Bio-active glass coatings manufactured by thermal spray: a status report

Henao, John; Poblano-Salas, C. A.; Monsalve, Mauricio; Corona‐Castuera, Jorge; Barceinas-Sanchez, O.

doi:10.1016/j.jmrt.2019.07.011

Cited by 53 publications

(39 citation statements)

References 129 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Due to the favourable combinations of properties, BGMS10 seems to be an optimal candidate for the production of sintered products for clinical trials, such as sintered disks, scaffolds and coatings [ 33 , 34 ]. Before starting with costly in vivo experiments, in the present paper such bioactive glass is tested by means of in vitro test with human dental pulp stem cells (hDPSCs) as a further investigation.…”

Section: Introductionmentioning

confidence: 99%

Effects of a Novel Bioactive Glass Composition on Biological Properties of Human Dental Pulp Stem Cells

et al. 2020

View full text Add to dashboard Cite

Functional reconstruction of bone defects represents a clinical challenge in the regenerative medicine field, which targets tissue repair following traumatic injuries and disease-related bone deficiencies. In this regard, the optimal biomaterial should be safe, biocompatible and tailored in order to promote the activation of host progenitor cells towards bone repair. Bioactive glasses might be suitable biomaterials due to their composition being able to induce the host healing response and, eventually, anti-bacterial properties. In this study we investigated whether and how an innovative bioactive glass composition, called BGMS10, may affect cell adhesion, morphology, proliferation, immunomodulation and osteogenic differentiation of human dental pulp stem cells (hDPSCs). When cultured on BGMS10, hDPSCs maintained their proliferation rate and typical fibroblast-like morphology, showing the expression of stemness markers STRO-1 and c-Kit. Moreover, the expression of FasL, a key molecule in mediating immunomodulation effects of hDPSCs, was maintained. BGMS10 also proved to trigger osteogenic commitment of hDPSCs, as confirmed by the activation of bone-related transcription factors RUNX2 and Osx and the ongoing deposition of extracellular matrix supported by the expression of OPN and OCN. Our findings suggest that BGMS10 not only maintains the typical biological and immunomodulatory properties of hDPSCs but also favors the osteogenic commitment.

show abstract

Section: Introductionmentioning

confidence: 99%

Effects of a Novel Bioactive Glass Composition on Biological Properties of Human Dental Pulp Stem Cells

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Typically, such applications require thermal treatments to obtain products, such as sintered parts, scaffolds and coatings [ 11 , 12 ]. In this scenario, the crystallization behavior is of pivotal importance, since it is well known that crystallization can inhibit, or at least reduce, bioactivity [ 2 ] and, in some cases, even undermine the stability of the implant [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

A Novel Bioactive Glass Containing Therapeutic Ions with Enhanced Biocompatibility

et al. 2020

View full text Add to dashboard Cite

A novel bioactive glass containing therapeutic ions with enhanced biocompatibility was designed and produced by the classical melt-quenching route. Starting from a very promising composition (Bio_MS), which combined bioactivity and high crystallization temperature, the ratio between some oxides was tailored to obtain a new and more reactive (in terms of dissolution rate) bioactive glass, called BGMSN (composition in mol%: 6.1 Na2O, 31.3 CaO, 5 MgO, 10 SrO, 2.6 P2O5, 45 SiO2). The aim of this work was to produce a bioactive glass with a good biological performance, preserving, at the same time, the high crystallization temperature achieved for Bio_MS; this is strategic in order to avoid undesired crystalline phases during thermal treatments, which can undermine the bioactivity and even the stability of final products. A complete characterization of the novel bioactive glass was performed in terms of thermal, mechanical and biological properties and in vitro bioactivity. The thermal behavior of the bioactive glass was studied by heating microscopy, differential thermal analysis (DTA) and optical dilatometry; BGMSN showed a very high crystallization temperature and a high sinterability parameter, thus being suitable for applications where thermal treatments are required, such as sintered samples, coatings and scaffolds. Mechanical properties were investigated by the micro-indentation technique. The in vitro biological properties were evaluated by means of both direct and indirect cell tests, i.e., neutral red (NR) uptake and MTT assay, using murine long bone osteocyte Y4 (MLO-Y4) cells: the cellular viability of BGMSN was higher compared to cellular viability of 45S5, both in direct and indirect tests. Finally, the in vitro bioactivity test by soaking samples in simulated body fluid (SBF) showed high dissolution rate, with a good rate of formation of hydroxyapatite.

show abstract

“…It should be stressed that FGC is obtained by using bioactive hydroxyapatite (HA) doped by Ag, Zn, ZrO 2 , TiO 2 . Another group of graded coatings uses bioinert Ti alloy sprayed with Al, V, Nb, Zr and with bioactive bioglasses [272,273].…”

Section: Bioactivity and Simulated Body Fluid Corrosion Resistancementioning

confidence: 99%

Review of Functionally Graded Thermal Sprayed Coatings

et al. 2020

View full text Add to dashboard Cite

The paper briefly describes major thermal spray techniques used to spray functionally graded coatings such as atmospheric plasma spraying, high velocity oxy-fuel spraying, suspension and solution precursor plasma spraying, and finally low and high pressure cold gas spray method. The examples of combined spray processes as well as some examples of post spray treatment including laser and high temperature treatments or mechanical one, are described. Then, the solid and liquid feedstocks used to spray and their properties are shortly discussed. The reviewed properties of functional coatings include: (i) mechanical (adhesion, toughness, hardness); (ii) physical (porosity, thermal conductivity and diffusivity, thermal expansion, photo-catalytic activity), and; (iii) bioactivity and simulated body fluid (SBF) corrosion. These properties are useful in present applications of functionally graded coatings as thermal barriers, the bioactive coatings in prostheses, photo-catalytic coatings in water treatment, coatings used in printing industry (anilox and corona rolls). Finally, some of the future possible fields of functional thermal sprayed coatings applications are discussed, e.g., to coat polymer substrates or to use the cheap technology of low pressure cold gas spray method instead of expensive technology of vacuum plasma spraying to obtain bond coatings.

show abstract

Bio-active glass coatings manufactured by thermal spray: a status report

Cited by 53 publications

References 129 publications

Effects of a Novel Bioactive Glass Composition on Biological Properties of Human Dental Pulp Stem Cells

Effects of a Novel Bioactive Glass Composition on Biological Properties of Human Dental Pulp Stem Cells

A Novel Bioactive Glass Containing Therapeutic Ions with Enhanced Biocompatibility

Review of Functionally Graded Thermal Sprayed Coatings

Contact Info

Product

Resources

About