Beyond TPH: Health-Based Evaluation of Petroleum Hydrocarbon Exposures

Hutcheson, Michael S.; Pedersen, Dana C.; Anastas, Nicholas D.; Fitzgerald, John J.; Silverman, Diane

doi:10.1006/rtph.1996.0066

Cited by 44 publications

(40 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fractionated assessments assume that the toxicity of a chemically defined portion (fraction) of the whole mixture can be determined by the toxicity of a surrogate. When the surrogate is the most toxic compound within the fraction, the entire fraction is assumed to have the greatest potential toxicity (Hutcheson et a., 1996). These procedures are in use for total 28 petroleum hydrocarbon (TPH) contamination and have been proposed for PAHs to account for the nongenotoxic congeners (Brown et al, 1999).…”

Section: Fraction Surrogate Proceduresmentioning

confidence: 99%

“…In all three, cancer risk is determined first by evaluating site exposure levels of common carcinogens present in TPH including benzene and specific PAHs (U.S. EPA, 2002d); use of the indicator compound approach for carcinogenic risk is expected to account for the most toxic compounds and be protective of human health (Hutcheson et al, 1996). Each procedure has utilized the RfD derivation process to determine noncancer risk values for each of the fractions based on toxicity information for surrogate components within the fractions (U.S. EPA, 2002d).…”

Section: Fraction Surrogate Proceduresmentioning

confidence: 99%

“…TPH contamination is widespread; contamination consisting of only TPH accounted for 50% of Massachusetts' hazardous waste sites prior to the development of their fraction approach (Hutcheson et al, 1996). Yet TPH is not one entity suitable for whole mixtures toxicity testing.…”

Section: Fraction Surrogate Proceduresmentioning

confidence: 99%

“…Yet TPH is not one entity suitable for whole mixtures toxicity testing. This mixture consists of hundreds of aliphatic and aromatic hydrocarbons that differ depending on the product (e.g., gasoline, diesel) which was released into the environment, the crude from which the product was refined and the transformation processes in the environment during weathering (Hutcheson et al, 1996; U.S.…”

Section: Fraction Surrogate Proceduresmentioning

confidence: 99%

“…Component based dose or response addition is not suitable for a TPH site due to the analytical and calculation workload necessary to attempt adding toxicity for hundreds of chemicals, many of which do not have sufficient health effects data (Hutcheson et al, 1996).…”

Section: Fraction Surrogate Proceduresmentioning

confidence: 99%

See 4 more Smart Citations

The Toxicology of Chemical Mixtures Risk Assessment for Human and Ecological Receptors

Sterner¹,

Robinson²,

Mattie³

et al. 2005

View full text Add to dashboard Cite

REPORT DOCUMENTATION PAGE ublic reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the lata needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing ,is burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently alid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. REPORT DATE (DD-MM-YYYY)2 I. SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR'S ACRONYM(S)kir Force Materiel Command*** HEPB SUPPLEMENTARY NOTES ABSTRACT4ixtures of chemicals represent a concern in all areas of toxicology and a challenge to risk Issessors as most sites with environmental contamination, including Department of Defense sites, involve simultaneous or sequential exposures of multiple chemicals to human or ýcological receptors.A major concern with mixtures is that they may lead to outcomes (health effects) or increased toxicity (synergism) not expected from the risk 'haracterization of individual chemicals at the site.The focus of this literature review is :o examine the principles used to determine toxicity in chemical mixtures risk assessment for luman and ecological receptors at hazardous waste sites.This review provides an overview of 'urrent practices useful to a remedial project manager or risk assessor prior to their first ",hemical mixtures risk assessment. 5.SUBJECTTERMS

show abstract

Section: Fraction Surrogate Proceduresmentioning

confidence: 99%

Section: Fraction Surrogate Proceduresmentioning

confidence: 99%

Section: Fraction Surrogate Proceduresmentioning

confidence: 99%

Section: Fraction Surrogate Proceduresmentioning

confidence: 99%

Section: Fraction Surrogate Proceduresmentioning

confidence: 99%

See 3 more Smart Citations

The Toxicology of Chemical Mixtures Risk Assessment for Human and Ecological Receptors

Sterner¹,

Robinson²,

Mattie³

et al. 2005

View full text Add to dashboard Cite

show abstract

Total Petroleum Hydrocarbons

Speight¹

2005

Environmental Analysis and Technology for the Refining Industry

View full text Add to dashboard Cite

Assessment and Monitoring of Soil Degradation during Land Use Change Using Multivariate Analysis

et al. 2016

View full text Add to dashboard Cite

Not only are soil erosion and overall loss of soil fertility serious issues for loess‐derived soils of developing nations, such as Iran, but they are also global problems. This research investigated the role of land use change and its effect on soil degradation in cultivated, pasture, and urban lands, when compared with native forest in terms of declining of soil quality and fertility. Multivariate statistical methods including principal component analysis and cluster analysis were employed to determine the relative magnitude of anthropogenic and natural influences on soil quality. Partial least squares (PLS), principal component regression, and ordinary least squares regression were used to predict soil cation exchange capacity using soil characteristics. Principal component analysis identified five primary components of soil quality. PC1 explained 41·01% of the total variance, PC2 accounted for 15·29%, and PC3 accounted for 11·3%. PC4 and PC5 accounted for 7·37% and 4·19% of the total variance, respectively. Cluster analysis revealed that the lowest soil quality occurred in urban soils. An exponential semivariogram using PLS predictions revealed stronger spatial dependence among cation exchange capacity [r2 = 0·80, root mean square error (RMSE) = 1·99] than the other methods, principal component regression [r2 = 0·84, RMSE = 2·45] and ordinary least squares [r2 = 0·84, RMSE = 2·45]. Therefore, the PLS method provided the best model for the data. In stepwise regression analysis, mean weight diameter and labile carbon were selected as influential variables in all soils. This study quantified reductions in numerous soil quality parameters resulting from extensive land‐use changes and urbanization in the Ziarat watershed in northern Iran. Copyright © 2016 John Wiley & Sons, Ltd.

show abstract

Beyond TPH: Health-Based Evaluation of Petroleum Hydrocarbon Exposures

Cited by 44 publications

References 0 publications

The Toxicology of Chemical Mixtures Risk Assessment for Human and Ecological Receptors

The Toxicology of Chemical Mixtures Risk Assessment for Human and Ecological Receptors

Total Petroleum Hydrocarbons

Assessment and Monitoring of Soil Degradation during Land Use Change Using Multivariate Analysis

Contact Info

Product

Resources

About