Bilateral and Multinodular Signet-Ring Stromal Tumor of the Ovary

Abstract

We report a rare example of signet-ring stromal tumor that is bilateral and multinodular mimicking a Krukenberg tumor. Awareness of this unusual presentation can help prevent incorrect diagnosis.

Primary peritoneal serous carcinoma with signet ring cells

“…These tumors are usually large and cystic, with turbid liquid seen within the cavity (Forde et al, 2010;Levine et al, 2004;Balci et al, 2010). Although mucous tumor cells were found in the ascites of this patient, the provisional diagnosis of Gynecologic Oncology Reports 1 (2011) 4-5 gastric cancer was made as the clinical features described above had not been described previously, rather than a peritoneal mucus carcinoma.…”

Signet Ring Stromal Cell Tumor: A Legitimate (Benign) Mimic of Krukenberg Tumor

“…Preoperative serum tumor markers, including carcinoembryonic antigen, CA 125, CA 19-9, and, in one case, squamous cell carcinoma antigen, have been within normal limits. [1][2][3][4][5][6][7][8][9] GROSS AND MICROSCOPIC FINDINGS Signet ring stromal cell tumors range from 3.0 to 13.0 cm. They are circumscribed, solid, gray-tan, white, brown, or yellow tumors with variable firmness.…”

“…A rim of compressed ovarian parenchyma may be seen peripheral to the tumor, and the serosa of the ovary is typically smooth with no evidence of surface involvement. 1,[3][4][5][6][7][8][9] Microscopically, SRSCTs are composed of cells with a signet ring-like appearance, most frequently with a single cytoplasmic vacuole displacing the nucleus eccentrically ( Figure 1). The vacuoles are typically clear, but may contain faint pink material.…”

Oncogenic Activation of the Wnt/β-Catenin Signaling Pathway in Signet Ring Stromal Cell Tumor of the Ovary

“…1 SRSCT remains a very rare neoplasm with only 12 cases reported so far. [1][2][3][4][5][6][7][8][9][10] Except 1, all tumors occurred unilaterally in adult patients with ages ranging from 28 to 83 years. The tumor size varied from 3 to 13 cm.…”