2015
DOI: 10.1007/s10616-015-9869-6 View full text |Buy / Rent full text
|
|

Abstract: Many cytological studies have reported that the numbers of binucleated cells were elevated in various tumors. However, binucleated cells are observed in not only malignant tumors but also normal tissues. Thus, the clinical significance of binucleated cells is controversial. Here we attempted to elucidate the characteristics of binucleated HeLa cells using time-lapse microscopy. To examine the frequency, viability, proliferation, and formation mechanism of binucleated cells, we grew HeLa cells on chamber slides… Show more

Help me understand this report

Search citation statements

Order By: Relevance
Select...
1
1
1
0
6
0

Year Published

2016
2016
2022
2022

Publication Types

Select...
4

Relationship

0
4

Authors

Journals

0
6
0
Order By: Relevance
“…This indicated that STK16-IN-1 exerted its effect through STK16 kinase. We then screened a panel of mutations 16 in the STK16 kinase ATP binding pocket including the L98F, L98Q, G104 (N, D, E), and F100C and found that STK16 F100C mutation could significantly abolish STK16-IN-1's inhibitory effect (Supporting Figure 9). Transformation of this mutant into HeLa cells with a GFP-FLAG labeled STK16 kinase showed that the G2/M-phase cell cycle arrest effect of STK16-IN-1 was rescued (Figure 4E,F).…”
Section: Acs Chemical Biologymentioning
Create an account to read the remaining citation statements from this report. You will also get access to:
  • Search over 1.2b+ citation statments to see what is being said about any topic in the research literature
  • Advanced Search to find publications that support or contrast your research
  • Citation reports and visualizations to easily see what publications are saying about each other
  • Browser extension to see Smart Citations wherever you read research
  • Dashboards to evaluate and keep track of groups of publications
  • Alerts to stay on top of citations as they happen
  • Automated reference checks to make sure you are citing reliable research in your manuscripts
  • 7 day free preview of our premium features.

Trusted by researchers and organizations around the world

Over 130,000 students researchers, and industry experts at use scite

See what students are saying

rupbmjkragerfmgwileyiopcupepmcmbcthiemesagefrontiersapsiucrarxivemeralduhksmucshluniversity-of-gavle
“…This indicated that STK16-IN-1 exerted its effect through STK16 kinase. We then screened a panel of mutations 16 in the STK16 kinase ATP binding pocket including the L98F, L98Q, G104 (N, D, E), and F100C and found that STK16 F100C mutation could significantly abolish STK16-IN-1's inhibitory effect (Supporting Figure 9). Transformation of this mutant into HeLa cells with a GFP-FLAG labeled STK16 kinase showed that the G2/M-phase cell cycle arrest effect of STK16-IN-1 was rescued (Figure 4E,F).…”
Section: Acs Chemical Biologymentioning
“…On the other hand, the number of binucleated cells in the progerin group is higher than that of the WT lamin A group, regardless of flow condition or shear level ( Figures 6E–G ). Binucleation appears to be a hallmark of progerin-expressing ECs, and shear-induced binucleation could be a result of cytokinesis failure in progerin-expressing ECs ( Nishimura et al, 2016 ). No significant changes were observed in WT lamin A-expressing cells under different flow conditions, indicating that normal shear stress did not prevent these cells from entering the G2/M phase.…”
Section: Resultsmentioning
“…We also found a higher average frequency of PNCs in participants with obesity, which is indicative of increased cytokinesis failure. Cancer cell lines have been used to demonstrate the mutagenic consequences of binucleated cells [ 96 ]. In a recent review, tetraploidy and cytokinesis failure have been evaluated as mechanisms for aneuploidy in subsequent mitotic cycles.…”
Section: Discussionmentioning