Current Opinion in Lipidology volume 27, issue 3, P295-301 2016 DOI: 10.1097/mol.0000000000000303 View full text
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Marleen Schonewille, Jan Freark de Boer, Albert K. Groen

Abstract: Modulation of FXR activity appears to be a potent target, not only for improving bile salt homeostasis, but also to improve lipid metabolism. Depending on the metabolic context both, FXR agonists as well as antagonists, could prove to be of therapeutic benefit.