Bilharziome testiculaire à Schistosomia haematobium : à propos de deux observations

Ondo, Cyrille Zé; Sarr, A.; Sow, Yaya; Thiam, Ibou; Fall, B.; Sow, D.; Thiam, Alioune Badara; Diao, Bo; Fall, Papa Ahmed; Gaye, Gueye; Ndoye, Alain Khassim; Bâ, M.; Diagne, B.A.

doi:10.1016/j.purol.2013.04.016

Cited by 9 publications

(11 citation statements)

References 4 publications

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“…The increased size of the testes could presumably be the consequence of numerous eggs trapped in that organ or/and the inflammation induced by their presence in the testes. The presence of S. haematobium or S. mansoni ova in the testes has effectively been reported in men living in SCH-endemic areas or tourists who have visited these areas [ 14 , 19 , 21 – 23 , 36 ]. Schistosoma ova trapped in the testes directly damages the testicular tissue through inflammation and granuloma formation [ 37 ], thus impairing testicular steroidogenesis.…”

Section: Discussionmentioning

confidence: 99%

Reduction of testosterone levels in Schistosoma haematobium- or Schistosoma mansoni-infected men: a cross-sectional study in two schistosomiasis-endemic areas of the Adamawa region of Cameroon

et al. 2022

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Background The incidence of schistosomiasis‐induced male reproductive dysfunction and infertility is probably underestimated compared to female genital schistosomiasis. This study aimed to investigate the impact of Schistosoma haematobium or S. mansoni infection on the reproductive function of men of reproductive age in Tibati and Wouldé, two endemic schistosomiasis areas in the Adamawa region of Cameroon. Methods A total of 89 men of reproductive age (range 14–56 years) from two localities were enrolled in the study, with 51 in Tibati and 38 in Wouldé. Each participant was submitted to a questionnaire to document data on sociodemographic and stream contact behaviors. A medical examination was performed to measure the testes’ circumference and evaluate genital tract pathologies. Stool and urine samples were collected and screened for the presence of S. haematobium or S. mansoni ova. Blood serum was used to assess the levels of transaminases and testosterone. Results Schistosoma haematobium was present only in Tibati, with a prevalence of 31.37%. The S. mansoni prevalence was 3.92% at Tibati and 44.71% at Wouldé. The intensity of infection was 22.12 ± 9.57 eggs/10 mL for S. haematobium and 128.10 ± 3.76 epg for S. mansoni. Serum transaminase activity and the mean testicular circumference of Schistosoma-positive individuals were close to Schistosoma-negative individuals. However, the testes size was more prominent in S. mansoni-positive individuals than in S. haematobium-positive individuals (P < 0.05). The serum testosterone levels of S. haematobium- and S. mansoni-positive men were significantly reduced by 56.07% (P < 0.001) and 51.94% (P < 0.01), respectively, in comparison to those of Schistosoma-negative men. A significant and negative correlation was established between schistosomiasis and the low serum testosterone level. Male genital tract pathologies such as scrotal abnormalities, varicocele, nodular epididymis, inguinal hernia, and hydrocele were recorded in both Schistosoma-positive and Schistosoma-negative men. However, no significant link was established between schistosomiasis infection and these pathologies. Conclusion These results demonstrated that infection with S. haematobium or S. mansoni is associated with low production of the reproductive hormone testosterone and may be a significant cause of male infertility.

show abstract

Section: Discussionmentioning

confidence: 99%

Reduction of testosterone levels in Schistosoma haematobium- or Schistosoma mansoni-infected men: a cross-sectional study in two schistosomiasis-endemic areas of the Adamawa region of Cameroon

et al. 2022

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show abstract

“…The increase size of the testes could presumably be the consequence of numerous eggs trapped in that organ or / and the in ammation induces by their presence in the testes. The presence of S. haematobium or S. mansoni ova in the testes has effectively been reported in men living in SCH-endemic areas or tourists who have visited these areas [14,19,[21][22][23]36]. Schistosoma ova in the testes induces a direct damage of the testicular tissue by bilharzial in ammation and granuloma formation [37] that could impair with the testicular steroidogenesis.…”

Section: Discussionmentioning

confidence: 99%

“…The main ndings reported in patients who have travelled or lived in schistosomiasis endemic areas are swelling of scrotum and other genital organs, dilatation and calci cation of the prostate and seminal vesicles, haemospermia, hydrocele, changes in semen/ejaculate, infertility and urethral discharge [7,13]. Case reports have mentioned the presence of S. haematobium or S. mansoni eggs in male genital organs and semen of some young and adult patients [14][15][16][17][18][19][20][21][22][23][24]. Variation in the levels of sex hormones was also reported in some male patients with S. haematobium and / or S. mansoni [25][26][27][28][29].…”

Section: Introductionmentioning

confidence: 99%

Reduction of Testosterone Levels in Schistosoma Haematobium or Schistosoma Mansoni Infected Men: A Cross-Sectional Study in Two Schistosomiasis-Endemic Areas of the Adamawa Region of Cameroon

Jatsa

Femoe

Dongmo

et al. 2021

Preprint

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Background: The incidence of schistosomiasis‐induced male reproductive dysfunction and infertility is probably underestimated comparing to female genital schistosomiasis. This study aimed to investigate the impact of S. haematobium or S. mansoni infection on the reproductive function of adult men in Tibati and Wouldé, two schistosomiasis endemic areas in the Adamawa region of Cameroon.Methods: A total of 89 men in the reproductive age (range: 14 – 56 years) from two localities were enrolled in the study with 51 in Tibati and 38 in Wouldé. Each participant was submitted to a questionnaire to document data on sociodemographic and stream contact behaviors. A medical examination was performed to measure the circumference of the testes and to evaluate genital tract pathologies. Stool and urine samples were collected and screened for the presence of S. haematobium or S. mansoni ova. Blood serum was use to evaluate the level of transaminases and testosterone.Results: S. haematobium was present only in Tibati with a prevalence of 31.37%. S. mansoni prevalence was 3.92% at Tibati and 44.71% in Wouldé. The intensity of infection was 22.12 ± 9.57 eggs/10 mL for S. haematobium and 128.10 ± 3.76 epg for S. mansoni. Serum transaminases activity and the mean testicular circumference of Schistosoma-positive individuals were close to those of negative ones. The testes size was however higher in S. mansoni-positive individuals than in S. haematobium-positive ones (P < 0.05). The serum testosterone level of S. haematobium and S. mansoni-positive men was significantly reduced by 56.07% (P < 0.001) and 51.94% (P < 0.01) respectively in comparison to that of Schistosoma-negative ones. A significant and negative correlation was established between schistosomiasis and the low level of serum testosterone. Male genital tract pathologies such as scrotal abnormalities, varicocele, nodular epididymis, inguinal hernia and hydrocele were recorded in both Schistosoma-positive and Schistosoma-negative men. However, no significant link was established between schistosomiasis infection and these pathologies.Conclusion: These results demonstrated that infection with S. haematobium or S. mansoni is associated with a low production of the reproductive hormone testosterone, and may be a major cause of male infertility.

show abstract

“…The increased size of the testes could presumably be the consequence of numerous eggs trapped in that organ or/and the in ammation induced by their presence in the testes. The presence of S. haematobium or S. mansoni ova in the testes has effectively been reported in men living in SCH-endemic areas or tourists who have visited these areas [14,19,[21][22][23]36]. Schistosoma ova in the testes induces direct damage to the testicular tissue by bilharzial in ammation and granuloma formation [37], which could impair testicular steroidogenesis.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Reduction of testosterone levels in Schistosoma haematobium- or Schistosoma mansoni-infected men: a cross-sectional study in two schistosomiasis-endemic areas of the Adamawa region of Cameroon

Jatsa

Femoe

Dongmo

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: The incidence of schistosomiasis‐induced male reproductive dysfunction and infertility is probably underestimated compared to female genital schistosomiasis. This study aimed to investigate the impact of S. haematobium or S. mansoni infection on the reproductive function of adult men in Tibati and Wouldé, two schistosomiasis endemic areas in the Adamawa region of Cameroon.Methods: A total of 89 men of reproductive age (range: 14 – 56 years) from two localities were enrolled in the study, with 51 in Tibati and 38 in Wouldé. Each participant was submitted to a questionnaire to document data on sociodemographic and stream contact behaviors. A medical examination was performed to measure the circumference of the testes and to evaluate genital tract pathologies. Stool and urine samples were collected and screened for the presence of S. haematobium or S. mansoni ova. Blood serum was used to evaluate the levels of transaminases and testosterone.Results: S. haematobium was present only in Tibati, with a prevalence of 31.37%. The S. mansoni prevalence was 3.92% at Tibati and 44.71% in Wouldé. The intensity of infection was 22.12 ± 9.57 eggs/10 mL for S. haematobium and 128.10 ± 3.76 epg for S. mansoni. Serum transaminase activity and the mean testicular circumference of Schistosoma-positive individuals were close to those of Schistosoma-negative individuals. However, the testes size was higher in S. mansoni-positive individuals than in S. haematobium-positive individuals (P < 0.05). The serum testosterone levels of S. haematobium- and S. mansoni-positive men were significantly reduced by 56.07% (P < 0.001) and 51.94% (P < 0.01), respectively, in comparison to those of Schistosoma-negative men. A significant and negative correlation was established between schistosomiasis and the low level of serum testosterone. Male genital tract pathologies such as scrotal abnormalities, varicocele, nodular epididymis, inguinal hernia and hydrocele were recorded in both Schistosoma-positive and Schistosoma-negative men. However, no significant link was established between schistosomiasis infection and these pathologies.Conclusion: These results demonstrated that infection with S. haematobium or S. mansoni is associated with low production of the reproductive hormone testosterone and may be a major cause of male infertility.

show abstract

Bilharziome testiculaire à Schistosomia haematobium : à propos de deux observations

Cited by 9 publications

References 4 publications

Reduction of testosterone levels in Schistosoma haematobium- or Schistosoma mansoni-infected men: a cross-sectional study in two schistosomiasis-endemic areas of the Adamawa region of Cameroon

Reduction of testosterone levels in Schistosoma haematobium- or Schistosoma mansoni-infected men: a cross-sectional study in two schistosomiasis-endemic areas of the Adamawa region of Cameroon

Reduction of Testosterone Levels in Schistosoma Haematobium or Schistosoma Mansoni Infected Men: A Cross-Sectional Study in Two Schistosomiasis-Endemic Areas of the Adamawa Region of Cameroon

Reduction of testosterone levels in Schistosoma haematobium- or Schistosoma mansoni-infected men: a cross-sectional study in two schistosomiasis-endemic areas of the Adamawa region of Cameroon

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