Berberine inhibits the development of endometrial cancer through circ_ZNF608/miR-377-3p/COX2 axis

Liang, Huan; Liu, Yi; Lian, Fang; Li, Ling; Gong, Nianjin

doi:10.1080/08916934.2021.2010050

Cited by 3 publications

(1 citation statement)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is growing evidence that circRNAs are involved in human tumor progression and play an important regulatory function [26]. In EC, some dysregulated circRNAs were also identified, including circ-ATAD1 [27], circ-ZNF608 [28], circ-PUM1 [29], and so on. The high-throughput sequencing results have [20] identified circ-NAB1 as an abnormally expressed circRNA in EC tissues.…”

Section: Discussionmentioning

confidence: 99%

N6-Methyladenosine modified circ-NAB1 modulates cell cycle and epithelialmesenchymal transition via CDKN3 in endometrial cancer

Jun Zhang,

Yang Zhang,

Jinwei Zhang

2024

Cell Mol Biol (Noisy-le-grand)

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

N6-Methyladenosine modified circ-NAB1 modulates cell cycle and epithelialmesenchymal transition via CDKN3 in endometrial cancer

Jun Zhang,

Yang Zhang,

Jinwei Zhang

2024

Cell Mol Biol (Noisy-le-grand)

View full text Add to dashboard Cite

Research progress on pharmacological effects and bioavailability of berberine

Cui,

Zhou,

Jin

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

View full text Add to dashboard Cite

Cancer Pathways Targeted by Berberine: Role of microRNAs

Ali,

Mishra,

Singh

2024

CMC

View full text Add to dashboard Cite

Cancer is a complex and heterogeneous malignant disease. Due to its multifactorial nature, including progressive changes in genetic, epigenetic, transcript, and protein levels, conventional therapeutics fail to save cancer patients. Evidence indicates that dysregulation of microRNA (miRNA) expression plays a crucial role in tumorigenesis, metastasis, cell proliferation, differentiation, metabolism, and signaling pathways. Moreover, miRNAs can be used as diagnostic and prognostic markers and therapeutic targets in cancer. Berberine, a naturally occurring plant alkaloid, has a wide spectrum of biological activities in different types of cancers. Inhibition of cell proliferation, metastasis, migration, invasion, and angiogenesis, as well as induction of cell cycle arrest and apoptosis in cancer cells, is reported by berberine. Recent studies suggested that berberine regulates many oncogenic and tumor suppressor miRNAs implicated in different phases of cancer. This review discussed how berberine inhibits cancer growth and propagation and regulates miRNAs in cancer cells. And how berberine-mediated miRNA regulation changes the landscape of transcripts and proteins that promote or suppress cancer progression. Overall, the underlying molecular pathways altered by berberine and miRNA influencing the tumor pathophysiology will enhance our understanding to combat the malignancy.

show abstract

Berberine inhibits the development of endometrial cancer through circ_ZNF608/miR-377-3p/COX2 axis

Cited by 3 publications

References 31 publications

N6-Methyladenosine modified circ-NAB1 modulates cell cycle and epithelialmesenchymal transition via CDKN3 in endometrial cancer

N6-Methyladenosine modified circ-NAB1 modulates cell cycle and epithelialmesenchymal transition via CDKN3 in endometrial cancer

Research progress on pharmacological effects and bioavailability of berberine

Cancer Pathways Targeted by Berberine: Role of microRNAs

Contact Info

Product

Resources

About