Benzothiazole carbamates and amides as antiproliferative species

Videnović, Milica; Mojsin, Marija; Stevanović, Milena; Opsenica, Igor; Srdiċ-Rajiċ, Tatjana; Šolaja, Bogdan A.

doi:10.1016/j.ejmech.2018.08.067

Cited by 13 publications

(2 citation statements)

References 59 publications

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“…BTA derivatives have been widely used in the development of antitumor drugs, especially molecularly targeted antitumor drugs, because of their easy synthesis 26 . One study found that the benzothiazole derivative carbamate showed antiproliferative activity against NT2/D1 cells 27 . And a report found that AFN01 (benzothiazole derivative) inhibited cell proliferation in a model gastric cancer cell line 28 .…”

Section: Discussionmentioning

confidence: 99%

“…26 One study found that the benzothiazole derivative carbamate showed antiproliferative activity against NT2/D1 cells. 27 And a report found that AFN01 (benzothiazole derivative) inhibited cell proliferation in a model gastric cancer cell line. 28 In this study, we examined the responses of OVCAR420 and SKOV3 cells to different concentrations of Rosline.…”

Section: Discussionmentioning

confidence: 99%

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Rosline promotes p21 expression to inhibit ovarian cancer cell proliferation via p53‐independent pathway

Xiao

et al. 2023

J of Obstet and Gynaecol

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Aim To investigate the effect of benzothiazole derivatives (Rosline) on ovarian cancer and the potential mechanism. Methods Ovarian cancer tissues were collected clinically and immunohistochemistry was used to detect the expression of p53 and p21. Ovarian cancer cells were exposed to 0, 2.5, 5, 10 μmol/L Rosline for 24 h. 100 nmol/L Pifithrin‐α pre‐incubation was used to inhibit the transcriptional activity of p53. CCK‐8 and BrdU assays were used to detect the effects of different concentrations of rosline on the proliferation and cell cycle of OVCAR420 and SKOV3 cells. Flow cytometry assay was used to detect cell cycle. The transcriptional and translational expression of p21 and p53 were detected by RT‐qPCR and Western blot. Results p21 was expressed in ovarian cancer tissues without p53 expression. Rosline inhibits the proliferation of ovarian cancer cells and blocks the cell cycle progression. Meanwhile, Rosline promotes p21 expression in ovarian cancer cells at both mRNA and protein levels, but with no significant effect on p53 expression. Besides, Rosline promotes p21 expression, inhibits cell proliferation, and blocks the cell cycle via the p53‐independent pathway. Conclusion Rosline promoted p21 expression thereby inhibiting cell proliferation and blocks the cell cycle via p53‐independent pathway.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Rosline promotes p21 expression to inhibit ovarian cancer cell proliferation via p53‐independent pathway

Xiao

et al. 2023

J of Obstet and Gynaecol

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Solid‐Supported Materials‐Based Synthesis of 2‐Substituted Benzothiazoles: Recent Developments and Sanguine Future

et al. 2021

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Benzothiazole and its derivatives have been manifested as an optimistic scaffold due to their immense biological importance. Several methodologies have been reported as modifications after the first report of 2-substituted benzothiazole. Among them, many involve a shift from the conventional synthetic approach by utilizing different catalytic systems. Moreover, synthetic methodologies focused on improvements in terms of product yield, reaction duration, use of environmentally benign conditions and simplified workup procedures predominate among the recently developed approaches. Solid-phase organic synthesis received considerable attention with the pioneering findings of Merrifield's solid-phase peptide synthesis in 1963. A diverse range of organic, inorganic and organic-inorganic substances have been utilized as polymeric solid supports in various catalytic applications. The recyclability and reusability of the immobilized catalysts over consecutive cycles establish them as an attractive alternative over conventional catalytic systems from the environment as well as industrial perspective. The present review summarizes the recent developments in the environmentally benign synthesis of benzothiazole derivatives using supported reagents. Different solid supports along with their catalytic application, mechanistic perspective and substrate tolerance have been discussed comprehensively.

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Synthesis and antibacterial evaluation of novel chalcone derivatives containing a benzothiazole scaffold

Wang

Jiang

et al. 2019

Monatsh Chem

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Benzothiazole carbamates and amides as antiproliferative species

Cited by 13 publications

References 59 publications

Rosline promotes p21 expression to inhibit ovarian cancer cell proliferation via p53‐independent pathway

Rosline promotes p21 expression to inhibit ovarian cancer cell proliferation via p53‐independent pathway

Solid‐Supported Materials‐Based Synthesis of 2‐Substituted Benzothiazoles: Recent Developments and Sanguine Future

Synthesis and antibacterial evaluation of novel chalcone derivatives containing a benzothiazole scaffold

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