Bilateral hippocampal increase following first-episode psychosis is associated with good clinical, functional and cognitive outcomes

Abstract

BHI occurs in a minority of patients following their first psychotic episode and is associated with good outcome across clinical, functional and cognitive domains.

Pattern of activation during delayed matching to sample task predicts functional outcome in people at ultra high risk for psychosis

“…A relationship between neuroimaging measures and functional outcomes is consistent with data from studies in patients with first episode psychosis (Lappin et al, 2014), and in chronic schizophrenia (Mitelman et al, 2005). More recently, functional outcome in UHR subjects has been found to be linked to the level of activation in inferior frontal cortex, the hippocampus, putamen and thalamus (Allen et al, 2014), and to thalamic glutamate levels (Allen et al, 2014).…”

The neurobiology of transition to psychosis

“…30 Grey matter increase in patients with psychosis has now been reported in both crosssectional studies of treated [31][32][33] and neuroleptic-naive patients 34,35 and in longitudinal studies [36][37][38][39][40][41] in which patients were treated with antipsychotics. Dukart and colleagues report that a medium to large effect size of increase in grey matter tissue can occur even before the onset of psychosis in individuals with ARMS.…”

“…Schauffenberger and colleagues 39 reported no significant grey matter loss in nonremitting patients with FEP, but those who remitted showed a pattern of grey matter increase in regions that showed baseline deficits (insula, superior temporal gyrus). Lappin and colleagues 37 noted that 29% of medicated patients with FEP showed a bilateral hippocampal volume increase over a 6-year period; this was associated with better clinical and functional outcome. A more directly relevant observation is the association between higher occipital grey matter tissue and a favourable treatment response in individuals with psychosis.…”

The Effect of Antipsychotic Treatment on Cortical Gray Matter Changes in Schizophrenia: Does the Class Matter? A Meta-analysis and Meta-regression of Longitudinal Magnetic Resonance Imaging Studies

“…Meta-regressions were performed when at least 10 independent studies were available for the outcome of interest. Thus, the potential moderating impact on GM changes of such variables as patient's IQ [reported only in three studies (20,36,37)] or DUP [reported only in three studies (26,38,39)] was not considered.…”