BIN4, a Novel Component of the Plant DNA Topoisomerase VI Complex, Is Required for Endoreduplication in <i>Arabidopsis</i>

Breuer, Christian; Stacey, Nicola; West, Claudia; Zhao, Yunde; Chory, Joanne; Tsukaya, Hirokazu; Azumi, Yoshitaka; Maxwell, Anthony; Roberts, Keith; Sugimoto‐Shirasu, Keiko

doi:10.1105/tpc.107.054833

Cited by 109 publications

(138 citation statements)

References 43 publications

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“…Phvul.011G213300 is an ortholog of Arabidopsis thaliana BB, a component of the ubiquitin ligase degradation pathway that controls flower and stem size 38 , and Phvul.009G040200 is an ortholog of BIN4, which regulates cell expansion and final plant size 39 . Multiple candidate genes for domestication were also components of nitrogen metabolism pathways, which directly affect plant size.…”

Section: A R T I C L E Smentioning

confidence: 99%

A reference genome for common bean and genome-wide analysis of dual domestications

et al. 2014

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Common bean (Phaseolus vulgaris L.) is the most important grain legume for human consumption and has a role in sustainable agriculture owing to its ability to fix atmospheric nitrogen. We assembled 473 Mb of the 587-Mb genome and genetically anchored 98% of this sequence in 11 chromosome-scale pseudomolecules. We compared the genome for the common bean against the soybean genome to find changes in soybean resulting from polyploidy. Using resequencing of 60 wild individuals and 100 landraces from the genetically differentiated Mesoamerican and Andean gene pools, we confirmed 2 independent domestications from genetic pools that diverged before human colonization. Less than 10% of the 74 Mb of sequence putatively involved in domestication was shared by the two domestication events. We identified a set of genes linked with increased leaf and seed size and combined these results with quantitative trait locus data from Mesoamerican cultivars. Genes affected by domestication may be useful for genomics-enabled crop improvement.

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Section: A R T I C L E Smentioning

confidence: 99%

A reference genome for common bean and genome-wide analysis of dual domestications

et al. 2014

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“…The transgenic lines with CDKB2;1pro:GUS or CYCB1;1-GUS were previously described by Adachi et al (Adachi et al, 2006) and Breuer et al (Breuer et al, 2007). The mp, bdl and van3 mutants were in Lansdberg erecta (Ler) ecotype and axr2-1, HS:axr3-1, pid, yuc1 yuc4 yuc10 yuc11 and ipt3 ipt5 ipt7 mutants were in Columbia (Col) ecotype.…”

Section: Plant Materials and Growth Conditionsmentioning

confidence: 99%

“…Likewise, there are numerous experimental data reported for ploidy-dependent cell expansion (e.g. SugimotoShirasu et al, 2005;Breuer et al, 2007;De Veylder et al, 2002), whereas almost no examples have been found so far for cell expansion-induced endoreduplication.…”

Section: How Does Cell Cycle Transition Link With the Initiation Of Cmentioning

confidence: 99%

Auxin modulates the transition from the mitotic cycle to the endocycle in Arabidopsis

et al. 2010

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SUMMARYAmplification of genomic DNA by endoreduplication often marks the initiation of cell differentiation in animals and plants. The transition from mitotic cycles to endocycles should be developmentally programmed but how this process is regulated remains largely unknown. We show that the plant growth regulator auxin modulates the switch from mitotic cycles to endocycles in Arabidopsis; high levels of TIR1-AUX/IAA-ARF-dependent auxin signalling are required to repress endocycles, thus maintaining cells in mitotic cycles. By contrast, lower levels of TIR1-AUX/IAA-ARF-dependent auxin signalling trigger an exit from mitotic cycles and an entry into endocycles. Our data further demonstrate that this auxin-mediated modulation of the mitotic-to-endocycle switch is tightly coupled with the developmental transition from cell proliferation to cell differentiation in the Arabidopsis root meristem. The transient reduction of auxin signalling by an auxin antagonist PEO-IAA rapidly downregulates the expression of several core cell cycle genes, and we show that overexpressing one of the genes, CYCLIN A2;3 (CYCA2;3), partially suppresses an early initiation of cell differentiation induced by PEO-IAA. Taken together, these results suggest that auxin-mediated mitotic-to-endocycle transition might be part of the developmental programmes that balance cell proliferation and cell differentiation in the Arabidopsis root meristem.

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“…Many recent studies have shown that trichome cell size is often positively linked with their ploidy level (Hulskamp et al, 1994;Perazza et al, 1999;Sugimoto-Shirasu et al, 2005;Breuer et al, 2007). To test whether an increase in trichome cell size in gtl1 is accompanied by an increase in trichome ploidy, we visualized the nuclear DNA of fully mature trichomes isolated from the fourth and fifth leaves of 24-d-old plants using 49,6-diamidino-2-phenylindole (DAPI) staining.…”

Section: An Increase In Trichome Cell Size Is Accompanied By An Incrementioning

confidence: 99%

The Trihelix Transcription Factor GTL1 Regulates Ploidy-Dependent Cell Growth in theArabidopsisTrichome

et al. 2009

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Leaf trichomes in Arabidopsis thaliana develop through several distinct cellular processes, such as patterning, differentiation, and growth. Although recent studies have identified several key transcription factors as regulating early patterning and differentiation steps, it is still largely unknown how these regulatory proteins mediate subsequent trichome development, which is accompanied by rapid cell growth and branching. Here, we report a novel trichome mutation in Arabidopsis, which in contrast with previously identified mutants, increases trichome cell size without altering its overall patterning or branching. We show that the corresponding gene encodes a GT-2-LIKE1 (GTL1) protein, a member of the trihelix transcription factor family. GTL1 is present within the nucleus during the postbranching stages of trichome development, and its loss of function leads to an increase in the nuclear DNA content only in trichomes that have completed branching. Our data further demonstrate that the gtl1 mutation modifies the expression of several cell cycle genes and partially rescues the ploidy defects in the cyclin-dependent kinase inhibitor mutant siamese. Taken together, this study provides the genetic evidence for the requirement of transcriptional regulation in the repression of ploidy-dependent plant cell growth as well as for an involvement of GTL trihelix proteins in this regulation.

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BIN4, a Novel Component of the Plant DNA Topoisomerase VI Complex, Is Required for Endoreduplication in Arabidopsis

Cited by 109 publications

References 43 publications

A reference genome for common bean and genome-wide analysis of dual domestications

A reference genome for common bean and genome-wide analysis of dual domestications

Auxin modulates the transition from the mitotic cycle to the endocycle in Arabidopsis

The Trihelix Transcription Factor GTL1 Regulates Ploidy-Dependent Cell Growth in theArabidopsisTrichome

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