2017
DOI: 10.1182/blood-2017-02-767293
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Abstract: BACH2, a B-cell-specific transcription factor, plays a critical role in oxidative stress-mediated drug resistance in mantle cell lymphoma (MCL); however, the biological functions of BACH2 and its regulation of B-cell malignancies in chronic hypoxic microenvironment have not been studied. Here, we found that silencing BACH2 led to not only increased tumor formation and colony formation but also increased tumor dispersal to spleen and bone marrow. Decreased BACH2 levels in patients were also correlated with bone… Show more

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Cited by 15 publications
(21 citation statements)
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“…Luciferase activity was measured using a Dual-Luciferase Reporter Assay System kit (Promega, Madison, WI, USA) as described before (11). The data were normalized and presented as the ratio of re y/Renilla luciferase activities.…”
Section: Luciferase Activity Assaymentioning
confidence: 99%
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“…Luciferase activity was measured using a Dual-Luciferase Reporter Assay System kit (Promega, Madison, WI, USA) as described before (11). The data were normalized and presented as the ratio of re y/Renilla luciferase activities.…”
Section: Luciferase Activity Assaymentioning
confidence: 99%
“…with manipulated Nalm-6 cells via tail vein (5 × 10 6 cells/mouse, n = 3/group). Seven days post transplantation, xenograft mice were humanely sacri ced; bone marrow (BM) and spleen (SP) cells were collected to analyze leukemia engraftment by determining the percentage of positive human CD19 (hCD19 + ) cells as previously described (11).…”
Section: Tumor Xenograft Modelmentioning
confidence: 99%
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“…The t(11; 14) (q13; q32) translocation leads to the constitutive overexpression of CCND1, which binds to cyclin-dependent kinases 4 and 6 (CDK4/6) and results in cell cycle disorder [2]. However, a subset of patients with MCL lack the t(11; 14) translocation and CCND1 expression; remarkably, CCND1 overexpression in mouse models is insufficient to induce spontaneous tumors [3], suggesting that other genetic or epigenetic events, signaling pathways, and microenvironmental alterations might be required for the initiation and progression of MCL [4, 5, 6, 7].…”
Section: Introductionmentioning
confidence: 99%