Bidirectional Association Between Depression and Sexual Dysfunction: A Systematic Review and Meta-Analysis

Atlantis, Evan; Sullivan, Thomas

doi:10.1111/j.1743-6109.2012.02709.x

Cited by 302 publications

(177 citation statements)

References 35 publications

(90 reference statements)

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“…In the general population, SD and depression are considered to be associated with each other due to a known bidirectional interdependence between depression and SD [12,23]. In female MS patients, previous studies also suggest an interdependence of SD, depression, disease severity, and duration [12,13,24].…”

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confidence: 92%

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Sexual Dysfunction Seems to Trigger Depression in Female Multiple Sclerosis Patients

et al. 2018

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Background: In women with multiple sclerosis (MS), depression and sexual dysfunction (SD) are common. Whether SD promotes depression or vice versa remains unclear despite therapeutic relevance. Therefore, we aimed to assess whether SD more likely triggers depression or vice versa. Methods: In 83 female MS patients and 21 age-matched healthy women, we assessed depression, using the Beck Depression Inventory-V (BDI-V), and SD using the Female Sexual Function Index (FSFI). We diagnosed depression with BDI-V-scores >35 and SD with FSFI scores < 26.55. We divided patients into groups with and without SD, with and without depression. Between groups, we compared prevalence of SD and depression (Fisher’s-exact-test), age, MS-duration, MS-severity, BDI-V-, and FSFI scores (Mann-Whitney U-test; significance: p < 0.05). Results: A total of 37/83 MS patients and 1/21 controls had SD; 28/83 patients and 3/21 controls had depression; 51.4% patients with SD but only 19.6% without SD had depression (p = 0.003). SD was present in 67.9% depressed and 32.7% non-depressed patients. BDI-V-scores were higher in patients with SD than in patients without SD. FSFI scores were lower in depressed than non-depressed patients. Conclusion: In conclusion, SD was more common than depression. SD afflicted 67.9% depressed MS patients and was also more common in non-depressed MS patients than controls. SD may occur independently from depression while increased depressiveness seems linked to coexistent SD.

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confidence: 92%

“…We, therefore, evaluated whether there is evidence supporting the hypothesis that SD in female MS patients may cause depression or whether SD and depression are simply associated with each other due to a bidirectional interdependence between depression and SD [23,25,27]. Table 1.…”

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confidence: 99%

Sexual Dysfunction Seems to Trigger Depression in Female Multiple Sclerosis Patients

et al. 2018

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“…However, there is a dearth of research in which, beyond the mere establishment of associations, the relative weight of such factors in the prediction of men's sexual problems is evaluated. For example, the social and psychological challenges that come with aging, including those related to more general deteriorating health or to specific health problems -of oneself and/or of one's partner -as well as reduced independence and mobility, may result in or exacerbate already existing stress, depression, or loneliness, factors that all have been associated with sexual problems in men (Atlantis & Sullivan, 2012;Latini et al, 2006;Martin et al, 2012). Also, sexual dysfunctions in men are not uncommonly associated with problems with sexual function of their partner (Heiman et al, 2007;Jiann et al, 2013).…”

Section: Aging Men's Sexual Problemsmentioning

confidence: 99%

Sexuality in Older Adults (65+)—An Overview of the Literature, Part 1: Sexual Function and its Difficulties

Træen

Hald

Graham

et al. 2016

International Journal of Sexual Health

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Aim: The aim of the current paper was to provide an overview of literature on sexual function and sexual difficulties in older adults. Method:We conducted a narrative review of papers published in English between January 2005 and July 2015 based on an extensive search in PsycINFO. Results:The review showed that while common biological changes may adversely affect sexual function in old age, sexual experience seems to also be affected by psychological and interpersonal factors. Conclusions:Greater life expectancy and better medical care will result in older individuals with chronic diseases living longer. The need for help to cope with changes in sexual health is likely to increase in older adults, as sexuality may be negatively affected through several pathways.

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“…Conversely, depressed patients should be screened for sexual dysfunction 49 . A longitudinal study found the prevalence of sexual problems in depressed individuals to be approximately twice the prevalence in controls (50% vs. 24%) 50 .…”

Section: Influence Of Depression On Sexualitymentioning

confidence: 99%

The impact of severe mental disorders and psychotropic medications on sexual health and its implications for clinical management

2018

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Sexual dysfunction often accompanies severe psychiatric illness and can be due to both the mental disorder itself and the use of psychotropic treatments. Many sexual symptoms resolve as the mental state improves, but treatment-related sexual adverse events tend to persist over time, and are unfortunately under-recognized by clinicians and scarcely investigated in clinical trials. Treatment-emergent sexual dysfunction adversely affects quality of life and may contribute to reduce treatment adherence. There are important differences between the various compounds in the incidence of adverse sexual effects, associated with differences in mechanisms of action. Antidepressants with a predominantly serotonergic activity, antipsychotics likely to induce hyperprolactinaemia, and mood stabilizers with hormonal effects are often linked to moderate or severe sexual dysfunction, including decreased libido, delayed orgasm, anorgasmia, and sexual arousal difficulties. Severe mental disorders can interfere with sexual function and satisfaction, while patients wish to preserve a previously satisfactory sexual activity. In many patients, a lack of intimate relationships and chronic deterioration in mental and physical health can be accompanied by either a poor sexual life or a more frequent risky sexual behaviour than in the general population. Here we describe the influence of psychosis and antipsychotic medications, of depression and antidepressant drugs, and of bipolar disorder and mood stabilizers on sexual health, and the optimal management of patients with severe psychiatric illness and sexual dysfunction.

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Bidirectional Association Between Depression and Sexual Dysfunction: A Systematic Review and Meta-Analysis

Cited by 302 publications

References 35 publications

Sexual Dysfunction Seems to Trigger Depression in Female Multiple Sclerosis Patients

Sexual Dysfunction Seems to Trigger Depression in Female Multiple Sclerosis Patients

Sexuality in Older Adults (65+)—An Overview of the Literature, Part 1: Sexual Function and its Difficulties

The impact of severe mental disorders and psychotropic medications on sexual health and its implications for clinical management

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