Binswanger's Disease and Normal-pressure Hydrocephalus

Cognitive Profile of Idiopathic Normal Pressure Hydrocephalus

“…This finding is consistent with the cognitive features of subcortical dementia, which arises from disruption of the frontal-subcortical circuits [23,24,25]. Previous neuroimaging studies have reported that frontal cortical grey matter volume is preserved, but frontal regional cerebral blood flow (rCBF) is decreased in iNPH patients [26,27,28,29].…”

Cognitive Profile of Idiopathic Normal Pressure Hydrocephalus

“…This finding is consistent with the cognitive features of subcortical dementia, which arises from disruption of the frontal-subcortical circuits [23,24,25]. Previous neuroimaging studies have reported that frontal cortical grey matter volume is preserved, but frontal regional cerebral blood flow (rCBF) is decreased in iNPH patients [26,27,28,29].…”

Normal-Pressure Hydrocephalus: Is There a Genetic Predisposition?

“…Computed tomogram (CT) scan of the head showed enlargement of the ventricles greater than expected for the degree of atrophy present (Figure 1), which is in agreement with the neuroimaging criteria for diagnosis of NPH 15 . Magnetic resonance imaging showed that the ventricular system was markedly symmetrically dilated, including the fourth and third ventricles.…”

Three decades of normal pressure hydrocephalus: are we wiser now?

“…'7 18 Differential diagnostic problems may still arise in some patients with subcortical arteriosclerotic encephalopathy, whose clinical picture may be similar to that of NPH. 93 The term "Hakim's clinical triad" is misleading because it may suggest that, in patients with this triad, NPH ranks at the top of the differential diagnostic list. In fact, subcortical arteriosclerotic encephalopathy is much more common than NPH and is the most probable cause of the so called "classical" triad.…”

Cognitive Profile of Idiopathic Normal Pressure Hydrocephalus

“…This finding is consistent with the cognitive features of subcortical dementia, which arises from disruption of the frontal-subcortical circuits [23,24,25]. Previous neuroimaging studies have reported that frontal cortical grey matter volume is preserved, but frontal regional cerebral blood flow (rCBF) is decreased in iNPH patients [26,27,28,29].…”

Normal-Pressure Hydrocephalus: Is There a Genetic Predisposition?

“…Computed tomogram (CT) scan of the head showed enlargement of the ventricles greater than expected for the degree of atrophy present (Figure 1), which is in agreement with the neuroimaging criteria for diagnosis of NPH 15 . Magnetic resonance imaging showed that the ventricular system was markedly symmetrically dilated, including the fourth and third ventricles.…”

Three decades of normal pressure hydrocephalus: are we wiser now?

“…'7 18 Differential diagnostic problems may still arise in some patients with subcortical arteriosclerotic encephalopathy, whose clinical picture may be similar to that of NPH. 93 The term "Hakim's clinical triad" is misleading because it may suggest that, in patients with this triad, NPH ranks at the top of the differential diagnostic list. In fact, subcortical arteriosclerotic encephalopathy is much more common than NPH and is the most probable cause of the so called "classical" triad.…”

Cognitive Profile of Idiopathic Normal Pressure Hydrocephalus

“…This finding is consistent with the cognitive features of subcortical dementia, which arises from disruption of the frontal-subcortical circuits [23,24,25]. Previous neuroimaging studies have reported that frontal cortical grey matter volume is preserved, but frontal regional cerebral blood flow (rCBF) is decreased in iNPH patients [26,27,28,29].…”

Normal-Pressure Hydrocephalus: Is There a Genetic Predisposition?

“…Computed tomogram (CT) scan of the head showed enlargement of the ventricles greater than expected for the degree of atrophy present (Figure 1), which is in agreement with the neuroimaging criteria for diagnosis of NPH 15 . Magnetic resonance imaging showed that the ventricular system was markedly symmetrically dilated, including the fourth and third ventricles.…”

Three decades of normal pressure hydrocephalus: are we wiser now?

“…'7 18 Differential diagnostic problems may still arise in some patients with subcortical arteriosclerotic encephalopathy, whose clinical picture may be similar to that of NPH. 93 The term "Hakim's clinical triad" is misleading because it may suggest that, in patients with this triad, NPH ranks at the top of the differential diagnostic list. In fact, subcortical arteriosclerotic encephalopathy is much more common than NPH and is the most probable cause of the so called "classical" triad.…”