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Cited by 42 publications
(49 citation statements)
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“…Multivitamin formulations (containing biotin in microgram amounts) do not elevate plasma biotin concentrations sufficiently to interfere with immunoassays. However, high-dose biotin supplements or novel treatments with very high biotin doses for patients with multiple sclerosis have increased concerns about biotin interference [80]. In streptavidin-biotin binding immunoassays using a sandwich format, such as hs-cTn assays, the presence of biotin may decrease the signal intensity producing falsely low results that may go undetected and lead to potentially serious clinical implications such as inappropriate patient discharge.…”
Section: Understanding the Impact Of Pre-analytical And Analytical Inmentioning
confidence: 99%
“…Multivitamin formulations (containing biotin in microgram amounts) do not elevate plasma biotin concentrations sufficiently to interfere with immunoassays. However, high-dose biotin supplements or novel treatments with very high biotin doses for patients with multiple sclerosis have increased concerns about biotin interference [80]. In streptavidin-biotin binding immunoassays using a sandwich format, such as hs-cTn assays, the presence of biotin may decrease the signal intensity producing falsely low results that may go undetected and lead to potentially serious clinical implications such as inappropriate patient discharge.…”
Section: Understanding the Impact Of Pre-analytical And Analytical Inmentioning
confidence: 99%
“…Several independent studies have already confirmed much higher-than-manufacturer-reported interference thresholds in other assays. 36 To our knowledge, no other work group has evaluated biotin interference in Elecsys assays for toxoplasma IgM and toxoplasma IgG. Additional investigation will be required to further evaluate the results obtained for FT3, FT4, cortisol, toxoplasma IgM, and toxoplasma IgG.…”
Section: Discussionmentioning
confidence: 97%
“…32 Alternatives to biotin depletion for the evaluation of discrepant assay results in non-time-critical situations include discontinuation of biotin supplementation and repeated analysis after biotin clearance, serial dilution of samples, and repeat testing on an alternate platform. 36 As described above, each of these approaches suffers from specific drawbacks: serial dilutions can be time-consuming and overdilution can lead to inaccurate results, whereas repeat testing on an alternate platform usually requires sending samples to a reference laboratory for testing. Repeated analysis after biotin discontinuation and clearance might not be possible, because patients may not be available upon recognition of potential biotin interference.…”
Section: Discussionmentioning
confidence: 99%
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