Berberis alkaloids XXXII. Berberal — A new alkaloid fromBerberis heterobotrys

Anti-inflammatory and cytotoxic chemical constituents from the trunks of Berberis wallichiana

“…The phytochemical investigation of B. wallichiana root led to the isolation of five alkaloids. These compounds were also determined in other Berberis species as reported previously, with considerable bioactivities such as antitumors, antimicrobial, and antiinflammation activities (Karimov et al 1993;Mokhber-Dezfuli et al 2014;Imenshahidi and Hosseinzadeh 2016;Khan et al 2016). The present study investigated anticancer activities of B. wallichiana total extract, non-alkaloid fraction, and alkaloids enriched fraction, together with the isolated compounds.…”

“…However, the disappearance of amide proton, together with the appearance of a signal of a highly oxidized sp 3 methine (at δC 89.7 ppm), signals of an aromatic ring, and two methoxy groups revealed the substitution in the amide group. Comparison of NMR spectra of compound 5 with the reported data indicated it to be berberal (Karimov et al 1993).…”

Bisbenzylisoquinoline Alkaloids

“…(61), 206(8), 205(18), 192(71), 191(16), 190(48), 174(38), 58 (72)85 source: Stephania tetrandra (Menispermaceae)85 derivatives: (+)-2,2′-N,N-dimethyltetrandrine (2-N-methylfangchinoline + MeI/KOH)85 Reviews…”

“…(cultured roots) 29 Liensinine (C 37 H 42 O 6 N 2 : 610.3043) Nelumbo nucifera (Nymphaeaceae) , 31 Aromoline (C 36 H 38 O 6 N 2 : 594.2730) Berberis heteropoda (Berberidaceae), B. nummularia , B. waziristanica , Stephania cepharantha (Menispermaceae), , Thalictrum fortunei (Ranunculaceae) 33 Cepharanoline (C 36 H 36 O 6 N 2 : 594.2573) Stephania cepharantha (Menispermaceae), , S. epigaea 34 Cepharanthine (C 37 H 38 O 6 N 2 : 606.2730) Stephania cepharantha (Menispermaceae), ,, S. erecta 35 Coclobine (C 37 H 38 O 6 N 2 : 606.2730) Anisocycla cymosa (Menispermaceae) 36 Cycleapeltine (C 37 H 40 O 6 N 2 : 608.2886) Cyclea barbata (Menispermaceae) 6 37 Daphnandrine (C 36 H 38 O 6 N 2 : 594.2730) Anisocycla cymosa (Menispermaceae), Cyclea barbata (Menispermaceae), Stephania erecta (Menispermaceae) 34 38 Daphnoline (C 35 H 36 O 6 N 2 : 580.2573) Pachygone dasycarpa (Menispermaceae) 9 42 Homoaromoline (C 37 H 40 O 6 N 2 : 608.2886) Anisocycla jollyana (Menispermaceae), Cyclea barbata (Menispermaceae), 6 Stephania cepharantha (Menispermaceae), , S. erecta , S. excentrica 46 Obaberine (C 38 H 42 O 6 N 2 : 622.3043) Berberis heterobotrys (Berberidaceae), B. iliensis , B. koreana , B. valdiviana , Stephania erecta (Menispermaceae), Thalictrum minus var. majus (Ranunculaceae) 46dvt 2-Norobaberine (C 37 H 40 O 6 N 2 : 608.2886) Anisocycla cymosa (Menispermaceae), Stephania erecta (Menispermaceae) 34 ...…”

“…majus (Ranunculaceae) 41 49 Repandine (C 37 H 40 O 6 N 2 : 608.2886) Cyclea barbata (Menispermaceae) 7 52a Thaligosine (C 38 H 42 O 7 N 2 : 638.2992) Thalictrum foetidum (Ranunculaceae), T. minus var. majus 41 52b Thaligosinine (C 39 H 44 O 7 N 2 : 638.2992) Thalictrum foetidum (Ranunculaceae), T. fargesii 53 Thalisopidine (C 37 H 40 O 7 N 2 : 624.2836) Thalictrum fargesii (Ranunculaceae), T. isopyroides 55 Thalrugosaminine (C 39 H 44 O 7 N 2 : 638.2992) Thalictrum foetidum (Ranunculaceae) 49 56 Atherospermoline (C 36 H 38 O 6 N 2 : 594.2730) Pachygone dasycarpa (Menispermaceae) 9 57 Berbamine (C 37 H 40 O 6 N 2 : 608.2886) Berberis aggregata (Berberidaceae), B. dictyoneura (Berberidaceae), B. francisci-ferdinandi , B. heterobotrys , B. iliensis , B. pseudothunbergii , B. sibirica , B. vulgaris , Cyclea barbata (Menispermaceae), Stephania cepharantha (Menispermaceae) 28,31,33 60 Cycleanorine (C 37 H 40 O 6 N 2 : 608.2886) Cyclea barbata (Menispermaceae) 7 61 Fangchinoline (C 37 H 40 O 6 N 2 : 608.2886) Pachygone dasycarpa (Menispermaceae), Stephania tetrandra (Menispermaceae), Strychnopsis thouarsii (Menispermaceae) …”