2013
DOI: 10.1038/nrgastro.2013.151
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Abstract: The intracellular nuclear receptor farnesoid X receptor and the transmembrane G protein-coupled receptor TGR5 respond to bile acids by activating transcriptional networks and/or signalling cascades. These cascades affect the expression of a great number of target genes relevant for bile acid, cholesterol, lipid and carbohydrate metabolism, as well as genes involved in inflammation, fibrosis and carcinogenesis. Pregnane X receptor, vitamin D receptor and constitutive androstane receptor are additional nuclear r… Show more

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Cited by 569 publications
(537 citation statements)
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References 172 publications
(189 reference statements)
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“…Increased bile salt content of the hepatic remnant is apparent after 1 h, and this allows activation of hepatocytic Fxr. The elevations of circulating and hepatic bile salts are transient and normalize approximately 2 days after 70 % PHx in mice [25].…”
Section: Bile Salts and Liver Regenerationmentioning
confidence: 97%
See 4 more Smart Citations
“…Increased bile salt content of the hepatic remnant is apparent after 1 h, and this allows activation of hepatocytic Fxr. The elevations of circulating and hepatic bile salts are transient and normalize approximately 2 days after 70 % PHx in mice [25].…”
Section: Bile Salts and Liver Regenerationmentioning
confidence: 97%
“…FXR controls bile salt homeostasis by coordinating synthesis, uptake, conjugation and secretion of bile salts. Regulation of bile salt synthesis occurs primarily at the level of cholesterol-7a-hydroxylase (CYP7A1) transcription and involves FXR expressed in the terminal ileum and the liver [25] (Fig. 1).…”
Section: Bile Salt Signalingmentioning
confidence: 99%
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