Bicarbonate homeostasis in excitable tissues: role of AE3 Cl−/HCO3− exchanger and carbonic anhydrase XIV interaction

Casey, Joseph R.; Sly, William S.; Shah, Gul N.; Álvarez, Bernardo V.

doi:10.1152/ajpcell.00177.2009

Cited by 44 publications

(60 citation statements)

References 54 publications

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“…The overall structure and fold is quite similar to the CAII with root mean square deviation of 0.4 Å 2 , when C a traces are superimposed. CAVIII have a distinct feature due to the presence of Glu-rich N-terminal region (24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36), that has no counterparts in other CAs. 12 CAVIII cavity has a much narrower opening because of the steric constrain by two bulky residues (Arg116 and Ile224) at the cavity entrance.…”

Section: Three-dimensional Structurementioning

confidence: 99%

“…163,164 Two alternate transcripts of AE3, full-length (AE3 fl) and cardiac (AE3c), are expressed in central nervous system (CNS), associated with the CAII and CAIV, forming a HCO À 3 transport metabolon to maximize HCO À 3 flux across the plasma. 31 CAII coupled to Cl À / HCO À 3 exchanger also acts to load parietal cells with HCl for secretion in stomach. 165 Inorganic SO 2À 4 is abundant anion in the sea and in vertebrate plasma.…”

Section: Ca As a Metabolonmentioning

confidence: 99%

“…Even now researchers are engaged in the area of structure, function drug design for CAs. [31][32][33][34][35][36][37] Several valuable reviews are already available designing activator and inhibitors of CAs. 38,39 Here, we emphasize the application of CA in drug design, drug screen, carbon sensor and carbon capture technology.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Structure, function and applications of carbonic anhydrase isozymes

Hassan

Shajee

Waheed

et al. 2013

Bioorganic & Medicinal Chemistry

Self Cite

212

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Section: Three-dimensional Structurementioning

confidence: 99%

Section: Ca As a Metabolonmentioning

confidence: 99%

See 1 more Smart Citation

Structure, function and applications of carbonic anhydrase isozymes

Hassan

Shajee

Waheed

et al. 2013

Bioorganic & Medicinal Chemistry

Self Cite

212

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“…The CA14 can speed up the removal of CO 2 from the neural retina and regulate the function of photoreceptors. Retinal zinc deficiency influences visual function by affecting the activity of its zinc-containing enzymes (Adijanto et al, 2009;Casey et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Regulation of zinc transporter 3 and carbonic anhydrases 2 and 14 mRNA expression in the retina of rats affected by low dietary zinc

Zhang¹,

Xiao²,

Liu³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. We looked at how zinc transporter 3 ZnT-3) mRNA expression in the rat retina is affected by low dietary zinc. Groups of 12 four-week-old male Sprague Dawley rats were fed on a low-zinc diet for 2, 4 or 6 weeks. Half of each group was then fed with a normal-zinc content diet and the other half was given a low-zinc content diet. The expression of ZnT-3, carbonic anhydrase 2 (CA2) and 14 (CA14) were detected by RT-PCR. After the rats were fed a low-zinc content diet for 2 weeks, their retina CA2 and CA14 mRNA levels were decreased, and the ZnT-3 mRNA was increased compared with the control rats. After they were fed a low-zinc diet for 4 weeks, ZnT-3, CA2 and CA14 mRNA levels decreased significantly. Then, after being changed back to a normal diet for 2 weeks, the rats had ZnT-3, CA2 and CA14 mRNA levels recovery in the retina.

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“…Retinal cells express HCO 3 - transporters and carbonic anhydrases [126, 127]. Krebs cycle-derived HCO 3 - activates mitochondrial sAC, which is a critical metabolic sensor and modulates oxidative phosphorylation [48, 128].…”

Section: Role Of Sac In Health and Diseasementioning

confidence: 99%

Soluble adenylyl cyclase in health and disease

Schmid

Meili

Salathé

2014

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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The second messenger cAMP is integral for many physiological processes. Soluble adenylyl cyclase (sAC) was recently identified as a widely expressed intracellular source of cAMP in mammalian cells. sAC is evolutionary, structurally, and biochemically distinct from the G-protein-responsive transmembranous adenylyl cyclases (tmAC). The structure of the catalytic unit of sAC is similar to tmAC, but sAC does not contain transmembranous domains, allowing localizations independent of the membranous compartment. sAC activity is stimulated by HCO3-, Ca2+ and is sensitive to physiologically relevant ATP fluctuations. sAC functions as a physiological sensor for carbon dioxide and bicarbonate, and therefore indirectly for pH. Here we review the physiological role of sAC in different human tissues with a major focus on the lung.

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Bicarbonate homeostasis in excitable tissues: role of AE3 Cl⁻/HCO₃⁻ exchanger and carbonic anhydrase XIV interaction

Abstract: Casey JR, Sly WS, Shah GN, Alvarez BV. Bicarbonate homeostasis in excitable tissues: role of AE3 Cl Ϫ /HCO 3 Ϫ exchanger and carbonic anhydrase XIV interaction.

Cited by 44 publications

References 54 publications

Structure, function and applications of carbonic anhydrase isozymes

Structure, function and applications of carbonic anhydrase isozymes

Regulation of zinc transporter 3 and carbonic anhydrases 2 and 14 mRNA expression in the retina of rats affected by low dietary zinc

Soluble adenylyl cyclase in health and disease

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