2011
DOI: 10.1007/s10847-011-0034-3
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Abstract: Dapsone (DAP) is a synthetic sulfone drug with bacteriostatic activity, mainly against Mycobacterium leprae. In this study we have investigated the interactions of DAP with cyclodextrins, 2-hydroxypropyl-b-cyclodextrin (HPbCD) and b-cyclodextrin (bCD), in the presence and absence of water-soluble polymers, in order to improve its solubility and bioavailability. Solid systems DAP/HPbCD and DAP/bCD, in the presence or absence of polyvinylpyrrolidone (PVP K30) or hydroxypropyl methylcellulose (HPMC), were prepare… Show more

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Cited by 35 publications
(18 citation statements)
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“…The architectural arrangement of Dap / β ‐CD was proposed based on detailed data provided by the 1D ROESY. Such results have already been presented in the preceding texts in different experimental conditions; however, we repeated the experiments paying special attention to the selective 180° pulse used in the 1D ROESY and quantification by integrating the ROE values to obtain a detailed structure of the complex. The signal enhancements revealed dipolar cross relaxations between β ‐CD H3 and Dap Ha and Hb (0.64 and 0.34%, respectively) and between β ‐CD H5 and Dap Ha and Hb (1.79 and 0.90%, respectively).…”
Section: Resultssupporting
confidence: 53%
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“…The architectural arrangement of Dap / β ‐CD was proposed based on detailed data provided by the 1D ROESY. Such results have already been presented in the preceding texts in different experimental conditions; however, we repeated the experiments paying special attention to the selective 180° pulse used in the 1D ROESY and quantification by integrating the ROE values to obtain a detailed structure of the complex. The signal enhancements revealed dipolar cross relaxations between β ‐CD H3 and Dap Ha and Hb (0.64 and 0.34%, respectively) and between β ‐CD H5 and Dap Ha and Hb (1.79 and 0.90%, respectively).…”
Section: Resultssupporting
confidence: 53%
“…The structure of the Dap / β ‐CD complex was sensitive to the NMR experimental parameters. Thus, in our experiments, Dap was fully inserted into β ‐CD, similar to some complexes studied by 1 H NMR but different from others suggested based on emission spectroscopy . However, atomic level interactions are specially observed by NMR spectroscopy, producing more accurate information regarding the architecture of the supramolecular complexes.…”
Section: Resultssupporting
confidence: 40%
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