Bidirectional differentiation of BMSCs induced by a biomimetic procallus based on a gelatin-reduced graphene oxide reinforced hydrogel for rapid bone regeneration

Jiao, Delong; Ao, Zheng; Liu, Yang; Zhang, Xiangkai; Wang, Xiao; Wu, Jiannan; She, Wen-Jun; Lv, Kaige; Cao, Lingyan; Jiang, Xinquan

doi:10.1016/j.bioactmat.2020.12.003

Cited by 47 publications

(34 citation statements)

References 71 publications

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“…In a calvarial defect in vivo, bi-differentiation of MSC promoted rapid bone regeneration. 109 In this context, several studies have tested graphene coated dental implants in vitro and in vivo and demonstrated better cytocompatibilty, cellular attachment and proliferation, higher osteogenic differentiation of stem cells, antibacterial activity and bone formation. 110,111 Currently, the trend has shifted from bioinert to bioactive biomaterials for the regulation of local inflammatory environment to promote bone healing.…”

Section: Role Of Surface Coatings and Delivery Systemsmentioning

confidence: 99%

Modulation of immune-inflammatory responses through surface modifications of biomaterials to promote bone healing and regeneration

et al. 2021

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Control of inflammation is indispensable for optimal oral wound healing and tissue regeneration. Several biomaterials have been used to enhance the regenerative outcomes; however, the biomaterial implantation can ensure an immune-inflammatory response. The interface between the cells and the biomaterial surface plays a critical role in determining the success of soft and hard tissue regeneration. The initial inflammatory response upon biomaterial implantation helps in tissue repair and regeneration, however, persistant inflammation impairs the wound healing response. The cells interact with the biomaterials through extracellular matrix proteins leading to protein adsorption followed by recruitment, attachment, migration, and proliferation of several immune-inflammatory cells. Physical nanotopography of biomaterials, such as surface proteins, roughness, and porosity, is crucial for driving cellular attachment and migration. Similarly, modification of scaffold surface chemistry by adapting hydrophilicity, surface charge, surface coatings, can down-regulate the initiation of pro-inflammatory cascades. Besides, functionalization of scaffold surfaces with active biological molecules can down-regulate pro-inflammatory and pro-resorptive mediators’ release as well as actively up-regulate anti-inflammatory markers. This review encompasses various strategies for the optimization of physical, chemical, and biological properties of biomaterial and the underlying mechanisms to modulate the immune-inflammatory response, thereby, promoting the tissue integration and subsequent soft and hard tissue regeneration potential of the administered biomaterial.

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Section: Role Of Surface Coatings and Delivery Systemsmentioning

confidence: 99%

Modulation of immune-inflammatory responses through surface modifications of biomaterials to promote bone healing and regeneration

et al. 2021

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“…Since its discovery in 2004, graphene has attracted extensive interest, and much research has been carried out to study its physical and chemical properties and explore its applications [1][2][3]. The peculiar optical, mechanical, and electrical properties of graphene make it promising in many fields, such as material science [3], biomedicine [4,5], environmental treatment [6,7], and energy [8,9]. In particular, graphene plays an important role in the fight against COVID-19, and it has recently inspired novel technologies to defeat the pandemic [10,11].…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Graphene and Conductive Polymer Composites for Supercapacitor Electrodes: A Review

2021

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Supercapacitors (SCs) have generated a great deal of interest regarding their prospects for application in energy storage due to their advantages such as long life cycles and high-power density. Graphene is an excellent electrode material for SCs due to its high electric conductivity and highly specific surface area. Conductive polymers (CPs) could potentially become the next-generation SC electrodes because of their low cost, facile synthesis methods, and high pseudocapacitance. Graphene/CP composites show conspicuous electrochemical performance when used as electrode materials for SCs. In this article, we present and summarize the synthesis and electrochemical performance of graphene/CP composites for SCs. Additionally, the method for synthesizing electrode materials for better electrochemical performance is discussed.

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“…Using only biological materials, biomimetic composite materials with multiple functions can be manufactured. For example, Jiao et al developed a double-phase biomimetic procallus with gelatin-reduced graphene oxide (GOG) and photo-crosslinked gelatin hydrogel, which provide hypoxic microenvironment and mediated bidirectional differentiation of BMSCs to osteogenesis and angiogenesis, thereby promoting the regeneration of bone defects [ 94 ]. Therefore, a new generation of scaffold-based MSC culture techniques should not only simulate stem cell niches from multiple aspects simultaneously, provide as many stem cell niche components as possible, but also release bioactive molecules to target effector cells and activate "self-repair" mechanisms at damaged sites.…”

Section: Physiological Microenvironment Simulation Pre-activationmentioning

confidence: 99%

Potential pre-activation strategies for improving therapeutic efficacy of mesenchymal stem cells: current status and future prospects

Jiang²,

Hou

et al. 2022

Stem Cell Res Ther

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Mesenchymal stem cell (MSC)-based therapy has been considered as a promising approach targeting a variety of intractable diseases due to remarkable multiple effect of MSCs, such as multilineage differentiation, immunomodulatory property, and pro-regenerative capacity. However, poor engraftment, low survival rate of transplanted MSC, and impaired donor-MSC potency under host age/disease result in unsatisfactory therapeutic outcomes. Enhancement strategies, including genetic manipulation, pre-activation, and modification of culture method, have been investigated to generate highly functional MSC, and approaches for MSC pre-activation are highlighted. In this review, we summarized the current approaches of MSC pre-activation and further classified, analysed the scientific principles and main characteristics of these manipulations, and described the pros and cons of individual pre-activation strategies. We also discuss the specialized tactics to solve the challenges in this promising field so that it improves MSC therapeutic functions to serve patients better.

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Bidirectional differentiation of BMSCs induced by a biomimetic procallus based on a gelatin-reduced graphene oxide reinforced hydrogel for rapid bone regeneration

Cited by 47 publications

References 71 publications

Modulation of immune-inflammatory responses through surface modifications of biomaterials to promote bone healing and regeneration

Modulation of immune-inflammatory responses through surface modifications of biomaterials to promote bone healing and regeneration

Recent Advances in Graphene and Conductive Polymer Composites for Supercapacitor Electrodes: A Review

Potential pre-activation strategies for improving therapeutic efficacy of mesenchymal stem cells: current status and future prospects

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