Berberine-photodynamic therapy sensitizes melanoma cells to cisplatin-induced apoptosis through ROS-mediated P38 MAPK pathways

Wang, Xiaotong; Gong, Qianyi; Song, Chen; Fang, Jiaping; Yang, Yun; Liang, Xin; Huang, Xuan; Liu, Jianwen

doi:10.1016/j.taap.2021.115484

Cited by 22 publications

(9 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results suggest that curcumin has good effects in raising ROS levels to stimulate apoptosis in cancer cells. In clinical trials of natural products combined with cisplatin for the treatment of melanoma, berberine acted more like a chemosensitizer, effectively activating the ROS/p38/caspase cascade that stimulates melanoma cell death ( 83 ). Moreover, berberine triggers apoptosis-related responses such as cleavage of caspase-3, release of cytochrome c and depolarization of the mitochondrial membrane in non-small cell lung cancer through activation of apoptosis signal-regulated kinase 1 (ASK1) and c-jun NH2 kinase (JNK) via the ROS pathway ( 84 ).…”

Section: Natural Products Possess Anti-tumor Functionmentioning

confidence: 99%

Remodeling tumor microenvironment with natural products to overcome drug resistance

Zhang

et al. 2022

Front. Immunol.

View full text Add to dashboard Cite

With cancer incidence rates continuing to increase and occurrence of resistance in drug treatment, there is a pressing demand to find safer and more effective anticancer strategy for cancer patients. Natural products, have the advantage of low toxicity and multiple action targets, are always used in the treatment of cancer prevention in early stage and cancer supplement in late stage. Tumor microenvironment is necessary for cancer cells to survive and progression, and immune activation is a vital means for the tumor microenvironment to eliminate cancer cells. A number of studies have found that various natural products could target and regulate immune cells such as T cells, macrophages, mast cells as well as inflammatory cytokines in the tumor microenvironment. Natural products tuning the tumor microenvironment via various mechanisms to activate the immune response have immeasurable potential for cancer immunotherapy. In this review, it highlights the research findings related to natural products regulating immune responses against cancer, especially reveals the possibility of utilizing natural products to remodel the tumor microenvironment to overcome drug resistance.

show abstract

Section: Natural Products Possess Anti-tumor Functionmentioning

confidence: 99%

Remodeling tumor microenvironment with natural products to overcome drug resistance

Zhang

et al. 2022

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…Furthermore, nanocarriers can undergo surface modification to enhance their selectivity towards cancer cells. Finally, nanoparticles can provide phototherapy in promoting ROS generation, resulting in an increase in efficacy of CP in cancer chemotherapy (Figure 4) [298,[329][330][331].…”

Section: Nanotherapeuticsmentioning

confidence: 99%

Elucidating Role of Reactive Oxygen Species (ROS) in Cisplatin Chemotherapy: A Focus on Molecular Pathways and Possible Therapeutic Strategies

et al. 2021

View full text Add to dashboard Cite

The failure of chemotherapy is a major challenge nowadays, and in order to ensure effective treatment of cancer patients, it is of great importance to reveal the molecular pathways and mechanisms involved in chemoresistance. Cisplatin (CP) is a platinum-containing drug with anti-tumor activity against different cancers in both pre-clinical and clinical studies. However, drug resistance has restricted its potential in the treatment of cancer patients. CP can promote levels of free radicals, particularly reactive oxygen species (ROS) to induce cell death. Due to the double-edged sword role of ROS in cancer as a pro-survival or pro-death mechanism, ROS can result in CP resistance. In the present review, association of ROS with CP sensitivity/resistance is discussed, and in particular, how molecular pathways, both upstream and downstream targets, can affect the response of cancer cells to CP chemotherapy. Furthermore, anti-tumor compounds, such as curcumin, emodin, chloroquine that regulate ROS and related molecular pathways in increasing CP sensitivity are described. Nanoparticles can provide co-delivery of CP with anti-tumor agents and by mediating photodynamic therapy, and induce ROS overgeneration to trigger CP sensitivity. Genetic tools, such as small interfering RNA (siRNA) can down-regulate molecular pathways such as HIF-1α and Nrf2 to promote ROS levels, leading to CP sensitivity. Considering the relationship between ROS and CP chemotherapy, and translating these findings to clinic can pave the way for effective treatment of cancer patients.

show abstract

“…The degree of colocalization is analyzed using Pearson's correlation coefficient as accepted. 64 Without peptides' treatment, the Pearson's correlation coefficients of the proteins and mitochondria are both higher than 0.8, indicating that HK-II or Cyt-c can colocalize with mitochondria, respectively. The Pearson's correlation coefficients of HK-II or Cyt-c and mitochondria decreased when the A549 cells were treated with 25 μM pHK-pKV or 6.25 μM Pal-pHK-pKV.…”

Section: Resultsmentioning

confidence: 97%

“…The colocalization patterns of the proteins and mitochondria were acquired by a laser scanning confocal microscope. The degree of colocalization is analyzed using Pearson’s correlation coefficient as accepted . Without peptides’ treatment, the Pearson’s correlation coefficients of the proteins and mitochondria are both higher than 0.8, indicating that HK-II or Cyt-c can colocalize with mitochondria, respectively.…”

Section: Resultsmentioning

confidence: 99%

A Lipidated Peptide with Mitochondrial Membrane Localization in Human A549 Lung Cells: From Enhanced Cell-Penetrating Properties to Biological Activity Mechanism

Zhang

Angelova

Sun

et al. 2021

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

Here, a lipidated peptide Pal-pHK-pKV with self-assembly properties and the ability to provoke the disruption of the mitochondrial voltage-dependent anion channel-1 protein (VDAC1)-hexokinase-II (HK-II) complex is reported. The effects of the peptide pHK (N-terminal 15-amino acid fragment of HK-II that specifically binds VDAC1) are compared to those of a designed biomimetic amphiphilic pHK-pKV conjugate (pHK coupled with a cell-penetrating peptide pKV) and Pal-pHK-pKV (a lipidated conjugate modified with a hydrophobic palmitic (Pal) alkyl chain). The Pal-pHK-pKV exhibits a stronger interaction with the membrane as compared to pHK-pKV, which is demonstrated by the Langmuir–Blodgett technique and two-photon excitation microscopy. The amphiphilic peptide derivatives are cytotoxic to the A549 cells, but Pal-pHK-pKV is more cytotoxic. The inhibitory effects of the pHK derivatives on the A549 cells growth are investigated through induced apoptosis pathway, depolarized mitochondrial membrane potential, inhibited glycolysis, and activated caspase. The results of the immunofluorescence evidence the specific mitochondrial targeting by those derivatives.

show abstract

Berberine-photodynamic therapy sensitizes melanoma cells to cisplatin-induced apoptosis through ROS-mediated P38 MAPK pathways

Cited by 22 publications

References 46 publications

Remodeling tumor microenvironment with natural products to overcome drug resistance

Remodeling tumor microenvironment with natural products to overcome drug resistance

Elucidating Role of Reactive Oxygen Species (ROS) in Cisplatin Chemotherapy: A Focus on Molecular Pathways and Possible Therapeutic Strategies

A Lipidated Peptide with Mitochondrial Membrane Localization in Human A549 Lung Cells: From Enhanced Cell-Penetrating Properties to Biological Activity Mechanism

Contact Info

Product

Resources

About