Berberine Improves Kidney Injury Following Renal Ischemia Reperfusion in Rats

Gholampour, Firouzeh; Moghadam, Seyed Moslem Fatemi; Owji, Seyed Mohammad

doi:10.3923/ijzr.2015.9.18

Cited by 4 publications

(3 citation statements)

References 34 publications

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“…Berberine pretreatment has been shown to attenuate ischemia/reperfusion injury by suppression of mitochondrial stress and endoplasmic reticulum stress pathways (Yu et al ., ). Berberine has also an ameliorative effect on pulmonary and hepatic injuries following renal ischemia/reperfusion in rats (Gholampour et al ., ; Gholampour et al ., ).…”

Section: Renal Effectsmentioning

confidence: 97%

Berberis Vulgaris and Berberine: An Update Review

Imenshahidi

Hosseinzadeh

2016

Phytotherapy Research

237

174

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Berberine is an isoquinoline alkaloid present in several plants, including Coptis sp. and Berberis sp. Berberine is a customary component in Chinese medicine, and is characterized by a diversity of pharmacological effects. An extensive search in electronic databases (PubMed, Scopus, Ovid, Wiley, ProQuest, ISI, and Science Direct) were used to identify the pharmacological and clinical studies on Berberis vulgaris and berberine, during 2008 to 2015, using 'berberine' and 'Berberis vulgaris' as search words. We found more than 1200 new article studying the properties and clinical uses of berberine and B. vulgaris, for treating tumor, diabetes, cardiovascular disease, hyperlipidemia, inflammation, bacterial and viral infections, cerebral ischemia trauma, mental disease, Alzheimer disease, osteoporosis, and so on. In this article, we have updated the pharmacological effects of B. vulgaris and its active constituent, berberine. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Renal Effectsmentioning

confidence: 97%

Berberis Vulgaris and Berberine: An Update Review

Imenshahidi

Hosseinzadeh

2016

Phytotherapy Research

237

174

View full text Add to dashboard Cite

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“…Also, during a study, the administration of naringenin reduced apoptosis, inflammation, and liver tissue damage caused by renal ischemia-reperfusion [ 27 ]. Berberine, with its antioxidant and anti-inflammatory activity, reduces liver dysfunction caused by renal ischemia-reperfusion in rats [ 28 ]. Alpha-lipoic acid as an antioxidant also reduced kidney damage in diabetic rats [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Thyme Essential Oil on Liver Injuries Caused by Renal Ischemia-Reperfusion in Rats

Rostami

Eslamifar

Nazemi

et al. 2022

BioMed Research International

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Liver damage occurs following renal ischemia-reperfusion (RIR) that can cause inflammation and inflammatory cytokines activated after kidney injury. In this study, thyme essential oil (TE) with antioxidant and anti-inflammatory properties was used to reduce liver damage induced by renal IR. 32 male rats were randomly divided into 4 equal groups: (1) control, (2) RIR, (3) RIR+TE, and (4) TE. Rats received TE as a pretreatment at a dose of 0.5 ml/kg for one week. Then, under anesthesia for 45 minutes for ischemia, the kidneys of the animals were closed with clamps, and reperfusion was performed for 24 hours. Animal serum was isolated to evaluate alkaline phosphatase (ALP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) parameters. The liver of rats was examined for the measurement of malondialdehyde (MDA), nitric oxide (NO), glutathione (GSH), glutathione peroxidase (GPX), catalase (CAT), and expression of genes such as interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and caspase-3. ALP, AST, ALT, MDA, NO, IL-6, TNF-α, and caspase-3 increased significantly in the RIR group compared to the control group ( p < 0.05 ). GSH, GPX, and CAT decreased significantly in the RIR group compared to the control group ( p < 0.05 ). TE caused a decrease in ALP, AST, ALT, MDA, NO, IL-6, and TNF-α compared to the RIR group and caused an increase in the amount of GSH, GPX, and CAT in the RIR group ( p < 0.05 ). This study showed that TE has antioxidant and anti-inflammatory properties that reduce liver damage induced by RIR.

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“…RIRI is the leading cause of acute kidney injury (AKI), which is characterized by a sudden decline in renal function, glomerular filtration rate (GFR) reduction, accumulation of nitrogen waste products, and inability to maintain fluid and electrolyte homeostasis [4][5][6]. Molecular mechanisms underlying RIRI-induced AKI are not fully understood, but it has been reported that several factors such as ATP depletion, reactive oxygen species (ROS) production, phospholipase activation, neutrophil infiltration, and release of vasoactive peptides contribute to the pathogenesis of renal damage [7][8][9][10]. Among the diverse mediators that take part in AKI induced by RIRI, the renin-angiotensin system (RAS) plays an important role [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

View of the Renin-Angiotensin System in Acute Kidney Injury Induced by Renal Ischemia-Reperfusion Injury

Karimi¹,

Maleki

Nematbakhsh

2022

J Renin Angiotensin Aldosterone Syst

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Renal ischemia-reperfusion injury (RIRI) is a sequence of complicated events that is defined as a reduction of the blood supply followed by reperfusion. RIRI is the leading cause of acute kidney injury (AKI). Among the diverse mediators that take part in RIRI-induced AKI, the renin-angiotensin system (RAS) plays an important role via conventional (angiotensinogen, renin, angiotensin-converting enzyme (ACE), angiotensin (Ang) II, and Ang II type 1 receptor (AT1R)) and nonconventional (ACE2, Ang 1-7, Ang 1-9, AT2 receptor (AT2R), and Mas receptor (MasR)) axes. RIRI alters the balance of both axes so that RAS can affect RIRI-induced AKI. In overall, the alteration of Ang II/AT1R and AKI by RIRI is important to consider. This review has looked for the effects and interactions of RAS activities during RIRI conditions.

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Berberine Improves Kidney Injury Following Renal Ischemia Reperfusion in Rats

Cited by 4 publications

References 34 publications

Berberis Vulgaris and Berberine: An Update Review

Berberis Vulgaris and Berberine: An Update Review

The Effect of Thyme Essential Oil on Liver Injuries Caused by Renal Ischemia-Reperfusion in Rats

View of the Renin-Angiotensin System in Acute Kidney Injury Induced by Renal Ischemia-Reperfusion Injury

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