Bilateral destruction of the ventrolateral orbital cortex produces allocentric but not egocentric spatial deficits in rats

Corwin, James V.; Fussinger, Mark; Meyer, Rainer-Peter; King, Von R.; Reep, Roger L.

doi:10.1016/0166-4328(94)90010-8

Cited by 62 publications

(45 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It should be noted, however, that our findings do not clearly establish the overall specificity of the hippocampus in mediating this task, and non-hippocampal regions (e.g., posterior parietal, orbitofrontal) might be expected to impact performance as well. In animal studies, Corwin et al (1994) demonstrated the potential relevance of orbitofrontal cortex to allocentric processing, although human studies have been less compelling (Galati et al 2000;Neggers et al 2006). The fact that performance on the Cube and Paper Test continued to predict hippocampal volume even after adding amygdala volume or total grey matter volume to the regression model is suggestive of a prominent role for the hippocampus.…”

Section: Discussionmentioning

confidence: 99%

Configural Cue Performance in Identical Twins Discordant for Posttraumatic Stress Disorder: Theoretical Implications for the Role of Hippocampal Function

Gilbertson

Williston

Paulus

et al. 2007

Biological Psychiatry

100

View full text Add to dashboard Cite

Background-A significant subgroup of individuals with posttraumatic stress disorder (PTSD) exhibits chronic, unremitting symptomatology that has also been associated with smaller hippocampal volume. The hippocampus plays a significant role in configural processing of contextual cues that facilitates context-appropriate extinction of conditioned fear. We test the hypothesis that hippocampus-based configural processing deficits are a pre-existing vulnerability factor for unremitting forms of PTSD.

show abstract

Section: Discussionmentioning

confidence: 99%

Configural Cue Performance in Identical Twins Discordant for Posttraumatic Stress Disorder: Theoretical Implications for the Role of Hippocampal Function

Gilbertson

Williston

Paulus

et al. 2007

Biological Psychiatry

100

View full text Add to dashboard Cite

show abstract

“…For example, orbitofrontal cortex damage in non-human primates and rats does not impair spatial reversal learning (Corwin, Fussinger, Meyer, King, & Reep, 1994;Meunier, Bachevalier, & Mishkin, 1997;Nonneman, Voigt, & Kolb, 1974). To date, the evidence indicates that the orbitofrontal cortex supports reversal learning for odor, tactile or visual cue information (Bohn et al, 2003;Chudasasma & Robbins, 2003;Ferry et al, 2000;McAlonan & Brown, 2003;Rolls et al, 1994;Meunier et al, 1997;Schoenbaum et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

The involvement of the orbitofrontal cortex in learning under changing task contingencies

Kim

Ragozzino

2005

Neurobiology of Learning and Memory

166

158

View full text Add to dashboard Cite

Previous investigations examining the rat prefrontal cortex subregions in attentional-set shifting have commonly employed two-choice discriminations. To better understand how varying levels of difficulty influence the contribution of the prefrontal cortex to learning, the present studies examined the effects of orbitofrontal cortex inactivation in a two-or four-choice odor reversal learning test. Long-Evans rats were trained to dig in cups that contained distinct odors. In the twochoice odor discrimination, one odor cup was always associated with a cereal reinforcement in acquisition while the opposite odor cup was associated with a cereal reinforcement in reversal learning. In the four-choice odor discrimination, an additional two cups containing distinct odors were used that were never associated with reinforcement in acquisition or reversal learning. Bilateral infusions of the GABA-A agonist, muscimol (0.5 μg) into the orbitofrontal cortex did not impair acquisition of either the two-or four-choice discrimination task. However, muscimol infusions into the orbitofrontal cortex impaired two-and four-choice reversal learning. In the twochoice odor reversal, muscimol treatment selectively increased perseverative errors. In the fourchoice odor reversal, muscimol treatment increased perseverative, regressive, as well as irrelevant errors. These findings suggest that the orbital prefrontal cortex not only enables task switching by supporting the initial inhibition of a previously relevant choice pattern, but under increasing task demands also enables the reliable execution of a new choice pattern and reduction of interference to irrelevant stimuli.

show abstract

“…Likewise, OPFC lesions in rats do not impair learning egocentric and allocentric spatial tasks (Corwin et al 1994); a spatial location task (Ragozzino and Kesner 1999); and a go, no-go discrimination task (Schoenbaum et al 2002). Overall, these data indicate that OPFC lesions do not impair the rats' ability to acquire spatial discrimination tasks.…”

Section: Effects Of Opfc Lesion On Performance During Acquisitionmentioning

confidence: 75%

“…However, as discussed by Eichenbaum et al (1983), and Ragozzino and Kesner (1999), it is likely that task differences might account for these deviating results, as some tasks are spatial, whereas other ones are nonspatial. For instance, lesions of medial prefrontal cortex cause performance deficits in spatial discrimination tasks (e.g., Kolb et al 1974;Eichenbaum et al 1983;Ragozzino and Kesner 1999), whereas lesions of OPFC do not impair learning of spatial reversals in a Grice box (Kolb et al 1974), a cheeseboard (Corwin et al 1994), and a Y-maze (Eichenbaum et al 1983) task. On the other hand, there is consistent evidence that OPFC lesions impair performance in nonspatial tasks (Rolls et al 1994;Rolls 1996;Gallagher et al 1999;Elliott et al 2000;Ferry et al 2000;Schoenbaum et al 2002).…”

Section: Effects Of Opfc Lesion On Performance After Serial Changes Omentioning

confidence: 99%

“…OPFC-lesioned rats are mildly impaired at acquiring new reinforcement contingencies in a continuous delayed-nonmatching-to-sample task (Otto and Eichenbaum 1992), but not in a go, no-go discrimination task (Schoenbaum et al 2002). Furthermore, OPFC lesions in rats did not impair reversal learning in a Y-maze spatial alternation task (Eichenbaum et al 1983) and a cheeseboard task (Corwin et al 1994), but did so partially in olfactory discrimination tasks (Ferry et al 2000;Schoenbaum et al 2002). Besides, OPFC lesions in rats were found to impair conditioned responding after reinforcer devaluation ) and performance in a T-maze task under extinction conditions (De Bruin 1994).…”

mentioning

confidence: 94%

See 1 more Smart Citation

Orbital Prefrontal Cortex and Guidance of Instrumental Behavior of Rats by Visuospatial Stimuli Predicting Reward Magnitude

Bohn¹,

Giertler²,

Hauber³

2003

Learn. Mem.

View full text Add to dashboard Cite

The orbital prefrontal cortex (OPFC) is part of a circuitry mediating the perception of reward and the initiation of adaptive behavioral responses. We investigated whether the OPFC is involved in guidance of the speed of instrumental behavior by visuospatial stimuli predictive of different reward magnitudes. Unoperated rats, sham-lesioned rats, and rats with bilateral lesions of the OPFC by N-methyl-D-aspartate (NMDA) were trained in a visuospatial discrimination task. The task required a lever press on the illuminated lever of two available to obtain a food reward. Different reward magnitudes were permanently assigned to lever presses to respective sides of the operant chamber; that is, responses to one lever (e.g., the left one) were always rewarded with one pellet and responses to the other lever with five pellets. On each trial, the position of the illuminated lever was pseudorandomly determined in advance. Results revealed that OPFC lesions did not impair acquisition of the task, as the speed of conditioned responses was significantly shorter with expectancy of a high reward magnitude. In addition, during reversal, shift and reshift of lever position-reward magnitude contingencies and under extinction conditions, performance of the OPFC-lesioned and control groups did not differ. It is concluded that the OPFC in rats might not be critical for adapting behavioral responses to changes of stimulus-reward magnitude contingencies signaled by visuospatial cues.

show abstract

Bilateral destruction of the ventrolateral orbital cortex produces allocentric but not egocentric spatial deficits in rats

Cited by 62 publications

References 26 publications

Configural Cue Performance in Identical Twins Discordant for Posttraumatic Stress Disorder: Theoretical Implications for the Role of Hippocampal Function

Configural Cue Performance in Identical Twins Discordant for Posttraumatic Stress Disorder: Theoretical Implications for the Role of Hippocampal Function

The involvement of the orbitofrontal cortex in learning under changing task contingencies

Orbital Prefrontal Cortex and Guidance of Instrumental Behavior of Rats by Visuospatial Stimuli Predicting Reward Magnitude

Contact Info

Product

Resources

About