Beta-hydroxy beta-methyl butyrate decreases muscle protein degradation <i>via</i> increased Akt/FoxO3a signaling and mitochondrial biogenesis in weanling piglets after lipopolysaccharide challenge

Duan, Yehui; Zheng, Chunyan; Zhong, Yinzhao; Song, Bo; Yan, Zhaoming; Kong, Xiangfeng; Deng, Jinping; Li, Fengna; Yin, Yulong

doi:10.1039/c9fo00769e

Cited by 22 publications

(29 citation statements)

References 45 publications

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“…Thirty healthy pigs (Landrace, 21 ± 2 d, barrow, 5:86 ± 0:18 kg) were chosen and randomly assigned to three groups (n = 10): (1) nonchallenged control (CON); (2) LPS-challenged control (LPS, E. coli serotype 055:B5; Sigma Chemical, St. Louis, MO, USA); (3) LPS +0.60% HMB-Ca treatment (LPS+HMB; HMB-Ca, purity = 99:2%, Ca = 13:6%, Sipu Biochemical Co. LTD, Zhangjiagang, China). The HMB-Ca and LPS doses were used in accordance with our previous studies [12]. On days 1, 3, 5, 7, 9, 11, 13, and 15 of the trial, overnight fasted piglets of the LPS and LPS+HMB groups were intraperitoneally administered LPS, whereas piglets in the CON group were injected with the same volume of sterile saline as previously described [12].…”

Section: Methodsmentioning

confidence: 99%

“…Studies have shown that HMB is used as a nutritional supplement to exert positive roles in animals and humans under stressful or inflammatory conditions [11][12][13]. We recently reported that dietary supplementation with 0.60% HMB prevents muscle protein degradation and alleviates intestinal injury in LPSchallenged piglets [12,13]. Given its beneficial roles under inflammatory condition, we hypothesized that HMB may also exert positive roles in the liver of LPS-challenged piglets.…”

Section: Introductionmentioning

confidence: 99%

“…β-Hydroxy-β-methylbutyrate (HMB) is a derivative of leucine and metabolized in the liver from the keto acid of leucine by α-ketoisocaproate dioxygenase [10]. Studies have shown that HMB is used as a nutritional supplement to exert positive roles in animals and humans under stressful or inflammatory conditions [11][12][13]. We recently reported that dietary supplementation with 0.60% HMB prevents muscle protein degradation and alleviates intestinal injury in LPSchallenged piglets [12,13].…”

Section: Introductionmentioning

confidence: 99%

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Dietary Beta‐Hydroxy Beta‐Methyl Butyrate Supplementation Alleviates Liver Injury in Lipopolysaccharide‐Challenged Piglets

Duan

Song

Zheng

et al. 2021

Oxidative Medicine and Cellular Longevity

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The current study was performed to investigate whether dietary β-hydroxy-β-methylbutyrate (HMB) could regulate liver injury in a lipopolysaccharide- (LPS-) challenged piglet model and to determine the mechanisms involved. Thirty piglets ( 21 ± 2 days old , 5.86 ± 0.18 kg body weight) were randomly divided into the control (a basal diet, saline injection), LPS (a basal diet), or LPS+HMB (a basal diet + 0.60% HMB-Ca) group. After 15 d of treatment with LPS and/or HMB, blood and liver samples were obtained. The results showed that in LPS-injected piglets, HMB supplementation ameliorated liver histomorphological abnormalities induced by LPS challenge. Compared to the control group, the activities of serum aspartate aminotransferase and alkaline phosphatase were increased in the LPS-injected piglets ( P < 0.05 ). The LPS challenge also downregulated the mRNA expression of L-PFK, ACO, L-CPT-1, ICDH β, and AMPKα1/2 and upregulated the mRNA expression of PCNA, caspase 3, TNF-α, TLR4, MyD88, NOD1, and NF-κB p65 ( P < 0.05 ). However, these adverse effects of the LPS challenge were reversed by HMB supplementation ( P < 0.05 ). These results indicate that HMB may exert protective effects against LPS-induced liver injury, and the underlying mechanisms might involve the improvement of hepatic energy metabolism via regulating AMPK signaling pathway and the reduction of liver inflammation via modulating TLR4 and NOD signaling pathways.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Dietary Beta‐Hydroxy Beta‐Methyl Butyrate Supplementation Alleviates Liver Injury in Lipopolysaccharide‐Challenged Piglets

Duan

Song

Zheng

et al. 2021

Oxidative Medicine and Cellular Longevity

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“…Statistical analyses were performed using SPSS Statistics software (version 20, IBM). Figures were prepared using GraphPad Prism 7.0 (GraphPad Software, La Jolla, CA, USA) [50,70,71].…”

Section: Resultsmentioning

confidence: 99%

Baicalin-Copper Complex Modulates Gut Microbiota, Inflammatory Responses, and Hormone Secretion in DON-Challenged Piglets

Zha

Cui

et al. 2020

Animals

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The present experiment assessed the inflammatory responses, hormone secretion, and gut microbiota of weanling piglets administered baicalin-copper complex (BCU) or deoxynivalenol (DON) supplementation diets. Twenty-eight piglets were randomly assigned to four groups: control diet (Con group), a 4 mg DON/kg diet (DON group), a 5 g BCU/kg diet (BCU group), a 5 g BCU + 4 mg DON/kg diet (DBCU group). After 14 days, the results showed that dietary BCU supplementation remarkably increased the relative abundance of Clostrium bornimense and decreased the relative abundance of Lactobacillus in the DBCU group (p < 0.05). BCU decreased the serum concentration of IgG, IL-2, IFN-γ, and IgA in DON treated piglets (p < 0.05), and promoted the serum concentration of IL-1β, IgG, IL-2, IFN-γ, IgA, IL-6, IgM, and TNFα in normal piglets (p < 0.05). BCU increased the concentrations of serum IGF1, insulin, NPY, GLP-1, and GH, and decreased the concentrations of serum somatostatin in no DON treated piglets (p < 0.05). Dietary BCU supplementation significantly promoted the secretion of somatostatin, and inhibited the secretion of leptin in piglets challenged with DON (p < 0.05). BCU regulated the expression of food intake-related genes in the hypothalamus and pituitary of piglets. Collectively, dietary BCU supplementation alleviated inflammatory responses and regulated the secretion of appetite-regulating hormones and growth-axis hormones in DON challenged piglets, which was closely linked to changes of intestinal microbes.

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“…Los factores relacionados con su aparición son la edad, el sexo, consumo insuficiente de proteínas, nivel de actividad física, presencia de enfermedades crónicas, disminución de hormonas sexuales y sedentarismo (14). Conforme el individuo envejece se va presentando una disminución en el número y tamaño de las fibras musculares, ocurriendo una pérdida gradual de la fuerza intrínseca de cada miofibrilla acompañada de un incremento en la infiltración de los ácidos grasos y colágeno, alterándose también la modulación neurológica de la contracción (15,16).…”

Section: Análisis Del Estado Sarcopénico En Individuos Con Enfermedadunclassified

Prevención de la sarcopenia en pacientes con enfermedad de Parkinson: Revisión descriptiva desde la medicina preventiva

2021

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Resumen: La enfermedad de Parkinson ocupa el segundo lugar de las enfermedades neurodegenerativas más comunes en el mundo. La sarcopenia se caracteriza por dinapenia y en los adultos mayores con diagnóstico de enfermedad de Parkinson acelera su progresión. El objetivo de la presente revisión es describir el estado sarcopénico y la importancia de su prevención en los adultos mayores con enfermedad de Parkinson, así como ofrecer una revisión de las medidas de prevención primaria, secundaria y terciaria pertinentes para su abordaje. Si bien el deterioro y la gravedad de la enfermedad de Parkinson se relaciona directamente con el estado sarcopénico del paciente mediante el abordaje disciplinario, la medicina preventiva puede favorecer la calidad de vida de los pacientes mediante medidas de promoción, diagnóstico oportuno, tratamiento farmacológico y no farmacológico y limitación de la progresión de la sarcopenia.Abstract: Parkinson's disease ranks second among the most common neurodegenerative diseases in the world. Sarcopenia is characterized by dynapenia and in older adults diagnosed with Parkinson's disease accelerates its progression. The objective of the present review is to describe the sarcopenic state and the importance of its prevention in older adults with Parkinson's disease, as well as to offer a review of primary prevention measures, secondary and tertiary relevant to its approach. Although the deterioration and severity of Parkinson's disease is directly related to the sarcopenic state of the patient through the disciplinary approach, preventive medicine can favor the quality of life of patients through promotional measures, timely diagnosis, pharmacological treatment and not pharmacological and limiting the progression of sarcopenia.

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Beta-hydroxy beta-methyl butyrate decreases muscle protein degradation via increased Akt/FoxO3a signaling and mitochondrial biogenesis in weanling piglets after lipopolysaccharide challenge

Abstract: The aim of this study was to investigate the effects of dietary β-hydroxy-β-methylbutyrate (HMB) on lipopolysaccharide (LPS)-induced muscle atrophy and to investigate the mechanisms involved.

Cited by 22 publications

References 45 publications

Dietary Beta‐Hydroxy Beta‐Methyl Butyrate Supplementation Alleviates Liver Injury in Lipopolysaccharide‐Challenged Piglets

Dietary Beta‐Hydroxy Beta‐Methyl Butyrate Supplementation Alleviates Liver Injury in Lipopolysaccharide‐Challenged Piglets

Baicalin-Copper Complex Modulates Gut Microbiota, Inflammatory Responses, and Hormone Secretion in DON-Challenged Piglets

Prevención de la sarcopenia en pacientes con enfermedad de Parkinson: Revisión descriptiva desde la medicina preventiva

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