Beta-Hemolytic Streptococcal Infections In Children

Abstract

Bristol Laboratories.demet hyl chl or t et r acycl i ne (Declomycin). Two of these, phenethecillin and demethylchlortetracycline, were then relatively recent additions to the antibiotic field. It was hoped to determine by therapeutic trial whether these two newer products were superior to the older analogues, sodium penicillin G and tetracycline complex, in the treatment of streptococcal infections in children. We also wished to determine whether there was any evidence that tetracycline resistant streptococci had appeared in our community. Such resistance had been described by Mogabgab and Pelon in 1958,6 and since this study by Kuharic, Roberts, and Kirby (1960)7 andMcCormack, Kaye, and Hook in 1962.4 In addition we conducted a small therapeutic trial to determine the smallest effective dose of phenethicillin. This paper reports our re¬ sults.

Roxithromycin disposition in tonsils after single and repeated administrations

“…Pharyngitis and tonsillitis are among the most common infections encountered in general practice. In these instances group A beta-hemolytic streptococci are the etiologic agents most frequently requiring the institution of antimicrobial treatment, and penicillins and macrolide antibiotics are still considered to be the drugs of choice (3,11). Despite high in vitro susceptibility of Streptococcus pyogenes to these antibiotics, in some instances treatment is ineffective, resulting in prolonged disease duration or relapse (4,5).…”