of this approach include greater control over experimental conditions, faster analysis, and improved experimental reproducibility. Microfluidic devices, also known as labs-on-a-chip (LOCs), have emerged as potential instruments for optimizing operations and decreasing costs in various of industries, including pharmaceutical, medical, food, and cosmetics. However, the high price of conventional prototypes for LOCs devices, generated in clean room facilities, has increased the demand for inexpensive alternatives. Polymers, paper, and hydrogels are some of the materials that can be utilized to create the inexpensive microfluidic devices covered in this article. In addition, we highlighted different manufacturing techniques, such as soft lithography, laser plotting, and 3D printing, that are suitable for creating LOCs. The selection of materials and fabrication techniques will depend on the specific requirements and applications of each individual LOC. This article aims to provide a comprehensive overview of the numerous alternatives for the development of low-cost LOCs to service industries such as pharmaceuticals, chemicals, food, and biomedicine.

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“…• Soft stimuli-responsive polymer actuators for controlling flow direction and flow rate (Figure 1C) (Delaney et al, 2017;Saez et al, 2018). • Functionalised channels walls endowed with sensing capabilities for monitoring changes in pH, metal ion concentrations, solvent polarity, and biochemistry (Figure 1D) (Florea et al, 2012(Florea et al, , 2013a(Florea et al, , 2013bLuka et al, 2015;Shakeri et al, 2022;Dunne et al, 2018). • Surface tension/interfacial tension modulation for flow (regime) control and fluid mixing (Diguet et al, 2011;Venancio-Marques et al, 2013).…”

Section: Strategies For Extending Biochemical Sensor Lifetimementioning

confidence: 99%

Sensors and “The internet of biochemical things”

Florea

Diamond²

2022

Front. Sens.

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In this perspective article, we consider the pathway biochemical sensing will take as the huge businesses underpinning Big Data and the Internet of Things seek new layers of highly valuable information to integrate into our increasingly digitised world. Up to now, the complexity of biochemical sensing has limited its inclusion in a manner similar to more reliable and lower cost technologies based on physical transducers. At its core, this complexity arises from the fundamental need for biochemical sensors to interact intimately at the molecular level with one or more specific components (analytes) in samples that are often highly complex and hostile to the sensors. This limits the functional lifetime of biochemical sensors to at best days or weeks or most commonly single use, making long-term embedded use-models developed for Internet of Things applications beyond reach. Nevertheless, even single use sensors can lead to “big data”, if used in large enough scale (e.g., COVID-19 diagnostics), and progress in continuous is beginning to make headway towards longer-term use models in health and environmental monitoring. New concepts exploiting advanced materials and biomimetic concepts offer opportunities to further extend the lifetime of biochemical sensing devices.

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Bio-functionalization of microfluidic platforms made of thermoplastic materials: A review

Cited by 47 publications

References 138 publications

A Review of Cyclic Olefin Copolymer Applications in Microfluidics and Microdevices

A Review of Cyclic Olefin Copolymer Applications in Microfluidics and Microdevices

Breaking the clean room barrier: exploring low-cost alternatives for microfluidic devices

Sensors and “The internet of biochemical things”

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