Bibliometric Analysis Reveals a 20-Year Research Trend for Chemotherapy-Induced Peripheral Neuropathy

Abstract

ObjectiveA lot of research has focused on the field of chemotherapy-induced peripheral neuropathy (CIPN). In this study, we performed a bibliometric analysis of CIPN-related publications to identify the key research areas and trends over the last 20 years.MethodsWe searched the Web of Science core collection for publications related to CIPN that were published between January 2001 and September 2021. We then performed bibliometric analysis and visualization using Microsoft Excel 2019, VOSviewer, and the Bibliometric online analysis platform (https://bibliometric.com/).ResultsIn total, we identified 2,188 eligible publications in the field of CIPN, with an increasing trend in the annual number of publications. The United States and Italy were dominant in the CIPN field. Supportive Care in Cancer was the most productive journal. G. Cavaletti and A.A. Argyriou published the largest number of papers. Of all institutions, the University of Milano-Bicocca, Italy, published the highest number of papers. Analysis of the co-occurrence of keywords revealed the specific characteristics relating to the four main clusters: oxaliplatin, paclitaxel, pain management, and quality of life (QOL). Newly emerging research focusses predominantly on neuroinflammatory mechanisms and non-pharmacological interventions for CIPN.ConclusionThis bibliometric study reviewed the evolutionary trends in CIPN research and identified current research hotspots and research trends. In addition, we identified journals, institutions, and authors, with the highest levels of impact to enhance the collaboration and learning.

Chemotherapy-induced peripheral neuropathy in children and adolescent cancer patients

“…This dearth of high-quality and consistent evidence was also noted in recent clinical practice guidelines, which-as noted above-only support duloxetine as moderately effective for treatment of existing CIPN (Hershman et al, 2014). More recently, Gu et al reported a 20-year bibliometric analysis highlighting the rise in efforts to study non-pharmacological interventions for CIPN reaching a high point in only the last few years (Gu et al, 2022). Of note, some of the key potential mechanisms underpinning CIPN, including inflammation, may be influenced by exercise, providing a possible mechanistic link (Chung et al, 2022).…”

Incidence, risk factors, prevention and treatment of postmastectomy pain syndrome in breast cancer: A multicenter study

“…Chemotherapeutic agents such as taxanes, platinum drugs and Changchun ower alkaloids breast cancer can be neurotoxic [71][72][73]. A study reported that three months after taxane treatment, breast cancer survivors still had chemotherapy-induced peripheral neuropathy [74].…”

A mechanistic understanding of the relationship between skin innervation and chemotherapy-induced neuropathic pain

“…It has been suggested that separate anatomical pathways exist for these respective components ( 26 , 43 ), the so-called lateral and medial pain system ( 44 ). A schematic presentation of the medial and lateral and medial pain ascending pathways in chemotherapy-induced peripheral neurotoxicity is reported in Figure 2 (evidence is presented in the following citations: 34 , 39 , 43 – 50 ). Since non-peptidergic fibers are overrepresented in the epidermis, and since the degeneration of these fibers seems to be associated with the affective component of neuropathic pain, it is recommended to use a numerical rating scale (NRS) for pain unpleasantness in addition to an NRS for pain intensity for patients with CIPN-associated neuropathic pain.…”