Beryllium Granulomas of the Skin

Granulomatous Dermatitis and Others

“…There are two patterns of berylliosis: systemic berylliosis and localized beryllium granulomas. The skin lesion of berylliosis eventually becomes ulcerated [70]. Regarding aluminum, single or multiple nodules may be seen after the injection of vaccines or allergen desensitization extracts containing absorbed aluminum [71].…”

The granulomatous reaction pattern

“…149 Fibrinoid necrosis is said to be quite common in the cutaneous lesions of black South Africans. 188,189 Other foreign bodies capable of inducing sarcoidal granulomas include acrylic and nylon fibers, wheat stubble, and sea urchin spines. Fibrosis is In the past, cutaneous granulomatous lesions with histology similar to sarcoidosis have been reported in persons exposed to beryllium compounds in industry.…”

“…133 Based on these results the authors concluded that this organism cannot be considered as the etiological agent of the disease. These diseases are considered with the miscellaneous granulomatous diseases (see p. 188). 134 Several studies have reported increased T-helper (Th)-1 cytokines with increased levels of tumor necrosis factor (TNF)-α in patients with sarcoidosis.…”