Beyond the "Spine of Hydration": Chiral SFG Spectroscopy Detects DNA First Hydration Shell and Base Pair Structures
Ethan Perets,
Daniel Konstantinovsky,
Ty Santiago
et al.
Abstract:Experimental methods capable of selectively probing water at the DNA minor groove, major groove, and phosphate backbone are crucial for understanding how hydration influences DNA structure and function. Chiral-selective sum frequency generation spectroscopy (chiral SFG) is unique among vibrational spectroscopies because it can selectively probe water molecules that form chiral hydration structures around biomolecules. However, interpreting chiral SFG spectra is challenging since both water and the biomolecule … Show more
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