Bilateral Herpetic Keratitis in Atopic Dermatitis

Maeno, Sayo; Koh, Shizuka

doi:10.1016/j.mayocp.2019.04.026

“…Skin barriers deteriorate from atopy in patients with atopic dermatitis, and recurrent eczema occurs in sensitive areas such as the eyelid. 1 Even itching caused by secondary causes, such as a larva settling in the eye, can trigger an atopic dermatitis attack, as seen with our patient. 2 We wanted to share this case to emphasize the importance of mucosal examination in dermatologic diseases.…”

supporting

confidence: 55%

Foreign Body in the Mucosa in a Patient With Atopic Dermatitis

Yürekli¹,

Akmaz²

2020

Mayo Clinic Proceedings

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“…This was demonstrated in an openlabel multicentre study with 158 patients where preservative-free tafluprost was better tolerated compared to latanoprost containing preservative solution [11]. It is important to note, however, that a study by Jess T Whitson et al [12] found no significant difference in tear break-up time and corneal staining among prostaglandins with different BAK concentrations which included bimatoprost (0.005% BAK), latanoprost (0.02% BAK), and travoprost (safZia) [12].…”

Section: Non-ocular Adverse Reactions Of Prostaglandinsmentioning

confidence: 97%

Bilateral Herpes Simplex Keratitis Presenting as Bilateral Ulcerative Blepharo-Keratoconjunctivitis: A Rarity or Pattern

Zwerling

¹

2021

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We report a case of an immunocompetent 77-year-old Caucasian female presenting with bilateral herpes simplex keratitis masquerading as bilateral ulcerative blepharo-keratoconjunctivitis. Most cases of herpes simplex keratitis present unilaterally and uncommon occurrences of bilateral cases range from 1.3% to 10.9%. In literature, bilateral herpes simplex keratitis has been reported for patients with atopic disease, corticosteroid use, autoimmune diseases, and UV A light exposure. Our patient had none of these conditions, but she did suffer from type 2 diabetes mellitus that was well-controlled. She had no prior history of known herpes simplex disease and tested negative for COVID 19. To date, this is the third reported bilateral herpes simplex keratitis case and the second reported in an elderly patient with shared history of prostaglandin usage and presence of diabetes mellitus. Our rationale for reporting this case is that while it seems to be a rare presentation it could be establishing a pattern. The study explores the relationship between a prostaglandin and HSV activation that may allow viral entrance due to epithelial breakdown. Since our patient did not have any of the previously reported immunocompromised states that have been associated with bilateral herpes keratitis, this case may represent a new pattern for HSV infection. Our clinical methods indicate that close follow-up was crucial to identifying the patient's eye condition as a bilateral herpes simplex keratitis. Due to this potential pattern of disease, a revised management approach may benefit similar patients by selecting alternative treatments for glaucoma early in the disease presentation.

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“…This was demonstrated in an openlabel multicentre study with 158 patients where preservative-free tafluprost was better tolerated compared to latanoprost containing preservative solution [11]. It is important to note, however, that a study by Jess T Whitson et al [12] found no significant difference in tear break-up time and corneal staining among prostaglandins with different BAK concentrations which included bimatoprost (0.005% BAK), latanoprost (0.02% BAK), and travoprost (safZia) [12].…”

Section: Non-ocular Adverse Reactions Of Prostaglandinsmentioning

confidence: 97%

Causal Relationship Between Chronic Upper Respiratory Infections and Benign Enlargement of Subarachnoid Spaces

Collins¹

2021

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We report a case of an immunocompetent 77-year-old Caucasian female presenting with bilateral herpes simplex keratitis masquerading as bilateral ulcerative blepharo-keratoconjunctivitis. Most cases of herpes simplex keratitis present unilaterally and uncommon occurrences of bilateral cases range from 1.3% to 10.9%. In literature, bilateral herpes simplex keratitis has been reported for patients with atopic disease, corticosteroid use, autoimmune diseases, and UV A light exposure. Our patient had none of these conditions, but she did suffer from type 2 diabetes mellitus that was well-controlled. She had no prior history of known herpes simplex disease and tested negative for COVID 19. To date, this is the third reported bilateral herpes simplex keratitis case and the second reported in an elderly patient with shared history of prostaglandin usage and presence of diabetes mellitus. Our rationale for reporting this case is that while it seems to be a rare presentation it could be establishing a pattern. The study explores the relationship between a prostaglandin and HSV activation that may allow viral entrance due to epithelial breakdown. Since our patient did not have any of the previously reported immunocompromised states that have been associated with bilateral herpes keratitis, this case may represent a new pattern for HSV infection. Our clinical methods indicate that close follow-up was crucial to identifying the patient's eye condition as a bilateral herpes simplex keratitis. Due to this potential pattern of disease, a revised management approach may benefit similar patients by selecting alternative treatments for glaucoma early in the disease presentation.

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Bilateral Herpetic Keratitis in Atopic Dermatitis

Cited by 3 publications

References 4 publications

Foreign Body in the Mucosa in a Patient With Atopic Dermatitis

Foreign Body in the Mucosa in a Patient With Atopic Dermatitis

Bilateral Herpes Simplex Keratitis Presenting as Bilateral Ulcerative Blepharo-Keratoconjunctivitis: A Rarity or Pattern

Causal Relationship Between Chronic Upper Respiratory Infections and Benign Enlargement of Subarachnoid Spaces

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