Benzo[a]pyrene Uptake by Serum Lipids: Correlation with Triglyceride Concentration

Yoo, Jeong-Sook H.; Norman, James O’Higgins; Busbee, David L.

doi:10.3181/00379727-177-41969

Cited by 8 publications

(4 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the case of TCDD, its distribution into adipose tissue is greater at low exposure levels 29. Obese persons tend to have higher lipid levels in circulation, and in the case of lipophilic chemicals whose blood concentrations are dependent on blood lipid levels, whole blood chemical quantities may appear higher in obese persons than lean persons even if total body burdens are equivalent 32,33. In other words, the dilution effect of higher body mass may be masked by higher blood lipids when sampling serum or whole blood to assess lipophilic chemical exposure.…”

Section: Unique Susceptibility Of Obese Children and Adolescentsmentioning

confidence: 99%

Childhood Obesity and Environmental Chemicals

Merrill

Birnbaum

2011

Mount Sinai J Medicine

152

113

View full text Add to dashboard Cite

Childhood and adolescent rates of obesity and overweight are continuing to increase in much of the world. Risk factors such as diet composition, excess caloric intake, decreased exercise, genetics, and the built environment are active areas of etiologic research. The obesogen hypothesis, which postulates that prenatal and perinatal chemical exposure can contribute to risk of childhood and adolescent obesity, remains relatively underexamined. This review surveys numerous classes of chemicals for which this hypothesis has been explored. We focus on human data where they exist and also discuss the findings of rodent and cell culture studies. Organochlorine chemicals as well as several

show abstract

Section: Unique Susceptibility Of Obese Children and Adolescentsmentioning

confidence: 99%

Childhood Obesity and Environmental Chemicals

Merrill

Birnbaum

2011

Mount Sinai J Medicine

152

113

View full text Add to dashboard Cite

show abstract

“…Lymphoid organs and cells of the immune system are strategically located to monitor physiological portals of entry and may be among the first cells to participate in the absorption, distribution and biotransformation of xenobiotic compounds entering an animal. In mammals, ingested fat-soluble chemicals are taken up into the lacteal absorption from the gut and transit the mesenteric lymphatic drainage to the vascular circulation via the thoracic duct, bypassing the liver (Yoo et al, 1984;Busbee et ai, 1985;Wilson el al., 1985). Therefore, fat soluble chemicals in the diet incorporated into chylomicrons are peripherally distributed prior to encountering hepatic detoxification mechanisms, with potential exposure of essentially all peripheral organs and cells to unmetabolised fat-soluble hydrocarbons.…”

Section: Discussionmentioning

confidence: 99%

Environmental pollutants and marine mammal health: The potential impact of hydrocarbons and halogenated hydrocarbons on immune system dysfunction

Busbee¹,

Tizard²,

Sroit³

et al. 2020

JCRM

View full text Add to dashboard Cite

This paper provides a detailed review of the immunotoxicological effects of environmental pollutants on the health of marine mammals, particularly in relation to their impact on the immune system and mechanisms of toxicity. Environmental pollutants are increasingly implicated (both directly and indirectly) with the onset of infectious disease and related mortality incidents in marine mammals,. The release of chemicals into the marine environment and the subsequent bioaccumulation up the food chain may pose a serious threat to marine mammals inhabiting contaminated areas; this has been documented in various studies of pollutant concentrations in tissue samples and large scale mass mortalities. Data correlating pollutant residues with altered reproductive/developmental states, and immune system dysfunction in particular, are reported for terrestrial mammals and suggest a similar association in marine mammals. Immunology is emphasised as a tool for assessing marine mammal health using quantitative and qualitative techniques to establish the effects of chemical pollutants. This has become increasingly important in relation to the subsequent dangers that may be posed to humans through any indirect exposure via the food chain.

show abstract

“…In vitro data indicate that triglyceride concentrations are more directly correlated with B[a]P uptake than are concentrations of other lipoproteins, and suggest that a small change in serum triglyceride concentration could cause a significant change in the uptake of B[a]P, thereby influencing the level of circulating carcinogen [Yoo et al, 1984]. In this study, simple regression analysis showed a significant inverse relationship between triglyceride concentrations and DNA-adduct levels in the aorta of the ApoE*3-Leiden mice.…”

Section: Discussionmentioning

confidence: 99%

Modulation of plasma lipid levels affects benzo[a]pyrene‐induced DNA damage in tissues of two hyperlipidemic mouse models

Curfs

Beckers

Godschalk

et al. 2003

Environ and Mol Mutagen

View full text Add to dashboard Cite

The role of plasma lipids in the uptake, transportation, and distribution of lipophilic carcinogens like benzo[a]pyrene (B[a]P) remains unclear. Therefore, we studied the effects of dietary-modulated plasma lipids on B[a]P-induced DNA damage in several organs of two hyperlipidemic mouse models. Male apolipoprotein E (ApoE)*3-Leiden (n = 22) and ApoE knockout (ApoE-KO) mice (n = 20) were fed a high-fat cholesterol (HFC) diet or low-fat cholesterol (LFC; standard mouse chow) diet for 3 weeks, after which the animals were exposed to a single oral dose of 5 mg/kg bw B[a]P or vehicle and killed 4 days later. Plasma lipids were determined and DNA adducts were measured in aorta, heart, lung, liver, brain, and stomach. Total cholesterol and low-density lipoprotein (LDL) cholesterol were increased in all animals on a HFC diet, whereas a decrease of triglycerides was seen only in the ApoE-KO mice. In ApoE-KO mice on a normal diet, DNA-adduct levels were highest in aorta (10.8 +/- 1.4 adducts/10(8) nucleotides), followed by brain (7.8 +/- 1.3), lung (3.3 +/- 0.7), heart (3.1 +/- 0.6), liver (1.5 +/- 0.2) and stomach (1.2 +/- 0.2). In the ApoE*3-Leiden mice, adduct levels were equally high in aorta, heart, and lung (4.6 +/- 0.7, 5.0 +/- 0.5 and 4.6 +/- 0.4, respectively), followed by stomach (2.7 +/- 0.4), brain (2.3 +/- 0.2), and liver (1.7 +/- 0.2). In the ApoE-KO mice, the HFC diet intervention resulted in lower adduct levels in lung (2.1 +/- 0.2), heart (1.9 +/- 0.2), and brain (2.9 +/- 0.5), as compared with the LFC group. In contrast, a nonsignificant increase of adducts was found in aorta (13.1 +/- 1.5). A similar but nonsignificant trend was observed in the ApoE*3-Leiden mice. Multiple regression analysis showed that in aorta, DNA adducts were inversely related to plasma triglycerides (P = 0.004) and were also modulated by the ApoE genotype (P < 0.001). The results of the present study support further investigation into the role of dietary modulation of plasma lipids, ApoE, and polycyclic aromatic hydrocarbon exposure on the formation of DNA adducts in chronic degenerative diseases.

show abstract

Benzo[a]pyrene Uptake by Serum Lipids: Correlation with Triglyceride Concentration

Cited by 8 publications

References 9 publications

Childhood Obesity and Environmental Chemicals

Childhood Obesity and Environmental Chemicals

Environmental pollutants and marine mammal health: The potential impact of hydrocarbons and halogenated hydrocarbons on immune system dysfunction

Modulation of plasma lipid levels affects benzo[a]pyrene‐induced DNA damage in tissues of two hyperlipidemic mouse models

Contact Info

Product

Resources

About