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Cited by 155 publications
(88 citation statements)
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References 24 publications
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“…Chromatin condensation caused by DNA fragmentation is a typical feature of apoptotic cells (31). In the present study, although we did not observe DNA fragmentation in FaDu cells treated with berberine, chromatin condensation was observed, as shown in Fig.…”
Section: Discussioncontrasting
confidence: 47%
“…Chromatin condensation caused by DNA fragmentation is a typical feature of apoptotic cells (31). In the present study, although we did not observe DNA fragmentation in FaDu cells treated with berberine, chromatin condensation was observed, as shown in Fig.…”
Section: Discussioncontrasting
confidence: 47%
“…In addition, diVerent cells lines exhibit signiWcantly diVerent sensitivities to this alkaloid. For example, almost two orders of magnitude diVerence in IC 50 values were reported in the same study for leukemia and melanoma cell lines [40].…”
Section: Discussionmentioning
confidence: 57%
“…However, berberine can arrest gastric carcinoma [11] and HL-60 leukemia cells in G2/M [39]. In contrast, berberine has been reported to have little eVect on cell cycle traverse in U937 leukemia and B16 melanoma cell lines [40]. Our results with K1735-M2 melanoma cells show that the exact nature of cell cycle perturbation depends on the concentration of berberine used, with lower concentrations resulting in G1 arrest, and higher concentrations leading to a G2 arrest.…”
Section: Discussionmentioning
confidence: 72%
“…Although unexpected, this was in agreement with a previous report showing that berberine induces cell lysis ⁄ necrosis in murine melanoma B16 cells. (34) We also investigated the signaling molecules that might be involved in berberine-induced HCC cell death. Our results showed that berberine significantly decreased the expression of CD147 at the protein level.…”
Section: Discussionmentioning
confidence: 99%