2015
DOI: 10.1002/med.21353
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Abstract: Betulinic acid (BA) is a lupane-type pentacyclic triterpene, distributed ubiquitously throughout the plant kingdom. BA and its derivatives demonstrate multiple bioactivities, particularly an antitumor effect. This review critically describes the recent research on isolation, synthesis, and derivatization of BA and its natural analogs betulin and 23-hydroxybetulinic acid. The subsequent part of the review focuses on the current knowledge of antitumor properties, combination treatments, and pharmacological mecha… Show more

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Cited by 156 publications
(94 citation statements)
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References 127 publications
(295 reference statements)
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“…BA administration to mice fed high fat diets decreases plasma glucose levels, increases insulin levels, protects against hepatocellular steatosis, ameliorates hyperglycaemia and dyslipidaemia, prevents abdominal fat accumulation and decreases body weight 33 . Finally, it is well known the cytotoxic activity of BA to over 20 cancer cell lines probably triggers apoptosis 34 . Importantly, BA is much more cytotoxic to cancer cells than to normal cells, such as skin fibroblasts, peripheral blood lymphocytes and melanocytes 34 .…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…BA administration to mice fed high fat diets decreases plasma glucose levels, increases insulin levels, protects against hepatocellular steatosis, ameliorates hyperglycaemia and dyslipidaemia, prevents abdominal fat accumulation and decreases body weight 33 . Finally, it is well known the cytotoxic activity of BA to over 20 cancer cell lines probably triggers apoptosis 34 . Importantly, BA is much more cytotoxic to cancer cells than to normal cells, such as skin fibroblasts, peripheral blood lymphocytes and melanocytes 34 .…”
Section: Resultsmentioning
confidence: 99%
“…Finally, it is well known the cytotoxic activity of BA to over 20 cancer cell lines probably triggers apoptosis 34 . Importantly, BA is much more cytotoxic to cancer cells than to normal cells, such as skin fibroblasts, peripheral blood lymphocytes and melanocytes 34 . This evidence together confirms that the natural compound BA may be a promising therapeutic agent in the treatment of different pathologies.…”
Section: Resultsmentioning
confidence: 99%
“…To enhance the benefits and minimize the side effects of this treatment, several novel derivatives have been synthesized. Multiple studies have demonstrated that the antitumour mechanisms of BA, 23-HBA and their derivatives may be related to the mitochondria and ROS [2630]. However, the underlying mechanisms are unclear, and the source of ROS is still unknown.…”
Section: Introductionmentioning
confidence: 99%
“…Betulinic acid has anti-malarial, anti-HIV and anti-inflammatory activities (41). BetA has also been found to have anticancer activities in various cancers through inducing apoptosis and inhibition of cell proliferation in several cancers, including pancreatic cancer, prostate cancer, leukemia and melanoma (42)(43)(44)(45)(46)(47). BetA could regulate the expression or post-translational modification of lamin B1, Sp1, NF-κB and result in cell proliferation inhibition and apoptosis (46)(47)(48).…”
Section: Introductionmentioning
confidence: 99%