Bilateral eyelid necrosis with dermal matrix reconstruction and skin grafting

Pereira, Carlos Miguel; Barra, Irene Daher; Badaró, Kerly Abraão

doi:10.5935/2177-1235.2021rbcp0070

Cited by 1 publication

(3 citation statements)

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“…Severe burns can cause serious skin damage, and managing the aesthetic outcomes and potential infections of these injuries is critical ( 16 , 21 , 24 , 31 , 33 , 44 , 62 , 64 , 66 – 68 , 99 , 123 , 139 , 140 , 147 , 154 , 162 , 173 – 176 ). Full-thickness and some deep partial-thickness burns require skin transplantation ( 177 – 180 ).…”

Section: Burns and Woundsmentioning

confidence: 99%

“…As an acellular skin substitute, ADM incorporates into the wound and is gradually vascularized by the wound bed allowing infiltration of fibroblasts ( 16 , 21 , 24 , 31 , 33 , 44 , 62 , 64 , 66 – 68 , 99 , 123 , 139 , 140 , 147 , 154 , 162 , 173 – 176 ). These events protect the wound and prevent granulation tissue and scar formation ( Figure 1F ) ( 181 ).…”

Section: Burns and Woundsmentioning

confidence: 99%

“…Other studies on the effects of ADM on deep burns have yielded promising results ( 16 , 21 , 24 , 31 , 33 , 44 , 62 , 64 , 66 – 68 , 99 , 123 , 139 , 140 , 147 , 154 , 162 , 173 – 176 ).…”

Section: Burns and Woundsmentioning

confidence: 99%

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Acellular dermal matrix in reconstructive surgery: Applications, benefits, and cost

Mohammadyari

Parvin²,

Khorvash³

et al. 2023

Front. Transplant.

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Modern tissue engineering has made substantial advancements that have revolutionized plastic surgery. Acellular dermal matrix (ADM) is an example that has gained considerable attention recently. ADM can be made from humans, bovines, or porcine tissues. ADM acts as a scaffold that incorporates into the recipient tissue. It is gradually infiltrated by fibroblasts and vascularized. Fortunately, many techniques have been used to remove cellular and antigenic components from ADM to minimize immune system rejection. ADM is made of collagen, fibronectin, elastin, laminin, glycosaminoglycans, and hyaluronic acid. It is used in critical wounds (e.g., diabetic wounds) to protect soft tissue and accelerate wound healing. It is also used in implant-based breast reconstruction surgery to improve aesthetic outcomes and reduce capsule contracture risk. ADM has also gained attention in abdominal and chest wall defects. Some studies have shown that ADM is associated with less erosion and infection in abdominal hernias than synthetic meshes. However, its higher cost prevents it from being commonly used in hernia repair. Also, using ADM in tendon repair (e.g., Achilles tendon) has been associated with increased stability and reduced rejection rate. Despite its advantages, ADM might result in complications such as hematoma, seroma, necrosis, and infection. Moreover, ADM is expensive, making it an unsuitable option for many patients. Finally, the literature on ADM is insufficient, and more research on the results of ADM usage in surgeries is needed. This article aims to review the literature regarding the application, Benefits, and costs of ADM in reconstructive surgery.

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