Betaxolol and Timolol

A Review of Ocular and Systemic Complications in Glaucoma Pharmacotherapy

“…Notably, several undesirable ocular effects are shared across different drug classes. Discomfort upon instillation, including symptoms such as stinging, burning, itching, tearing, and blurred vision, are frequently reported with all classes of glaucoma medications [10,16,[60][61][62][63][64][65][66][76][77][78]83,[89][90][91][92][93][94][95][96][97][98]. Additionally, ocular allergic reactions, which may necessitate discontinuation in severe cases, commonly present as allergic conjunctivitis, granulomatous papillary conjunctivitis, or punctate keratopathy.…”

“…Rarely: hyperemia, corneal decompensation, and contact dermatitis Oral: Symptom complex (47.8%): general malaise, weight loss, fatigue, nausea, anorexia, depression and loss of libido [130]. Organs involved: gastrointestinal, neurological, and hematological Topical: transient bitter or metallic taste (25%) [16,54,55,139]; Rarely: nausea, fatigue, headache, skin rashes, paresthesia, and urolithiasis Βeta (β) blockers -Burning or stinging sensation on instillation (~30-40% of patients), eye pain or discomfort, foreign body sensation, itchiness, and blurred vision (due to membrane stabilization property & formulation) [10,[60][61][62][63][64][65][66].…”

“…Subjective side effects may include burning or stinging sensation on instillation (in up to 30-40% of patients), eye pain or discomfort, foreign body sensation, itchiness, and blurred vision [10,[60][61][62][63][64][65][66].…”

A Review of Ocular and Systemic Complications in Glaucoma Pharmacotherapy

“…Notably, several undesirable ocular effects are shared across different drug classes. Discomfort upon instillation, including symptoms such as stinging, burning, itching, tearing, and blurred vision, are frequently reported with all classes of glaucoma medications [10,16,[60][61][62][63][64][65][66][76][77][78]83,[89][90][91][92][93][94][95][96][97][98]. Additionally, ocular allergic reactions, which may necessitate discontinuation in severe cases, commonly present as allergic conjunctivitis, granulomatous papillary conjunctivitis, or punctate keratopathy.…”

“…Rarely: hyperemia, corneal decompensation, and contact dermatitis Oral: Symptom complex (47.8%): general malaise, weight loss, fatigue, nausea, anorexia, depression and loss of libido [130]. Organs involved: gastrointestinal, neurological, and hematological Topical: transient bitter or metallic taste (25%) [16,54,55,139]; Rarely: nausea, fatigue, headache, skin rashes, paresthesia, and urolithiasis Βeta (β) blockers -Burning or stinging sensation on instillation (~30-40% of patients), eye pain or discomfort, foreign body sensation, itchiness, and blurred vision (due to membrane stabilization property & formulation) [10,[60][61][62][63][64][65][66].…”

“…Subjective side effects may include burning or stinging sensation on instillation (in up to 30-40% of patients), eye pain or discomfort, foreign body sensation, itchiness, and blurred vision [10,[60][61][62][63][64][65][66].…”

A Rapid Stability-Indicating RP-HPLC Method for the Determination of Betaxolol Hydrochloride in Pharmaceutical Tablets

“…Betaxolol hydrochloride is a cardioselective betaadrenergic receptor blocking agent used in the treatment of hypertension and glaucoma 1–4. Betaxolol hydrochloride was approved by the US Food and Drug Administration (FDA) for the treatment of hypertension as 10 mg and 20 mg tablets for oral administration.…”

A Review of Ocular and Systemic Complications in Glaucoma Pharmacotherapy

“…Notably, several undesirable ocular effects are shared across different drug classes. Discomfort upon instillation, including symptoms such as stinging, burning, itching, tearing, and blurred vision, are frequently reported with all classes of glaucoma medications [10,16,[60][61][62][63][64][65][66][76][77][78]83,[89][90][91][92][93][94][95][96][97][98]. Additionally, ocular allergic reactions, which may necessitate discontinuation in severe cases, commonly present as allergic conjunctivitis, granulomatous papillary conjunctivitis, or punctate keratopathy.…”

“…Rarely: hyperemia, corneal decompensation, and contact dermatitis Oral: Symptom complex (47.8%): general malaise, weight loss, fatigue, nausea, anorexia, depression and loss of libido [130]. Organs involved: gastrointestinal, neurological, and hematological Topical: transient bitter or metallic taste (25%) [16,54,55,139]; Rarely: nausea, fatigue, headache, skin rashes, paresthesia, and urolithiasis Βeta (β) blockers -Burning or stinging sensation on instillation (~30-40% of patients), eye pain or discomfort, foreign body sensation, itchiness, and blurred vision (due to membrane stabilization property & formulation) [10,[60][61][62][63][64][65][66].…”

“…Subjective side effects may include burning or stinging sensation on instillation (in up to 30-40% of patients), eye pain or discomfort, foreign body sensation, itchiness, and blurred vision [10,[60][61][62][63][64][65][66].…”

A Rapid Stability-Indicating RP-HPLC Method for the Determination of Betaxolol Hydrochloride in Pharmaceutical Tablets

“…Betaxolol hydrochloride is a cardioselective betaadrenergic receptor blocking agent used in the treatment of hypertension and glaucoma 1–4. Betaxolol hydrochloride was approved by the US Food and Drug Administration (FDA) for the treatment of hypertension as 10 mg and 20 mg tablets for oral administration.…”

A Review of Ocular and Systemic Complications in Glaucoma Pharmacotherapy

“…Notably, several undesirable ocular effects are shared across different drug classes. Discomfort upon instillation, including symptoms such as stinging, burning, itching, tearing, and blurred vision, are frequently reported with all classes of glaucoma medications [10,16,[60][61][62][63][64][65][66][76][77][78]83,[89][90][91][92][93][94][95][96][97][98]. Additionally, ocular allergic reactions, which may necessitate discontinuation in severe cases, commonly present as allergic conjunctivitis, granulomatous papillary conjunctivitis, or punctate keratopathy.…”

“…Rarely: hyperemia, corneal decompensation, and contact dermatitis Oral: Symptom complex (47.8%): general malaise, weight loss, fatigue, nausea, anorexia, depression and loss of libido [130]. Organs involved: gastrointestinal, neurological, and hematological Topical: transient bitter or metallic taste (25%) [16,54,55,139]; Rarely: nausea, fatigue, headache, skin rashes, paresthesia, and urolithiasis Βeta (β) blockers -Burning or stinging sensation on instillation (~30-40% of patients), eye pain or discomfort, foreign body sensation, itchiness, and blurred vision (due to membrane stabilization property & formulation) [10,[60][61][62][63][64][65][66].…”

“…Subjective side effects may include burning or stinging sensation on instillation (in up to 30-40% of patients), eye pain or discomfort, foreign body sensation, itchiness, and blurred vision [10,[60][61][62][63][64][65][66].…”

A Rapid Stability-Indicating RP-HPLC Method for the Determination of Betaxolol Hydrochloride in Pharmaceutical Tablets

“…Betaxolol hydrochloride is a cardioselective betaadrenergic receptor blocking agent used in the treatment of hypertension and glaucoma 1–4. Betaxolol hydrochloride was approved by the US Food and Drug Administration (FDA) for the treatment of hypertension as 10 mg and 20 mg tablets for oral administration.…”