Bifidobacterium longum subsp. longum 51A Attenuates Signs of Inflammation in a Murine Model of Food Allergy

Santos, Spencer S.; Miranda, Vivian C.; Trindade, Luísa Martins; Cardoso, Valbert Nascimento; Reis, Diego Carlos dos; Cassali, Geovanni Dantas; Nicoli, Jacques R.; Cara, Denise Carmona; Martins, Flaviano S.

doi:10.1007/s12602-021-09846-9

Cited by 13 publications

(8 citation statements)

References 52 publications

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“…Oral administration of probiotic strains such as Lactobacillus and Bifidobacterium alleviated weight loss and reduced the levels of serum OVA-sIgE, intestinal Th2-type, and Th17-type cytokines. 24,25 The research is now focusing on the specific mechanism how probiotic strains alleviated FA. Probiotic strains could alleviate FA pathological symptoms by regulating the functionality of DC.…”

Section: Discussionmentioning

confidence: 99%

Probiotic strains alleviated OVA-induced food allergy in mice by regulating the gut microbiota and improving the level of indoleacrylic acid in fecal samples

Liu

Fang

et al. 2022

Food Funct.

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Section: Discussionmentioning

confidence: 99%

Probiotic strains alleviated OVA-induced food allergy in mice by regulating the gut microbiota and improving the level of indoleacrylic acid in fecal samples

Liu

Fang

et al. 2022

Food Funct.

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“…However, in some cases, the postbiotic does not work as well as the live bacterium, such as when inactivated Bifidobacterium longum subsp. longum 5 1A immunity produced beneficial effects in inflammation in a mouse model of food allergy [ 98 ]. This suggests that live bacteria have advantages that are unmatched by postbiotics.…”

Section: Postbiotics and Food Allergymentioning

confidence: 99%

Advances in the Study of Probiotics for Immunomodulation and Intervention in Food Allergy

Huang

Liang

et al. 2023

Molecules

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Food allergies are a serious food safety and public health issue. Soybean, dairy, aquatic, poultry, and nut products are common allergens inducing allergic reactions and adverse symptoms such as atopic dermatitis, allergic eczema, allergic asthma, and allergic rhinitis. Probiotics are assumed as an essential ingredient in maintaining intestinal microorganisms’ composition. They have unique physiological roles and therapeutic effects in maintaining the mucosal barrier, immune function, and gastrointestinal tract, inhibiting the invasion of pathogenic bacteria, and preventing diarrhea and food allergies. Multiple pieces of evidence reveal a significant disruptive effect of probiotics on food allergy pathology and progression mechanisms. Thus, this review describes the allergenic proteins as an entry point and briefly describes the application of probiotics in allergenic foods. Then, the role of probiotics in preventing and curing allergic diseases by regulating human immunity through intestinal flora and intestinal barrier, modulating host immune active cells, and improving host amino acid metabolism are described in detail. The anti-allergic role of probiotics in the function and metabolism of the gastrointestinal tract has been comprehensively explored to furnish insights for relieving food allergy symptoms and preventing food allergy.

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“…Some groups were treated with B. longum 5 1A . The probiotic bacterium B. longum 5 1A , from the culture collection of the Laboratory of Biotherapeutic Agents at ICB/UFMG, was isolated from fecal samples of healthy children and was cultivated as previously described (Santos et al, 2021;Vieira et al, 2016b). Briefly, mice were treated by oral gavage of a single 100 μL dose of suspension containing 1x10 9 CFU/mL B. longum 5 1A , or sterile saline every 48h during the infection period (Vieira et al, 2016b).…”

Section: Mouse Hepatitis Virus-3 (Mhv-3) Infectionmentioning

confidence: 99%

Gut microbiota from patients with COVID-19 cause alterations in mice that resemble post-COVID symptoms

Almeida

Engel

Ricci

et al. 2023

Preprint

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Long-term sequelae after Coronavirus disease (COVID)-19 are frequent and of major concern. SARS-CoV-2 infection affects the host's gut microbiota, which is linked with disease severity in patients with COVID-19. We report here that the gut microbiota of post-COVID subjects had a remarkable predominance of Enterobacteriaceae strains with antibiotic-resistance phenotype compared to healthy controls. Additionally, short-chain fatty acids (SCFA) levels were reduced in their feces. Fecal transplant from post-COVID subjects to germ-free mice led to lung inflammation and worst outcomes during pulmonary infection by multidrug-resistant Klebsiella pneumoniae. Transplanted mice also had poorer cognitive performance. Overall, we show prolonged impacts of SARS-CoV-2 infection in the gut microbiota that persist after subjects have cleared the virus. Together, these data demonstrate that the gut microbiota can directly contribute to post-COVID sequelae, suggesting that it may be a potential therapeutic target.

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Bifidobacterium longum subsp. longum 51A Attenuates Signs of Inflammation in a Murine Model of Food Allergy

Cited by 13 publications

References 52 publications

Probiotic strains alleviated OVA-induced food allergy in mice by regulating the gut microbiota and improving the level of indoleacrylic acid in fecal samples

Probiotic strains alleviated OVA-induced food allergy in mice by regulating the gut microbiota and improving the level of indoleacrylic acid in fecal samples

Advances in the Study of Probiotics for Immunomodulation and Intervention in Food Allergy

Gut microbiota from patients with COVID-19 cause alterations in mice that resemble post-COVID symptoms

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