Bibliometric analysis of research on Alzheimer’s disease and non-coding RNAs: Opportunities and challenges

Fei, Xinxing; Wang, Shiqi; Li, Jiyang; Zeng, Qiu; Gao, Ya-Qian; Hu, Yue

doi:10.3389/fnagi.2022.1037068

Cited by 9 publications

(8 citation statements)

References 55 publications

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“…Our study aimed to collect articles related to mitochondrial dysfunction in AD and analyzed them quantitatively and qualitatively, which no one has done yet. Meanwhile, we searched articles from the Web of Science core collection database so the extracted data are reliable, comprehensive, and highly recognized ( Fei et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Trends of mitochondrial changes in AD: a bibliometric study

Song

Guo

et al. 2023

Front. Aging Neurosci.

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BackgroundAlzheimer’s disease (AD) is a neurodegenerative disease characterized by progressive progress and memory loss, which eventually develops into dementia. It can cause personality disorders and decreased quality of life of patients. Currently, AD patients account for 60–70% of global dementia patients and the incidence rate of AD is increasing annually. AD not only causes pain to patients but also brings a heavy burden to the entire family. Studies have found that there is a connection between mitochondrial dysfunction and other biochemical changes in AD like classical neuropathological hallmarks (β-amyloid and tau protein), inflammation pathways, oxidative stress, and so on. Evidence shows that early treatment targeted directly to mitochondria could extend the lifespan of model mice and decrease the relevant neuropathological markers. Therefore, research on the mitochondrial dysfunction of AD can be of potential significance for clinical treatment. To date, few bibliometric analysis articles related to mitochondrial dysfunction of AD have been published. Bibliometric analysis refers to quantitatively analyzing certain aspects of articles like publishers, authors, and countries by using statistical and mathematical methods. Combined with statistical software, a large number of papers can be converted to visualization figures and tables, which provide vital information such as keyword hotspots and the names of contributing authors. Through the bibliometric analysis method, our study aimed to provide study trends and keyword hotpots for researchers to conduct further relevant research in this field.MethodsWe used the Web of Science core collection database as a literature retrieval tool to obtain data related to mitochondrial changes in Alzheimer’s disease during the last 20 years. The retrieval type was [TS = (Alzheimer’s disease)] ND [TS = (mitochondrion)], ranging from January 1, 2000 to June 30, 2022. VOSviewer v1.6.18, Arcgis 10.8, and HistCite pro 2.1 were used to conduct data visualization analysis. VOSviewer v1.6.18 made relevant network visualization maps of the cooperative relationship between relevant countries, institutions, and authors (co-authorship), the frequency of different keywords appearing together (co-occurrence), and the frequency of different articles cited together (co-cited). Arcgis 10.8 created the world map of publications distribution in this field and Histcite pro 2.1 was used to count the local citation score (LCS) of references. In addition, Journal Citation Reports were used to consult the latest journal import factor and JCI quartile.ResultsAs of June 30, 2022, from the Web of Science core collection, we selected 2,474 original articles in English, excluding the document types of the news items, meeting abstracts, and some articles that had little relevance to our theme. The United States acted as the leader and enjoyed a high reputation in this field. The University of California System was the institution that made the greatest contribution (3.64% with 90 papers). Most articles were published in the Journal of Alzheimer’s Disease (8.21%, with 203 papers). The most frequently co-cited journal in Q1 was the Journal of Biological Chemistry (8,666 citations, TLS: 1039591). Russel H. Swerdlow (55 publications) was the most productive author and PH Reddy was the most co-cited author with 1,264 citations (TLS: 62971). The hotpots of mitochondrial dysfunction in AD were as follows: “oxidative stress,” “amyloid-beta-protein,” “tau,” “apoptosis,” “inflammation,” “autophagy,” “precursor protein,” “endoplasmic-reticulum,” “dynamics” and “mitochondrial unfolded protein response.”ConclusionThis bibliometric analysis research will help readers rapidly identify current hotpots and milestone studies related to directions of interest in AD research.

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Section: Discussionmentioning

confidence: 99%

Trends of mitochondrial changes in AD: a bibliometric study

Song

Guo

et al. 2023

Front. Aging Neurosci.

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“…21 To date, bibliometrics has been applied in orthopedics, rehabilitation, psychiatry, endocrinology, and many other fields. [22][23][24] However, there is still a lack of bibliometric analysis in the field of TCE and OA. Therefore, we conducted a bibliometric analysis of relevant literature in the field of TCE and OA in the past 20 years (2003-2022) via Bibliometrix and CiteSpace, aiming to explore the research status, hotspots, and future development trends and to provide references for further research in this field.…”

Section: Introductionmentioning

confidence: 99%

Bibliometric Analysis of Research on Traditional Chinese Exercise and Osteoarthritis

Zeng,

Liu,

et al. 2024

JPR

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Background: Osteoarthritis (OA) is a common disease in geriatric rehabilitation medicine caused by the progressive destruction of articular cartilage. Traditional Chinese exercise (TCE) is an important component of traditional sports in China and aims to stretch the musculoskeletal tract and relieve joint pain. Bibliometrics can help researchers find suitable partners and understand the research hotspots and trends in a certain field. However, there is still a lack of bibliometric analysis in the field of TCE and OA. Methods: All the literature was obtained from the Web of Science Core Collection database. The last search was performed on July 28, 2023. The bibliometric indicators, such as publications, citations, and H-index, were recorded. Bibliometrix and CiteSpace were used for visualization analysis. In addition, randomized controlled trials were included to summarize the exercise prescription of TCE for OA. Results: A total of 170 articles were included. The field of OA with TCE had great development potential and was in the rising period. The countries, institutions, and authors with the most publications were the United States, Tufts Medical Center, and Harvey WF, respectively. The most popular journal was Osteoarthritis and Cartilage. The recent burst keywords in this field were mainly "hip", "pilot", and "risk". Tai Chi was the most studied TCE with the most detailed content of exercise prescription, followed by Baduanjin and Wuqinxi. Conclusion:Our study provides a basis for researchers in this field to choose appropriate partner and academic journals. Moreover, pain, muscle strength, and quality of life management of elderly OA patients are research hotspots in this field. The intervention of hip OA risk through TCE is expected to become a research direction for emerging teams. The TCE prescription we summarized can better provide researchers with more treatment details.

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“…Presently, the utilization of the Science Citation Index Expanded or Social Science Citation Index has become indispensable in gauging the research achievements of countries, institutions, and authors across multiple dimensions ( Jallow et al, 2021 ). Recent times have witnessed the execution of bibliometric analyses within the Web of Science (WoS) categories, including psychology ( Berta et al, 2022 ), neurosciences ( Wilson et al, 2021 ; Fei et al, 2022 ), cardiology ( Wang et al, 2022 ), and cancer ( Fresno-Alba et al, 2023 ; Xu et al, 2023 ). These analyses have played a crucial role in evaluating research achievements and productivity across countries, institutions, and authors.…”

Section: Introductionmentioning

confidence: 99%

A comprehensive bibliometric analysis of global research on the role of acrolein in Alzheimer’s disease pathogenesis: involvement of amyloid-beta

Jallow,

Nguyen,

Sanotra

et al. 2024

Front. Aging Neurosci.

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BackgroundAlzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive and behavioral decline. Acrolein, an environmental pollutant and endogenous compound, is implicated in AD development. This research employs bibliometric analysis to assess current trends and key areas concerning acrolein-AD interaction.MethodsThe Web of Science was used to extensively review literature on acrolein and AD. Relevant data were systematically gathered and analyzed using VOSviewer, CiteSpace, and an online bibliometric tool.ResultsWe identified 120 English publications in this specialized field across 19 journals. The Journal of Alzheimer’s Disease was the most prominent. The primary contributors, both in terms of scientific output and influence, were the USA, the University of Kentucky, and Ramassamy C, representing countries/regions, institutions, and authors, respectively. In this field, the primary focus was on thoroughly studying acrolein, its roles, and its mechanisms in AD utilizing both in vivo and in vitro approaches. A significant portion of the research was based on proteomics, revealing complex molecular processes. The main focuses in the field were “oxidative stress,” “lipid peroxidation,” “amyloid-beta,” and “cognitive impairment.” Anticipated future research trajectories focus on the involvement of the internalization pathway, covering key areas such as synaptic dysfunction, metabolism, mechanisms, associations, neuroinflammation, inhibitors, tau phosphorylation, acrolein toxicity, brain infarction, antioxidants, chemistry, drug delivery, and dementia. Our analysis also supported our previous hypothesis that acrolein can interact with amyloid-beta to form a protein adduct leading to AD-like pathology and altering natural immune responses.ConclusionThis study provides a broad and all-encompassing view of the topic, offering valuable insights and guidance to fellow researchers. These emerging directions underscore the continuous exploration of the complexities associated with AD. The analyses and findings aim to enhance our understanding of the intricate relationship between acrolein and AD for future research.

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Bibliometric analysis of research on Alzheimer’s disease and non-coding RNAs: Opportunities and challenges

Cited by 9 publications

References 55 publications

Trends of mitochondrial changes in AD: a bibliometric study

Trends of mitochondrial changes in AD: a bibliometric study

Bibliometric Analysis of Research on Traditional Chinese Exercise and Osteoarthritis

A comprehensive bibliometric analysis of global research on the role of acrolein in Alzheimer’s disease pathogenesis: involvement of amyloid-beta

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