1957
DOI: 10.3181/00379727-94-23018 View full text |Buy / Rent full text
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Abstract: 78EXCRETION OF BILE ACIDS AND CHOLESTEROL and specificity would apply to the in vitro method reported by Schizume and associatesThe dose range for submasimal responses was 100 fold in the method using intact frogs. With the isolated preparations the range was only 2 fold. A long range for submasimal responses is considered desirable for a bioassay since it permits comparison between standard and unknown even though their potencies may vary considerably.As a measure of the variability of the response to a given… Show more

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“…After BF, hepatic cholesterol synthesis (22,(32)(33)(34)(35) and bile acid synthesis (22,35,(36)(37)(38)(39)(40) are increased many times. After IB, the same increases are seen in cholesterol (14,(41)(42)(43) and bile acid (43,44) The possibility that the hepatic atrophy of pes had been reduced by BF or IB was not supported by quantitative histopathologic analyses of hepatocyte size.…”
Section: Nsmentioning
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“…After BF, hepatic cholesterol synthesis (22,(32)(33)(34)(35) and bile acid synthesis (22,35,(36)(37)(38)(39)(40) are increased many times. After IB, the same increases are seen in cholesterol (14,(41)(42)(43) and bile acid (43,44) The possibility that the hepatic atrophy of pes had been reduced by BF or IB was not supported by quantitative histopathologic analyses of hepatocyte size.…”
Section: Nsmentioning
“…In animals with a total bile fistula, bile acid synthesis is enhanced (1,2). Furthermore, it has been demonstrated in the Rhesus monkey that bile acid synthesis in animals with an intact EHC (normal state) is low but increases in proportion to bile salt loss produced by a partial bile fistula (1).…”
mentioning
“…This mechanism explained the rapid predominance in bile of any administered bile acid (8). During partial or total interruption of the enterohepatic circulation of bile acids with cholestyramine or bile diversion bile acid synthesis increased (9)(10)(11)(12) due to apparent derepression. These data obtained in rats were confirmed by work in primates (13,14) and in humans (15)(16)(17)(18)(19)(20)(21)(22)(23) using both bile acid depletion and administration.…”
Section: Introductionmentioning