�ber den Stoffwechsel des menschlichen Herzens

Doll, E; Keul, J.; Steim, H; Maiwald, C; Reindell, H

doi:10.1007/bf00363206

Cited by 28 publications

(2 citation statements)

References 23 publications

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“…Received for publication 18 October 1968 and in revised form 4 February 1969. myocardial metabolism, numerous investigations have confirmed this observation (3)(4)(5)(6)(7). In addition, it has been established that plasma FFA are the major myocardial substrate in the postabsorptive state in man (3,8,9).…”

Section: Introductionmentioning

confidence: 84%

Free fatty acid metabolism of the human heart at rest

Most¹,

Brachfeld²,

Gorlin³

et al. 1969

J. Clin. Invest.

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A B S T R A C T Myocardial substrate metabolism was studied in 13 subjects at the time of diagnostic cardiac catheterization by means of palmitic acid-14C infusion with arterial and coronary sinus sampling. Two subjects were considered free of cardiac pathology and all, with one exception, demonstrated lactate extraction across the portion of heart under study. Data for this single lactate-producing subject were treated separately.The fractional extraction of '4C-labeled free fatty acids (FFA) (44.4+±9.5%) was nearly twice that of unlabeled FFA (23.2 ±7.8%) and raised the possibility of release of FFA into the coronary sinus. FFA uptake, based on either the arterial minus coronary sinus concentration difference or the FFA-14C fractional extraction, was directly proportional to the arterial FFA concentration. Gas-liquid chromatography failed to demonstrate selective handling of any individual FFA by the heart. Fractional oxidation of FFA was 53.5 ±+12.7%, accounting for 53.2 ±14.4% of the heart's oxygen consumption while nonlipid substrates accounted for an additional 30.0 ±17.3%. Determinations of both labeled and unlabeled triglycerides suggested utilization of this substrate by the fasting human heart. Direct measurement of FFA fractional oxidation as well as FFA uptake, exclusive of possible simultaneous FFA release, would appear necessary in studies concerned with human myocardial FFA metabolism.

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Section: Introductionmentioning

confidence: 84%

Free fatty acid metabolism of the human heart at rest

Most¹,

Brachfeld²,

Gorlin³

et al. 1969

J. Clin. Invest.

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show abstract

“…In addition to the brain, lactate has also been reported as preferred fuel under stress/strain conditions in heart and skeletal muscle, and perhaps lactate also serves as a signaling molecule in such conditions (reviewed in Ref ). Already moderate physical activity doubled the contribution of lactate for total cardiac energy production in healthy subjects , while heavy exercise (at 200 W) increased lactate uptake by a factor of four, with a 60% contribution to cardiac energy production . Studies on rats demonstrated that increased blood lactate levels can have positive effects on heart function during a septic or hemorrhagic shock .…”

mentioning

confidence: 99%

Catalytically inactive carbonic anhydrase‐related proteins enhance transport of lactate by MCT1

et al. 2019

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Carbonic anhydrases (CA) catalyze the reversible hydration of CO 2 to protons and bicarbonate and thereby play a fundamental role in the epithelial acid/base transport mechanisms serving fluid secretion and absorption for whole‐body acid/base regulation. The three carbonic anhydrase‐related proteins (CARPs) VIII, X, and XI, however, are catalytically inactive. Previous work has shown that some CA isoforms noncatalytically enhance lactate transport through various monocarboxylate transporters (MCT). Therefore, we examined whether the catalytically inactive CARPs play a role in lactate transport. Here, we report that CARP VIII, X, and XI enhance transport activity of the MCT MCT1 when coexpressed in Xenopus oocytes, as evidenced by the rate of rise in intracellular H+ concentration detected using ion‐sensitive microelectrodes. Based on previous studies, we suggest that CARPs may function as a ‘proton antenna’ for MCT1, to drive proton‐coupled lactate transport across the cell membrane.

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Myocardial Metabolism in Athletes

Keul

1971

Advances in Experimental Medicine and Biology

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�ber den Stoffwechsel des menschlichen Herzens

Cited by 28 publications

References 23 publications

Free fatty acid metabolism of the human heart at rest

Free fatty acid metabolism of the human heart at rest

Catalytically inactive carbonic anhydrase‐related proteins enhance transport of lactate by MCT1

Myocardial Metabolism in Athletes

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