Biochemical Pharmacology volume 82, issue 5, P535-547 2011 DOI: 10.1016/j.bcp.2011.05.028 View full text
Kyril Turpaev, Mikhail Ermolenko, Thierry Cresteil, Jean Claude Drapier

Abstract: Benzylidenemalononitrile (BMN) tyrphostins are well known as potent tyrosine kinase inhibitors. Moreover, in recent years it has been recognized that members of the tyrphostin family possess additional biological activities independent of their ability to inhibit protein tyrosine kinases. In this study, we examined the relationship between the structure of 49 BMNs and related compounds, and their capacity to induce heme oxygenase 1 (HO-1) gene expression in U937 human monocytic cells, to activate upstream sign…

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