Berberine produces antidepressant-like effects in the forced swim test and in the tail suspension test in mice

Effect of aqueous extract and fractions of Zhi-Zi-Hou-Pu decoction against depression in inescapable stressed mice: Restoration of monoamine neurotransmitters in discrete brain regions

“…Effect of aqueous extract and fractions of Zhi-Zi-Hou-Pu decoction against depression in inescapable stressed mice: Restoration of monoamine neurotransmitters in discrete brain regions traditional Chinese medicine (TCM) and many TCM compounds are receiving more attention for their extensive applications in China (Luo et al, 2000;Li et al, 2003;Peng et al, 2007;An et al, 2008a,b;Zhang et al, 2009;Kwon et al, 2010;Mao et al, 2010;Zhou et al, 2010).…”

Study and Evaluation of Antidepressant Like Property of Ethanolic Seed Extract of Elaeocarpus Ganitrus in Animal Model of Depression

“…The duration of immobility was recorded. Decrease in the period of immobility during the FST was taken as evaluate of antidepressant activity 29,30,31,32 .…”

“…The animal was considered immobile when it did not show any movement of body and hanged passively. The total duration of immobility was noted during last 4 minutes of 6 minute period 31 . All animal was used only once.…”

“…When the animal stops struggling, and hang up itself immobile, it is considered to have "given up". Longer time of immobility is attributing of a depressive-like condition 31,35 .…”

Berberine Exerts Neuroprotective Actions against in Vitro Ischemia-Induced Neuronal Cell Damage in Organotypic Hippocampal Slice Cultures: Involvement of B-Cell Lymphoma 2 Phosphorylation Suppression

“…cortex; these plants are included in several Kampo formulae (traditional Chinese-Korean-Japanese medicine), such as orengedokuto (Huang-Lian-Jie-Du-Tang), and have been used to treat various inflammatory diseases. This alkaloid has multiple pharmacological actions, including anti-inflammatory effects, [19][20][21][22][23][24][25] antipyretic action, 23) diarrhea-treating action, 26) glucose-lowering potential, 27,28) cholesterol-lowering effect, 29) antidepressant action 30,31) and Alzheimer's disease-amelioration effect. 32,33) Moreover, a previous report 34) from this laboratory demonstrated that orengedokuto exhibited a protective effect on transient cere- bral ischemia-induced impairment of learning and memory in mice.…”