Bimetallic organic framework Cu/UiO-66 mediated “fluorescence turn-on” method for ultrasensitive and rapid detection of carcinoembryonic antigen (CEA)

Enhanced transformation of CO2 over microporous Ce-doped Zr metal–organic frameworks

“…4(c)], two peaks at around 182.9 eV and 185.3 eV were observed, which represents Zr 3d 5/2 of the zirconium atoms in Zr 6 clusters and Zr 3d 3/2 of the zirconium atoms in missing-linker defects, respectively. 30,50 Besides, with the introduction of Ce, the binding energies of Zr 3d shifted to lower energies [Fig. 4(c)], indicating the successful introduction of Ce into the material, which is consistent with the results from XRD.…”

“…4(a) shows that C 1s spectrum of all the four MOF materials exhibit three peaks, which are well recognized as being characteristics of C–C (284.8 eV), C–O (286.2 eV) and O–CO (288.8 eV). 50,51 Similarly, the O 1s region can be resolved into three peaks for all the catalysts [Fig. 4(b)].…”

A reagentless electrochemical immunosensor for sensitive detection of carcinoembryonic antigen based on the interface with redox probe-modified electron transfer wires and effectively immobilized antibody

“…The noise was the standard deviation (SD) of the blank current of the immunosensor before incubation of CEA. Supplementary Table S1 (SI) shows the comparison of the detection of CEA using different methods ( Li et al, 2017 ; Barman et al, 2018 ; Han et al, 2018 ; Ma et al, 2019 ; Li et al, 2020 ; Tang et al, 2020 ; Wu et al, 2021 ). The LOD is lower than that obtained using nanopipette analysis based on CEA aptamer modified magnetic Fe 3 O 4 -Au nanoparticles (Apt-MNPs), ( Tang et al, 2020 ), or fluorescence determination using CEA aptamer modified Cu 2+ -loaded UiO-66 metal-organic framework (Cu-UiO-66/CEA-Apt) ( Wu et al, 2021 ), or photoelectrochemical determination based on WO 3 @BiOI modified indium-tin oxide electrode followed with loading CdS NWs (CdS@BiOI@WO 3 /ITO) ( Han et al, 2018 ), or electrochemical determination based on immobilization of Ab on poly(ethyleneglycol)-NH 2 connected pyrenebutyric acid functionalized graphene/gold nanoparticles (BSA/Ab/AuNPs/PPYGR/GCE) ( Li et al, 2017 ), and Pd@Au@Pt nanocomposite/-COOH terminated reduced graphene oxide ( Barman et al, 2018 ).…”

“…Supplementary Table S1 (SI) shows the comparison of the detection of CEA using different methods ( Li et al, 2017 ; Barman et al, 2018 ; Han et al, 2018 ; Ma et al, 2019 ; Li et al, 2020 ; Tang et al, 2020 ; Wu et al, 2021 ). The LOD is lower than that obtained using nanopipette analysis based on CEA aptamer modified magnetic Fe 3 O 4 -Au nanoparticles (Apt-MNPs), ( Tang et al, 2020 ), or fluorescence determination using CEA aptamer modified Cu 2+ -loaded UiO-66 metal-organic framework (Cu-UiO-66/CEA-Apt) ( Wu et al, 2021 ), or photoelectrochemical determination based on WO 3 @BiOI modified indium-tin oxide electrode followed with loading CdS NWs (CdS@BiOI@WO 3 /ITO) ( Han et al, 2018 ), or electrochemical determination based on immobilization of Ab on poly(ethyleneglycol)-NH 2 connected pyrenebutyric acid functionalized graphene/gold nanoparticles (BSA/Ab/AuNPs/PPYGR/GCE) ( Li et al, 2017 ), and Pd@Au@Pt nanocomposite/-COOH terminated reduced graphene oxide ( Barman et al, 2018 ). The LOD is higher than the that obtained using sandwich-type electrochemical determination based on trimetallic yolk-shell Au@AgPt nanocubes loaded on amino-functionalized MoS 2 nanoflowers (MoS 2 NFs/Au@AgPt YNCs) and Au triangular nanoprisms (Au TNPs) ( Ma et al, 2019 ), and immunointerface using NH 2 -functionalized CEA aptamer on Fe-MOF modified with self-polymerized dopamine-decorated Au (NH 2 -aptamer/Au@PDA@Fe-MOF/GCE) ( Li et al, 2020 ).…”

Ultrahighly Sensitive Sandwich-Type Electrochemical Immunosensor for Selective Detection of Tumor Biomarkers

“…Carcinoembryonic antigen (CEA), one of glycoproteins in cell surfaces with a molecular weight of 180–200 kDa, was first discovered in human colon cancer in 1965 . In recent years, a large number of reports have confirmed that the overexpression of CEA is associated with many tumors, such as lung cancer, breast cancer, and colorectal cancer. , In addition, CEA is considered to be one of the tumor markers for clinical diagnosis of various tumors. In healthy adults, the concentration of CEA in blood is around 0–5 ng·mL –1 .…”