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Cited by 49 publications
(28 citation statements)
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“…Although the mechanisms underlying the TBA effect on NLRP3 activation are not clearly understood, our findings suggest that Prx may be a potential target. The Prx family, comprising Prx1, 2, 3, 4, 5, and 6, belongs to the redox regulatory proteins, which maintain the intracellular reducing milieu (Detienne et al, 2018). Prx1 and Prx2 are specific targets of HDAC6 (Parmigiani et al, 2008), and once deacetylated, Prx1 and Prx2 lose their antioxidant capacity, resulting in free radical accumulation.…”
Section: Discussionmentioning
confidence: 99%
“…Although the mechanisms underlying the TBA effect on NLRP3 activation are not clearly understood, our findings suggest that Prx may be a potential target. The Prx family, comprising Prx1, 2, 3, 4, 5, and 6, belongs to the redox regulatory proteins, which maintain the intracellular reducing milieu (Detienne et al, 2018). Prx1 and Prx2 are specific targets of HDAC6 (Parmigiani et al, 2008), and once deacetylated, Prx1 and Prx2 lose their antioxidant capacity, resulting in free radical accumulation.…”
Section: Discussionmentioning
confidence: 99%
“…Peroxiredoxins (Prx) are enzymes capable of reducing the peroxide functions of several molecules, including hydrogen peroxide and peroxynitrite. In humans, six different isoforms of Prx can be distinguished, with different subcellular locations [13] (Figure 2). At the cardiac level, peroxiredoxin 2 and 4 have been identified by proteomic analysis to be involved in cardiomyopathy and heart failure [14][15][16].…”
Section: Peroxiredoxinsmentioning
confidence: 99%
“…In particular, the extract blunted the alteration of protein level induced by LPS, thus restoring the physiological condition observed in the vehicle-treated group. Of note are the pro-homeostatic effect on the levels of peroxiredoxin-2 (PRDX2), glutathione reductase (GSHR), catalase (CATA), and superoxide dismutase (SODC), which are deeply involved in contrasting oxidative stress-induced organ injury [40,41]. In addition, the water extract of H. procumbens normalized the levels of specific proteins, namely, drebrin-like protein (DBNL), macrophage-capping protein (CAPG), prothymosin alpha (PTMA), and high mobility group protein B2 (HGMB2), which are involved in the anti-proliferative effect, T-cell regulation, and defense against opportunistic infections [42][43][44][45].…”
Section: Resultsmentioning
confidence: 99%