Journal of Cell Biology volume 214, issue 6, P641-643 2016 DOI: 10.1083/jcb.201608060 View full text
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Mugdha Deshpande, Avital A. Rodal

Abstract: Early infantile epileptic encephalopathy (EIEE)–associated mutations in MUNC18-1 cause Munc18-1 misfolding and cellular aggregation. In this issue, Chai et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201512016) find that Munc18-1 is a molecular chaperone for α-synuclein and that aggregated Munc18-1 EIEE-causing mutants promote α-synuclein aggregation.