Beta-Blockers in Isolated Blunt Head Injury

Inaba, Kenji; Teixeira, Pedro G.R.; David, Jean; Chan, Linda S.; Salim, Ali; Brown, Carlos; Browder, Timothy; Beale, Elizabeth; Rhee, Peter; Δημητριάδης, Δημήτριος

doi:10.1016/j.jamcollsurg.2007.10.005

Cited by 116 publications

(99 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…57 Positive effects of ␤-blockade on outcome have also been reported in patients with traumatic brain injury. 58,59 The use of ␤-blockers in acute human stroke may appear controversial. Atenolol and propranolol tested in a randomized, controlled study of 302 acute stroke patients showed a trend toward increased death and disability in the treatment group.…”

Section: Baroreflex Modulation: a New Therapeutic Target In Stroke?mentioning

confidence: 99%

Baroreflex: A New Therapeutic Target in Human Stroke?

Sýkora

Diedler

Turčãni

et al. 2009

Stroke

View full text Add to dashboard Cite

Background and Purpose-Autonomic dysfunction, including increased sympathetic drive and blunted baroreflex, has repeatedly been observed in acute stroke. Of clinical importance is that the stroke-related autonomic imbalance seems to be linked to worse outcome after stroke. Here, we discuss the role of baroreflex impairment in acute stroke and its possible pathophysiological and therapeutic relevance. Summary of Review-Possible mechanisms linking baroreflex impairment with unfavorable outcome in stroke may include increased cardiovascular morbidity and mortality, promotion of secondary brain injury due to local inflammation, hyperglycemia, or altered cerebral perfusion. Conclusions-We suggest therefore that the modifying of autonomic functions may have important therapeutic implications in acute ischemic as well as in hemorrhagic stroke. (Stroke. 2009;40:e678-e682.)

show abstract

Section: Baroreflex Modulation: a New Therapeutic Target In Stroke?mentioning

confidence: 99%

Baroreflex: A New Therapeutic Target in Human Stroke?

Sýkora

Diedler

Turčãni

et al. 2009

Stroke

View full text Add to dashboard Cite

show abstract

“…In another study of coronary artery bypass graft patients, Amory et al reported that the use of b-blockers during the operation reduced postoperative cerebral complications [9]. In addition, the administration of b-blockers improved the survival rate of patients with cerebral injury [16][17][18]. Thus, b-blocker use during cardiac operation may have exerted a cerebral protective effect.…”

Section: Discussionmentioning

confidence: 99%

The effect of landiolol on cerebral blood flow in patients undergoing off-pump coronary artery bypass surgery

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Neuroprotective effects are another possible beneficial effect of beta-blockers on the CNS [70][71][72][73][74][75][76][77]. In animal studies, Lysko et al [70] examined the neuroprotective mechanisms underlying the effects of carvedilol on cultured cerebellar neurons and on CA1 hippocampal neurons in gerbils exposed to brain ischemia.…”

Section: Central Nervous System Effectsmentioning

confidence: 99%

Possible indications of beta-blockers in the perioperative period other than prevention of cardiac ischemia

Kikuchi

Saito

2010

J Anesth

View full text Add to dashboard Cite

According to the guidelines of the American College of Cardiology/American Heart Association 2006 for perioperative cardiovascular evaluation for non-cardiac surgery, beta-blocker therapy should be considered for high-risk individuals undergoing vascular surgery or high- and intermediate-risk patients undergoing non-cardiac surgery. This guideline might induce physicians to increasingly use beta-blockers in the hope of preventing perioperative cardiac complications. However, beta-blockers have potential beneficial effects outside the prevention of cardiac events. In addition to reducing anesthetic and analgesic requirements during the perioperative period, beta-blockers have neuroprotective effects in patients with brain trauma and possible effectiveness in the management of intraoperative awareness-induced post-traumatic stress disorder. Moreover, intrathecal administration of beta-blockers may have antinociceptive effects. Physicians need to bear in mind the benefits of beta-blockers for purposes other than preventing cardiac events when applied in the perioperative period, and they should be familiar with the pharmacodynamics and risk-benefit ratio with their use. This review focuses on possible extracardiac indications of beta-blockers.

show abstract

Beta-Blockers in Isolated Blunt Head Injury

Cited by 116 publications

References 25 publications

Baroreflex: A New Therapeutic Target in Human Stroke?

Baroreflex: A New Therapeutic Target in Human Stroke?

The effect of landiolol on cerebral blood flow in patients undergoing off-pump coronary artery bypass surgery

Possible indications of beta-blockers in the perioperative period other than prevention of cardiac ischemia

Contact Info

Product

Resources

About