1977
DOI: 10.1001/archderm.113.9.1229
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Beta carotene therapy for erythropoietic protoporphyria and other photosensitivity diseases

Abstract: We treated with high doses of oral beta carotene (Solatene) (15 to 180 mg/day) 133 patients suffering from erythropoietic protoporphyria (EPP), 27 patients with polymorphous light eruption, six patients with solar urticaria, three patients with hydroa aestivale, one patient with porphyria cutanea tarda, and two patients with actinic reticuloid to relieve the photosensitivity associated with these diseases. Eighty-four percent of the patients with erythropoietic protoporphyria increased by a factor of 3 or more… Show more

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Cited by 46 publications
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“…Moreover, other investigators have reported antioxidant activities for retinol and dehydroretinol as well as for many pro-vitamin A compounds, including β - and α -carotenes [ 44 , 45 ]. However, β -carotene is an efficient quencher of singlet oxygen [ 46 ] but vitamin A (i.e., retinol and derivatives) cannot quench singlet oxygen and has a very small capacity to scavenge free radicals [ 47 , 48 ]. In addition, more studies and analysis reported associations for β -carotene than for retinol or vitamin A.…”
Section: Resultsmentioning
confidence: 99%
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“…Moreover, other investigators have reported antioxidant activities for retinol and dehydroretinol as well as for many pro-vitamin A compounds, including β - and α -carotenes [ 44 , 45 ]. However, β -carotene is an efficient quencher of singlet oxygen [ 46 ] but vitamin A (i.e., retinol and derivatives) cannot quench singlet oxygen and has a very small capacity to scavenge free radicals [ 47 , 48 ]. In addition, more studies and analysis reported associations for β -carotene than for retinol or vitamin A.…”
Section: Resultsmentioning
confidence: 99%
“…As consequence, vitamin E stops the production of ROS formed when fat undergoes oxidation [ 78 ] preventing propagation of damage to cell membranes by peroxyl radicals formed by the oxidation of lipids to stabilize the membrane structure by terminating the free radical chain reaction [ 78 , 79 , 80 ]. Research in animals has allowed to evaluate the use of vitamin E supplements on periodontal diseases and its possible role on ROS and inflammatory processes associated with this conditions [ 46 , 47 ]. In a rat model of periodontitis induced by ligatures, vitamin E supplements prevented increases in malondialdehyde levels and immunoreactivity to inducible nitric oxide synthase (iNOS), but did not decrease ABL [ 61 ].…”
Section: Resultsmentioning
confidence: 99%
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