Beryllium disease: assessment with CT.

Newman, Lee S.; Buschman, Dennis L.; Newell, JD; Lynch, David A.

doi:10.1148/radiology.190.3.8115636

Cited by 74 publications

(33 citation statements)

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“…16, 17) are similar to those of sarcoidosis 44 and include small nodules distributed along the bronchovascular bundles, smooth or nodular interlobular septal thickening, ground glass opacity, and bronchial wall thickening. Mediastinal and hilar lymphadenopathy occurs less frequently than in sarcoidosis, present in only about 25% of patients.…”

Section: Berylliosismentioning

confidence: 87%

Occupational Lung Disease

Sirajuddin

Kanne

2009

Journal of Thoracic Imaging

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Despite federally mandated safety standards, occupational lung disease remains one of the most common work-related injuries. Inhaled dust can result in a range of tissue injury in the lung and can lead to significant respiratory insufficiency causing death. Although silicosis and coal worker's pneumoconiosis are becoming less common, hypersensitivity pneumonitis is increasingly recognized as an occupational lung disease with new antigens being introduced annually. Imaging, particularly high-resolution computed tomography, is central to the management of occupational lung disease and is useful in diagnosis, assessment of disease activity, and evaluating response to therapy.

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Section: Berylliosismentioning

confidence: 87%

Occupational Lung Disease

Sirajuddin

Kanne

2009

Journal of Thoracic Imaging

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“…We recently examined whether thin-section CT would improve our ability to recognize CBD noninvasively (25). Chest radiography was compared with thin-section CT in a group of 15 CBD patients who had abnormal chest radiographs and a second group of 13 patients who had normal chest radiographs as read by certified B-reader using the International Labor Organization (ILO) Classification.…”

Section: Introductionmentioning

confidence: 99%

The natural history of beryllium sensitization and chronic beryllium disease.

Newman

Lloyd

Daniloff

1996

Environ Health Perspect

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With the advent of in vitro immunologic testing, we can now detect exposed individuals who are sensitized to beryllium and those who have chronic beryllium disease (CBD) with lung pathology and impairment. Earlier detection and more accurate diagnostic tools raise new questions about the natural history of sensitization and granulomatous disease. Preliminary data suggest that early detection identifies people who are sensitized to beryllium and that these individuals are at risk for progressing into clinical disease. This article discusses the historical, recent, and ongoing studies germane to our understanding of CBD natural history, including the immunologic and inflammatory basis of the disease, the environmental and host risk factors for disease progression, biological markers of disease severity and activity that may help predict outcome, and the implications for broad-based workplace screening to identify patients at the earliest stages of beryllium sensitization and disease. Environ Health Perspect 104(Suppl 5): 937-943 (1996)

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“…Numerous animal studies have also shown the Ni carcinogenicity through inhalation, intravenous and intramuscular parenteral administration of ground Ni complexes [71]. The toxicity of Be is well known due to chronic beryllium respiratory disease, or berylliosis, that is caused by the inhalation of Be fumes or dust [72]. Therefore, Agbearing ZrCuAlAg BMG, free of toxic elements, possesses excellent in vivo and in vitro biocompatibility.…”

Section: Discussionmentioning

confidence: 99%