Binding of lanthanides to cell membranes in the presence of ligands

Bingham, Derek; Dobrota, Miloslav

doi:10.1016/0162-0134(94)00053-d

Cited by 12 publications

(7 citation statements)

References 24 publications

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“…In addition, little consensus has yet been reached regarding the life cycle of REEs in plant cells. Some studies report that REEs cannot enter the plant cells but only be localized in apoplast (8)(9)(10)(11)(12)(13)(14); other studies, however, argue that REEs cannot only enter the plant cells, but also be deposited inside the cells, such as in the membranes of chloroplast, vacuole, cytoplasm, and nucleus (15)(16)(17)(18)(19)(20)(21). The discrepancy may be because of different experimental methods and different concentrations of REE ions used in separate studies.…”

mentioning

confidence: 84%

Rare earth elements activate endocytosis in plant cells

Wang

Zhou

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

124

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It has long been observed that rare earth elements (REEs) regulate multiple facets of plant growth and development. However, the underlying mechanisms remain largely unclear. Here, using electron microscopic autoradiography, we show the life cycle of a light REE (lanthanum) and a heavy REE (terbium) in horseradish leaf cells. Our data indicate that REEs were first anchored on the plasma membrane in the form of nanoscale particles, and then entered the cells by endocytosis. Consistently, REEs activated endocytosis in plant cells, which may be the cellular basis of REE actions in plants. Moreover, we discovered that a portion of REEs was successively released into the cytoplasm, self-assembled to form nanoscale clusters, and finally deposited in horseradish leaf cells. Taken together, our data reveal the life cycle of REEs and their cellular behaviors in plant cells, which shed light on the cellular mechanisms of REE actions in living organisms.activation | endocytic vesicle S ome trace elements, such as rare earth elements (REEs), have been observed for a long time to be beneficial to plant growth (1, 2). REEs are f-block elements in the periodic table, including 15 lanthanides, plus scandium and yttrium (2). The beneficial effect of REEs on plants was first reported in 1917, when it was found that cerium, an REE, improved physiological activities of water-floss (Spirogyra) (3). Since the 1970s, REEs have been widely used in agriculture as plant growth stimulants (4). Currently, more than 100 of crop species have been applied with REEs, which has increased crop yields by 5-15% (4). In addition, REEs also serve to protect plants against certain plant diseases and some stresses, such as drought, cold, acid rain, or heavy metals (2). The wide use of REEs has caused an overaccumulation of REEs in the ecosystem, including soil (5), atmosphere (6), and water (7). Moreover, it was shown that REEs have dual effects on plant growth: low concentrations of REEs exert positive effects on growth and yield of crops, whereas high concentrations of REEs seem to be harmful for plants, indicating that REEs are not absolutely good for plants (2). Therefore, it is imperative to elucidate how REEs act on plant cells to ensure food safety.Despite of many advances achieved in recent years, the action mechanisms of REEs on plant cells still remain poorly understood (2). Several explanations, which are mainly focused on the physiological roles of REEs in plant cells, have been proposed (2). These mechanisms include the possible changes of photosynthesis, mineral nutrient uptake and metabolism, catalytic activities of some enzymes, hormonal balance, and so forth (2). However, these hypotheses are not connected to any cellular or molecular principles and are therefore far from explaining the action mechanisms of REEs in plants (2,8). In addition, little consensus has yet been reached regarding the life cycle of REEs in plant cells. Some studies report that REEs cannot enter the plant cells but only be localized in apoplast (8-14); other st...

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mentioning

confidence: 84%

Rare earth elements activate endocytosis in plant cells

Wang

Zhou

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

124

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“…Most studies suggest that REE 3+ ions are highly bound to membrane components but poorly internalized [45,46]. However, it is difficult to make a quantitative assessment of intracellular REE 3+ ions because the concentration of the extracellular bound REE generally exceeds that of intracellular REE 3+ ions by several orders of magnitudes.…”

Section: Across Membrane Transport Of Reementioning

confidence: 99%

Isotopic tracer studies of chemical behavior of rare earth elements in environmental and biological sciences

Zhang¹,

Chai²

2004

Radiochimica Acta

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Rare earth elements (REE), a group of elements with atomic numbers from 57 to 71, have been widely applied in recent years not only in industry but also in agriculture, forestry, animal husbandry and medicine. Numerous anthropogenic activities make REE to easily enter the environment and finally the human body via the food chain. Therefore, detailed studies on chemical behavior of these metals in environmental and biological systems are imperative. Isotopic tracer method is especially suited to such studies and has played an important role in assessing the environmental effects of REE. In this paper, some recent progress in the study of chemical behavior of REE in environmental and biological sciences made by the isotopic tracer method is outlined.

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“…For instance, after 3 days of oral uptake from drinking water of LaCl 3 , radiolabeled with 140 La, 6±2 nmol La 3+ g -1 was found in tissue in the heart, 23±8 in liver, 23±2 in kidney and 12±1 in spleen. More work appears necessary to assess uptake and biodistribution upon oral administration of Lanthanum Carbonate [23][24][25].…”

Section: Fourth: No Data Are Available Concerning the Possibility Of mentioning

confidence: 99%

Blast from the Past: The Aluminums Ghost on the Lanthanum Salts

Canavese¹,

Mereu²,

Nordio³

et al. 2005

CMC

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Hyperphosphatemia is a common serious complication of chronic renal diseases, which needs appropriate continuous treatment in order to avoid ominous side effects. Therefore, oral chelating agents able to avoid phosphate absorption by the gut are mandatory. In the past, Aluminium salts, and more recently Calcium and Magnesium salts, and a synthetic resin polyallylamine hydrochloride have been employed, but Aluminium was later abandoned, because it has been a silent killer of many uremic patients, due to subtle absorption eventually leading to toxicity on Central Nervous System and bone, with allucinations, seizures, dementia, and osteomalacia, bone pain, fracturing osteodystrophy, and death. Recently, a new chelating agent able to bind dietary phosphate, namely Lanthanum carbonate has been introduced, with a proven efficacy profile for short-term treatment. However, after careful examination of the very few scientific papers available to date, we strongly advise caution before adopting, at present, lanthanum carbonate as a phosphate binder in uremic patients. In fact, notwithstanding minimized, some data are worrying: first, Lanthanum ions are absorbed, though at a minimal extent, by human gut; 2) pharmacokinetic evaluations show a greater exposure to Lanthanum in uremic patients;3) Lanthanum concentration is increased tenfold in blood and fivefold in bone after short-term supplementation in uremic patients; 4) there is no proofs that Lanthanum cannot cross the blood brain barrier in uremic patients; 5)Lanthanum has many biological effects and is potentially highly toxic. The Aluminum story should serve as cautionary tale when considering the use of new metal ions.

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Binding of lanthanides to cell membranes in the presence of ligands

Cited by 12 publications

References 24 publications

Rare earth elements activate endocytosis in plant cells

Rare earth elements activate endocytosis in plant cells

Isotopic tracer studies of chemical behavior of rare earth elements in environmental and biological sciences

Blast from the Past: The Aluminums Ghost on the Lanthanum Salts

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