Beta 2-adrenergic receptor gene association with overweight and asthma in children and adolescents and its relationship with physical fitness

Leite, Neiva; Lazarotto, Leilane; Milano, Gerusa Eisfeld; Titski, Ana Cláudia Kapp; Consentino, Cássio Leandro Mühe; Mattos, Fernanda de; Andrade, Fabiana Antunes; Furtado-Alle, Lupe

doi:10.1016/j.rppede.2015.08.006

Cited by 3 publications

(5 citation statements)

References 21 publications

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“…Individuals carrying the Gln27Glu polymorphism are more prone to develop overweight and obesity-related traits, such as insulin resistance, hypertension and hypertriglyceridaemia (Large et al 1997;Ishiyama-Shigemoto et al 1999;Mori et al 1999;Lange et al 2005;Hsiao & Lin, 2014;Leite et al 2015). For example, Caucasian females homozygous for Gln27Glu had 20 kg greater fat mass and 50% larger adipocytes than females homozygous for GlnGln (Large et al 1997).…”

Section: Beta 2 -Adrenergic Receptor Polymorphisms Impact Body Compos...mentioning

confidence: 99%

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The beta₂‐adrenergic receptor – a re‐emerging target to combat obesity and induce leanness?

Hostrup

Onslev

2021

The Journal of Physiology

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His research focuses on the health-and performance-related benefits of exercise, performance optimization strategies and ergogenic substances. An extensive amount of his research has been devoted to beta 2 -agonist pharmacology with an emphasis on their effects in human skeletal muscle. Johan Onslev is a medical doctor at NEXS whose research interests include metabolism and endocrinology. He has published several papers on the effect of beta 2 -agonists on metabolism in humans.

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Section: Beta 2 -Adrenergic Receptor Polymorphisms Impact Body Compos...mentioning

confidence: 99%

“…2005; Hsiao & Lin, 2014; Leite et al . 2015). For example, Caucasian females homozygous for Gln27Glu had 20 kg greater fat mass and 50% larger adipocytes than females homozygous for GlnGln (Large et al .…”

Section: Beta2‐adrenergic Receptor Polymorphisms Impact Body Compositionmentioning

confidence: 99%

The beta₂‐adrenergic receptor – a re‐emerging target to combat obesity and induce leanness?

Hostrup

Onslev

2021

The Journal of Physiology

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“…The life habits for children and youth are directly related to family and social behavior with the tendency of global increase in sedentary recreation activities 28 and factors such as lack of Vitamin D which are related to poor nutrition, low solar exposure, and decrease in physical activity engagement 3 . These social changes lead to adaptive physiological responses to day-to-day behavior, which are not always favorable to health, especially in individuals who may have a genetic predisposition 6 . Therefore, it is also important to assess cardiorespiratory fitness to diagnose the potential of physical fitness in school-aged youth 8 .…”

Section: Discussionmentioning

confidence: 99%

“…During this time there are important biological, psychological, and social transformations with the adoption of life-long patterns and behaviors. These can influence the development of comorbidities associated to obesity 5 , considered a multifactorial causality that involves genetic, physiological, environmen-tal, cultural, social, and psychological aspects 6,7 .…”

Section: Introductionmentioning

confidence: 99%

Comparison between girls and boys lifestyle profile and physical activity

Tozo

Pereira

Júnior

et al. 2021

Rev Bras Ativ Fís Saúde

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O objetivo deste estudo foi comparar o perfil de estilo de vida e a prática de atividade física entre meninas e meninos. Participaram do estudo 336 escolares, de 11 a 17 anos de de idade (51,5% sexo feminino). Foram avaliados a estatura, massa corporal, maturação sexual e índice de massa corporal escore z (IMC-z). O nível de atividade física (AF) foi analisado pelo International Physical Activity Questionnaire (IPAQ). O estilo de vida foi avaliado por meio do questionário Perfil do Estilo de Vida Individual (PEVI), analisando ototal de escores dos cinco componentes, considerando-se como pontos de corte: >30 pontos = PEVI favorável e ≤30 pontos = PEVI desfavorável. Observou-se que 35,1% dos escolares foram considerados acima do peso, 74,78% não cumprem as recomendações de atividade física e 31,5% apresentaram PEVI desfavorável. Existiu diferença entre meninos e meninas para a prática de atividade física moderada e vigorosa (AFMV) (p = 0,048). Os meninos apresentaram melhor estilo de vida (p = 0,06) e praticam em média mais AF leve (p < 0,01), AF moderada (p < 0,01), AF vigorosa (p < 0,01) e AFMV (p < 0,01) do que meninas. Enquanto as meninas com PEVI favorável praticam em média mais AF leve do que aquelas com PEVI desfavorável (p < 0,001). Concluiu-se que meninos praticam mais AF na semana em relação às meninas, entretanto possuem menor preocupação com comportamentos preventivos e relacionamentos. A prática de AF leve foi maior em meninas com perfil de estilo de vida favorável.

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“…Studies conducted with overweight adults and adolescents indicated higher total cholesterol values for 27Glu allele carriers and suggested a contribution of the 27Glu allele to the development of obesity and asthma. 9,29 The interaction between Gln27Glu polymorphism, physical activity and body adiposity has been suggested. In both sedentary 6,11 and active groups 5 , as well as in the rates of fat oxidation in adults.…”

Section: Discussionmentioning

confidence: 99%

Adrb2 Gln27glu Polymorphism Associated With Adiposity Indicators and Il-10 in Adolescents

Jesus

Alle

Tureck

et al. 2019

Rev Bras Med Esporte

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Introduction: Studies of association between obesity and genetic factors have demonstrated a significant contribution of polymorphisms related to body fat distribution and subclinical inflammatory process. Objective: To investigate the association between genotypes of the Gln27Glu polymorphism of the ADRB2 gene and indicators of adiposity, inflammatory markers, metabolic parameters and parameters of physical fitness in overweight adolescents. Methods: A total of 44 male and female adolescents, aged between 13 and 17 years, with positive clinical diagnosis of overweight, were divided into two groups according to the Gln27Glu polymorphism genotypes of the ADRB2 gene: a) Group of carriers of the 27Glu allele (Gln27Glu/Glu27Glu) (n = 22); b) Group of non-carriers of the 27Glu allele (Gln27Gln) (n = 22). Both groups were evaluated for body composition, sexual maturation, cardiorespiratory fitness variables and indicators of muscle strength. Basal glycemia and insulin, lipid profile and inflammatory profile were measured. Abdominal subcutaneous and visceral adiposities were evaluated by ultrasonography. Genotyping of the Gln27Glu polymorphism of the ADRB2 gene was performed by the Taqman allelic discrimination assay. Results: The genotype frequency found was: Gln/Gln (n = 22) (50.0%), Gln/Glu (n = 18) (41.0%) and Glu/Glu (n = 4) %). The frequency of the 27Glu allele was 29.5%. The group of adolescent carriers of the 27Glu allele of the ADRB2 gene presented higher mean adiposity indicators (abdominal circumference, trunk fat mass and visceral fat), as well as lower IL-10 concentrations when compared to non-carriers. Conclusions: The 27Glu allele was associated with adiposity indicators in overweight adolescents, while subcutaneous abdominal fat exhibited an inverse relationship with inflammatory variables and maximum oxygen uptake, which may result in more damage to health. Level of evidence III; Case-control study.

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Beta 2-adrenergic receptor gene association with overweight and asthma in children and adolescents and its relationship with physical fitness

Cited by 3 publications

References 21 publications

The beta₂‐adrenergic receptor – a re‐emerging target to combat obesity and induce leanness?

The beta₂‐adrenergic receptor – a re‐emerging target to combat obesity and induce leanness?

Comparison between girls and boys lifestyle profile and physical activity

Adrb2 Gln27glu Polymorphism Associated With Adiposity Indicators and Il-10 in Adolescents

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Beta 2-adrenergic receptor gene association with overweight and asthma in children and adolescents and its relationship with physical fitness

Cited by 3 publications

References 21 publications

The beta2‐adrenergic receptor – a re‐emerging target to combat obesity and induce leanness?

The beta2‐adrenergic receptor – a re‐emerging target to combat obesity and induce leanness?

Comparison between girls and boys lifestyle profile and physical activity

Adrb2 Gln27glu Polymorphism Associated With Adiposity Indicators and Il-10 in Adolescents

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The beta₂‐adrenergic receptor – a re‐emerging target to combat obesity and induce leanness?

The beta₂‐adrenergic receptor – a re‐emerging target to combat obesity and induce leanness?